View in EDS

Development of a fibrous poly (xylitol sebacate) sheet for endothelial basement membrane tissue engineering.

Saved in:
Bibliographic Details
Title: Development of a fibrous poly (xylitol sebacate) sheet for endothelial basement membrane tissue engineering.
Authors: Lavarian, Hanieh1 (AUTHOR), Sigaroodi, Faraz2 (AUTHOR), Ganjoury, Camellia3 (AUTHOR), Salamati, Setayesh4 (AUTHOR), Vahidi, Bahman1 (AUTHOR), Najmoddin, Najmeh4 (AUTHOR), Baharifar, Hadi5 (AUTHOR), Khani, Mohammad-Mehdi2 (AUTHOR) khani@sbmu.ac.ir
Source: Journal of Biomaterials Science -- Polymer Edition. Jun2026, Vol. 37 Issue 9, p1619-1637. 19p.
Subjects: Tissue engineering, Basal lamina, Electrospinning, Cell culture, Arterial grafts, Biocompatibility, Polymers, Mesenchymal stem cells
Abstract: An essential part of designing cardiovascular grafts is the fabrication of an artificial endothelial basement membrane (EBM) with the ability to support endothelial differentiation, especially under physiological dynamic forces. In this study, we introduce a novel artificial EBM constructed from a poly (xylitol sebacate) (PXS) polymer. First, the PXS prepolymer (pPXS) was blended with polyvinyl alcohol (PVA) at different ratios to achieve optimized production with a minimum amount of PVA to fabricate well-organized electrospun fiber networks of pPXS/PVA. Subsequently, pPXS/PVA was cross-linked at 120 °C under vacuum for two days to form a cPXS/PVA meshwork. Then, PVA and remaining pPXS were removed from the cPXS/PVA meshworks by serial rinsing in deionized water and ethanol to fabricate a defect-free fibrous sheet of cPXS. The fibrous cPXS sheets were characterized in terms of their structural, mechanical, and biological performance. The results confirmed that the cPXS sheets exhibited appropriate mechanical strength, acceptable wettability, ideal porosity, degradation behavior, and superior biocompatibility. Moreover, cPXS, as an artificial EBM, is capable of supporting endothelial differentiation of mesenchymal stem cells under dynamic culture conditions in a parallel plate bioreactor. Therefore, it can be inferred that fibrous cPXS sheet can be an ideal candidate for EBM tissue engineering and development of functional cardiovascular grafts. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Biomaterials Science -- Polymer Edition is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
FullText Text:
  Availability: 0
Header DbId: egs
DbLabel: Engineering Source
An: 194575065
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Development of a fibrous poly (xylitol sebacate) sheet for endothelial basement membrane tissue engineering.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Lavarian%2C+Hanieh%22">Lavarian, Hanieh</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sigaroodi%2C+Faraz%22">Sigaroodi, Faraz</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ganjoury%2C+Camellia%22">Ganjoury, Camellia</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Salamati%2C+Setayesh%22">Salamati, Setayesh</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vahidi%2C+Bahman%22">Vahidi, Bahman</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Najmoddin%2C+Najmeh%22">Najmoddin, Najmeh</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Baharifar%2C+Hadi%22">Baharifar, Hadi</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Khani%2C+Mohammad-Mehdi%22">Khani, Mohammad-Mehdi</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> khani@sbmu.ac.ir</i>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Journal+of+Biomaterials+Science+--+Polymer+Edition%22">Journal of Biomaterials Science -- Polymer Edition</searchLink>. Jun2026, Vol. 37 Issue 9, p1619-1637. 19p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Tissue+engineering%22">Tissue engineering</searchLink><br /><searchLink fieldCode="DE" term="%22Basal+lamina%22">Basal lamina</searchLink><br /><searchLink fieldCode="DE" term="%22Electrospinning%22">Electrospinning</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+culture%22">Cell culture</searchLink><br /><searchLink fieldCode="DE" term="%22Arterial+grafts%22">Arterial grafts</searchLink><br /><searchLink fieldCode="DE" term="%22Biocompatibility%22">Biocompatibility</searchLink><br /><searchLink fieldCode="DE" term="%22Polymers%22">Polymers</searchLink><br /><searchLink fieldCode="DE" term="%22Mesenchymal+stem+cells%22">Mesenchymal stem cells</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: An essential part of designing cardiovascular grafts is the fabrication of an artificial endothelial basement membrane (EBM) with the ability to support endothelial differentiation, especially under physiological dynamic forces. In this study, we introduce a novel artificial EBM constructed from a poly (xylitol sebacate) (PXS) polymer. First, the PXS prepolymer (pPXS) was blended with polyvinyl alcohol (PVA) at different ratios to achieve optimized production with a minimum amount of PVA to fabricate well-organized electrospun fiber networks of pPXS/PVA. Subsequently, pPXS/PVA was cross-linked at 120 °C under vacuum for two days to form a cPXS/PVA meshwork. Then, PVA and remaining pPXS were removed from the cPXS/PVA meshworks by serial rinsing in deionized water and ethanol to fabricate a defect-free fibrous sheet of cPXS. The fibrous cPXS sheets were characterized in terms of their structural, mechanical, and biological performance. The results confirmed that the cPXS sheets exhibited appropriate mechanical strength, acceptable wettability, ideal porosity, degradation behavior, and superior biocompatibility. Moreover, cPXS, as an artificial EBM, is capable of supporting endothelial differentiation of mesenchymal stem cells under dynamic culture conditions in a parallel plate bioreactor. Therefore, it can be inferred that fibrous cPXS sheet can be an ideal candidate for EBM tissue engineering and development of functional cardiovascular grafts. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Biomaterials Science -- Polymer Edition is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=194575065
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/09205063.2025.2561316
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 19
        StartPage: 1619
    Subjects:
      – SubjectFull: Tissue engineering
        Type: general
      – SubjectFull: Basal lamina
        Type: general
      – SubjectFull: Electrospinning
        Type: general
      – SubjectFull: Cell culture
        Type: general
      – SubjectFull: Arterial grafts
        Type: general
      – SubjectFull: Biocompatibility
        Type: general
      – SubjectFull: Polymers
        Type: general
      – SubjectFull: Mesenchymal stem cells
        Type: general
    Titles:
      – TitleFull: Development of a fibrous poly (xylitol sebacate) sheet for endothelial basement membrane tissue engineering.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Lavarian, Hanieh
      – PersonEntity:
          Name:
            NameFull: Sigaroodi, Faraz
      – PersonEntity:
          Name:
            NameFull: Ganjoury, Camellia
      – PersonEntity:
          Name:
            NameFull: Salamati, Setayesh
      – PersonEntity:
          Name:
            NameFull: Vahidi, Bahman
      – PersonEntity:
          Name:
            NameFull: Najmoddin, Najmeh
      – PersonEntity:
          Name:
            NameFull: Baharifar, Hadi
      – PersonEntity:
          Name:
            NameFull: Khani, Mohammad-Mehdi
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 15
              M: 06
              Text: Jun2026
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-print
              Value: 09205063
          Numbering:
            – Type: volume
              Value: 37
            – Type: issue
              Value: 9
          Titles:
            – TitleFull: Journal of Biomaterials Science -- Polymer Edition
              Type: main
ResultId 1