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Cu-MOFs Nanozymes with Ascorbate Oxidase and Peroxidase-like Activity for Sensitive Fluorometric Detection of Total Antioxidant Capacity in Fruits.

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Title: Cu-MOFs Nanozymes with Ascorbate Oxidase and Peroxidase-like Activity for Sensitive Fluorometric Detection of Total Antioxidant Capacity in Fruits.
Authors: Huang, Yanyan1,2 (AUTHOR), Chen, Jing1,2 (AUTHOR), Nasi, Ai3 (AUTHOR), Zhao, Yiming1,2 (AUTHOR), Ding, Xin2 (AUTHOR), Xu, Dan2,3 (AUTHOR), Lyu, Fengzhi2 (AUTHOR), Xu, Donghui1,2 (AUTHOR), Zhang, Meng2 (AUTHOR), Chen, Ge2 (AUTHOR), Liu, Guangyang1,2 (AUTHOR)
Source: Nanomaterials (2079-4991). Jun2026, Vol. 16 Issue 11, p665. 12p.
Subjects: Nanozymes, Metal-organic frameworks, Ascorbate oxidase, Oxidant status, Peroxidase, Fruit, Fluorimetry
Abstract: In this work, two-dimensional copper-based metal–organic frameworks (Cu-MOFs) nanozymes, including cuprous oxide-tetrakis (4-carboxyphenyl) porphyrin (Cu2O-TCPP) and copper-cuprous oxide-tetrakis (4-carboxyphenyl) porphyrin (Cu-Cu2O-TCPP), were synthesized, which exhibit dual ascorbate oxidase (AO) and peroxidase (POD)-like activities. The reductants, such as ascorbic acid (AA), can be oxidized by the cascade AO and POD catalysis on Cu-MOFs to oxidize p-phthalic acid (PTA) and generate fluorescence. Consequently, a fluorescence sensing platform for AA and other reducing substances was established. This platform offers potential for efficient and selective monitoring of reductive species and related antioxidant levels in food systems. The results showed that the two Cu-MOFs displayed favorable linear relationships (R2 ≥ 0.99) for the detection of AA, glutathione (GSH) and L-cysteine (L-Cys). Their limits of detection (LOD) were 5.3 μM for Cu2O-TCPP and 92.5 μM for Cu-Cu2O-TCPP. Finally, by detecting real samples of vitamin C tablets and fruits, the accuracy of the two Cu-MOFs nanos enzymes was validated, with Cu2O-TCPP showing higher accuracy. [ABSTRACT FROM AUTHOR]
Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Cu-MOFs Nanozymes with Ascorbate Oxidase and Peroxidase-like Activity for Sensitive Fluorometric Detection of Total Antioxidant Capacity in Fruits.
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  Data: <searchLink fieldCode="AR" term="%22Huang%2C+Yanyan%22">Huang, Yanyan</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Jing%22">Chen, Jing</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nasi%2C+Ai%22">Nasi, Ai</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhao%2C+Yiming%22">Zhao, Yiming</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ding%2C+Xin%22">Ding, Xin</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xu%2C+Dan%22">Xu, Dan</searchLink><relatesTo>2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lyu%2C+Fengzhi%22">Lyu, Fengzhi</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xu%2C+Donghui%22">Xu, Donghui</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Meng%22">Zhang, Meng</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Ge%22">Chen, Ge</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Guangyang%22">Liu, Guangyang</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Nanomaterials+%282079-4991%29%22">Nanomaterials (2079-4991)</searchLink>. Jun2026, Vol. 16 Issue 11, p665. 12p.
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  Data: <searchLink fieldCode="DE" term="%22Nanozymes%22">Nanozymes</searchLink><br /><searchLink fieldCode="DE" term="%22Metal-organic+frameworks%22">Metal-organic frameworks</searchLink><br /><searchLink fieldCode="DE" term="%22Ascorbate+oxidase%22">Ascorbate oxidase</searchLink><br /><searchLink fieldCode="DE" term="%22Oxidant+status%22">Oxidant status</searchLink><br /><searchLink fieldCode="DE" term="%22Peroxidase%22">Peroxidase</searchLink><br /><searchLink fieldCode="DE" term="%22Fruit%22">Fruit</searchLink><br /><searchLink fieldCode="DE" term="%22Fluorimetry%22">Fluorimetry</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: In this work, two-dimensional copper-based metal–organic frameworks (Cu-MOFs) nanozymes, including cuprous oxide-tetrakis (4-carboxyphenyl) porphyrin (Cu2O-TCPP) and copper-cuprous oxide-tetrakis (4-carboxyphenyl) porphyrin (Cu-Cu2O-TCPP), were synthesized, which exhibit dual ascorbate oxidase (AO) and peroxidase (POD)-like activities. The reductants, such as ascorbic acid (AA), can be oxidized by the cascade AO and POD catalysis on Cu-MOFs to oxidize p-phthalic acid (PTA) and generate fluorescence. Consequently, a fluorescence sensing platform for AA and other reducing substances was established. This platform offers potential for efficient and selective monitoring of reductive species and related antioxidant levels in food systems. The results showed that the two Cu-MOFs displayed favorable linear relationships (R2 ≥ 0.99) for the detection of AA, glutathione (GSH) and L-cysteine (L-Cys). Their limits of detection (LOD) were 5.3 μM for Cu2O-TCPP and 92.5 μM for Cu-Cu2O-TCPP. Finally, by detecting real samples of vitamin C tablets and fruits, the accuracy of the two Cu-MOFs nanos enzymes was validated, with Cu2O-TCPP showing higher accuracy. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.3390/nano16110665
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        Text: English
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        PageCount: 12
        StartPage: 665
    Subjects:
      – SubjectFull: Nanozymes
        Type: general
      – SubjectFull: Metal-organic frameworks
        Type: general
      – SubjectFull: Ascorbate oxidase
        Type: general
      – SubjectFull: Oxidant status
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      – SubjectFull: Peroxidase
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      – SubjectFull: Fruit
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      – SubjectFull: Fluorimetry
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      – TitleFull: Cu-MOFs Nanozymes with Ascorbate Oxidase and Peroxidase-like Activity for Sensitive Fluorometric Detection of Total Antioxidant Capacity in Fruits.
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              Text: Jun2026
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