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Study of Structure, Physico-Mechanical Properties and Biocompatibility of Modified Cellulose-Based Conduits to Replace Injured Blood Vessels.

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Title: Study of Structure, Physico-Mechanical Properties and Biocompatibility of Modified Cellulose-Based Conduits to Replace Injured Blood Vessels.
Authors: Parchaykina, Marina V.1 (AUTHOR) mary.isakina@yandex.ru, Baykov, Mikhail A.1,2 (AUTHOR), Revina, Elvira S.1 (AUTHOR), Vedunova, Maria V.2 (AUTHOR), Mishchenko, Tatiana A.2 (AUTHOR), Sausheva, Alena A.1 (AUTHOR), Ashurova, Parvina Z.1 (AUTHOR), Isaeva, Elizaveta I.1 (AUTHOR), Sinitsyn, Kirill D.1 (AUTHOR), Shchankin, Mikhail V.1 (AUTHOR), Nazarova, Natalia B.1 (AUTHOR), Bogatyreva, Alena O.1 (AUTHOR), Revin, Viktor V.1 (AUTHOR)
Source: Polymers (20734360). Jun2026, Vol. 18 Issue 11, p1389. 16p.
Subjects: Vascular grafts, Biocompatibility, Endothelial cells, Mechanical behavior of materials, Cellulose, Elasticity, Regenerative medicine, Nanofibers
Abstract: The article is devoted to the study of the structure, physico-mechanical properties and biocompatibility of modified conduits based on bacterial cellulose (BC) to replace injured blood vessels. It has been shown that both samples have almost the same elastic recoil and are superior to synthetic vascular grafts in terms of the parameters studied. It should be noted that the first modified sample is characterized by greater elasticity and lower tensile strength compared to the second sample; however, the physico-mechanical properties of the obtained conduits are in the range corresponding to native blood vessels. Scanning electron microscopy (SEM) demonstrated that the conduits under study had a fibrillar structure with nanosized pores that enabled the adhesion of endothelial cells on the internal surface of the vascular implant, improved elasticity under transverse pressure, and raised the elasticity modulus when stretching along the fibrils. Thermogravimetry revealed that elastic recoil formation depended on the nature of polyvinyl alcohol (PVA) interaction with the nanofibrillar structure of BC rather than on the content of polyvinyl alcohol used for modification. The MTT test results confirmed no cytotoxicity and high oxygen permeability in the studied samples, opening great opportunities for their application in regenerative biomedicine to replace injured blood vessels. [ABSTRACT FROM AUTHOR]
Copyright of Polymers (20734360) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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DbLabel: Engineering Source
An: 194587653
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Study of Structure, Physico-Mechanical Properties and Biocompatibility of Modified Cellulose-Based Conduits to Replace Injured Blood Vessels.
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  Data: <searchLink fieldCode="AR" term="%22Parchaykina%2C+Marina+V%2E%22">Parchaykina, Marina V.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> mary.isakina@yandex.ru</i><br /><searchLink fieldCode="AR" term="%22Baykov%2C+Mikhail+A%2E%22">Baykov, Mikhail A.</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Revina%2C+Elvira+S%2E%22">Revina, Elvira S.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vedunova%2C+Maria+V%2E%22">Vedunova, Maria V.</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mishchenko%2C+Tatiana+A%2E%22">Mishchenko, Tatiana A.</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sausheva%2C+Alena+A%2E%22">Sausheva, Alena A.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ashurova%2C+Parvina+Z%2E%22">Ashurova, Parvina Z.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Isaeva%2C+Elizaveta+I%2E%22">Isaeva, Elizaveta I.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sinitsyn%2C+Kirill+D%2E%22">Sinitsyn, Kirill D.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shchankin%2C+Mikhail+V%2E%22">Shchankin, Mikhail V.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nazarova%2C+Natalia+B%2E%22">Nazarova, Natalia B.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bogatyreva%2C+Alena+O%2E%22">Bogatyreva, Alena O.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Revin%2C+Viktor+V%2E%22">Revin, Viktor V.</searchLink><relatesTo>1</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Polymers+%2820734360%29%22">Polymers (20734360)</searchLink>. Jun2026, Vol. 18 Issue 11, p1389. 16p.
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  Data: <searchLink fieldCode="DE" term="%22Vascular+grafts%22">Vascular grafts</searchLink><br /><searchLink fieldCode="DE" term="%22Biocompatibility%22">Biocompatibility</searchLink><br /><searchLink fieldCode="DE" term="%22Endothelial+cells%22">Endothelial cells</searchLink><br /><searchLink fieldCode="DE" term="%22Mechanical+behavior+of+materials%22">Mechanical behavior of materials</searchLink><br /><searchLink fieldCode="DE" term="%22Cellulose%22">Cellulose</searchLink><br /><searchLink fieldCode="DE" term="%22Elasticity%22">Elasticity</searchLink><br /><searchLink fieldCode="DE" term="%22Regenerative+medicine%22">Regenerative medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Nanofibers%22">Nanofibers</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The article is devoted to the study of the structure, physico-mechanical properties and biocompatibility of modified conduits based on bacterial cellulose (BC) to replace injured blood vessels. It has been shown that both samples have almost the same elastic recoil and are superior to synthetic vascular grafts in terms of the parameters studied. It should be noted that the first modified sample is characterized by greater elasticity and lower tensile strength compared to the second sample; however, the physico-mechanical properties of the obtained conduits are in the range corresponding to native blood vessels. Scanning electron microscopy (SEM) demonstrated that the conduits under study had a fibrillar structure with nanosized pores that enabled the adhesion of endothelial cells on the internal surface of the vascular implant, improved elasticity under transverse pressure, and raised the elasticity modulus when stretching along the fibrils. Thermogravimetry revealed that elastic recoil formation depended on the nature of polyvinyl alcohol (PVA) interaction with the nanofibrillar structure of BC rather than on the content of polyvinyl alcohol used for modification. The MTT test results confirmed no cytotoxicity and high oxygen permeability in the studied samples, opening great opportunities for their application in regenerative biomedicine to replace injured blood vessels. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of Polymers (20734360) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.3390/polym18111389
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      – Code: eng
        Text: English
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        PageCount: 16
        StartPage: 1389
    Subjects:
      – SubjectFull: Vascular grafts
        Type: general
      – SubjectFull: Biocompatibility
        Type: general
      – SubjectFull: Endothelial cells
        Type: general
      – SubjectFull: Mechanical behavior of materials
        Type: general
      – SubjectFull: Cellulose
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      – SubjectFull: Elasticity
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      – SubjectFull: Regenerative medicine
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              Text: Jun2026
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