View in EDS HTML Full Text PDF Full Text

Mapping Therapeutic Regulatory T Cell Fate with MRI: Current Strategies and Translational Outlook.

Saved in:
Bibliographic Details
Title: Mapping Therapeutic Regulatory T Cell Fate with MRI: Current Strategies and Translational Outlook.
Authors: Ping, Yu1 (AUTHOR), Chen, Lydia1,2 (AUTHOR), Hoenig, Jacob Joel1 (AUTHOR), Yang, Xiaohan1,2 (AUTHOR), Chapelin, Fanny1,2 (AUTHOR) fachapelin@ucsd.edu
Source: Nanomaterials (2079-4991). Jun2026, Vol. 16 Issue 11, p691. 24p.
Subjects: Regulatory T cells, Intracellular tracking, Graft versus host disease, Immunologic diseases, Graft rejection, Autoimmune diseases
Abstract: Adoptive cell therapies, and more specifically, regulatory T cell (Treg) therapies, have shown significant therapeutic promise across multiple immune-mediated diseases including graft-versus-host disease (GvHD), solid organ transplant (SOT) rejection, and autoimmune diseases. One key challenge is the lack of insight into the biodistribution and fate of adoptively transferred T cells and Tregs in living organisms. These uncertainties delay progress on establishing optimal dosage(s), infusion timing and route, as well as investigations into off-target effects. Magnetic resonance imaging (MRI) cell tracking is particularly beneficial in this setting because it enables real-time, deep-tissue coverage without ionizing radiation. In this review, we compare existing MRI T cell tracking strategies using iron oxide particles and fluorinated agents. We describe preclinical and clinical applications of MRI for cell therapy tracking and provide a perspective on the potential impact on the field. [ABSTRACT FROM AUTHOR]
Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: egs
DbLabel: Engineering Source
An: 194587865
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Mapping Therapeutic Regulatory T Cell Fate with MRI: Current Strategies and Translational Outlook.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Ping%2C+Yu%22">Ping, Yu</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Lydia%22">Chen, Lydia</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hoenig%2C+Jacob+Joel%22">Hoenig, Jacob Joel</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yang%2C+Xiaohan%22">Yang, Xiaohan</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chapelin%2C+Fanny%22">Chapelin, Fanny</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> fachapelin@ucsd.edu</i>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Nanomaterials+%282079-4991%29%22">Nanomaterials (2079-4991)</searchLink>. Jun2026, Vol. 16 Issue 11, p691. 24p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Regulatory+T+cells%22">Regulatory T cells</searchLink><br /><searchLink fieldCode="DE" term="%22Intracellular+tracking%22">Intracellular tracking</searchLink><br /><searchLink fieldCode="DE" term="%22Graft+versus+host+disease%22">Graft versus host disease</searchLink><br /><searchLink fieldCode="DE" term="%22Immunologic+diseases%22">Immunologic diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Graft+rejection%22">Graft rejection</searchLink><br /><searchLink fieldCode="DE" term="%22Autoimmune+diseases%22">Autoimmune diseases</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Adoptive cell therapies, and more specifically, regulatory T cell (Treg) therapies, have shown significant therapeutic promise across multiple immune-mediated diseases including graft-versus-host disease (GvHD), solid organ transplant (SOT) rejection, and autoimmune diseases. One key challenge is the lack of insight into the biodistribution and fate of adoptively transferred T cells and Tregs in living organisms. These uncertainties delay progress on establishing optimal dosage(s), infusion timing and route, as well as investigations into off-target effects. Magnetic resonance imaging (MRI) cell tracking is particularly beneficial in this setting because it enables real-time, deep-tissue coverage without ionizing radiation. In this review, we compare existing MRI T cell tracking strategies using iron oxide particles and fluorinated agents. We describe preclinical and clinical applications of MRI for cell therapy tracking and provide a perspective on the potential impact on the field. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=194587865
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.3390/nano16110691
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 24
        StartPage: 691
    Subjects:
      – SubjectFull: Regulatory T cells
        Type: general
      – SubjectFull: Intracellular tracking
        Type: general
      – SubjectFull: Graft versus host disease
        Type: general
      – SubjectFull: Immunologic diseases
        Type: general
      – SubjectFull: Graft rejection
        Type: general
      – SubjectFull: Autoimmune diseases
        Type: general
    Titles:
      – TitleFull: Mapping Therapeutic Regulatory T Cell Fate with MRI: Current Strategies and Translational Outlook.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Ping, Yu
      – PersonEntity:
          Name:
            NameFull: Chen, Lydia
      – PersonEntity:
          Name:
            NameFull: Hoenig, Jacob Joel
      – PersonEntity:
          Name:
            NameFull: Yang, Xiaohan
      – PersonEntity:
          Name:
            NameFull: Chapelin, Fanny
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 06
              Text: Jun2026
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-print
              Value: 20794991
          Numbering:
            – Type: volume
              Value: 16
            – Type: issue
              Value: 11
          Titles:
            – TitleFull: Nanomaterials (2079-4991)
              Type: main
ResultId 1