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Valorization of Purple Prickly Pear Peel By‐Products: Antiproliferative and Pro‐Apoptotic Effects on Human Colorectal Cancer Cells HCT116.

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Title: Valorization of Purple Prickly Pear Peel By‐Products: Antiproliferative and Pro‐Apoptotic Effects on Human Colorectal Cancer Cells HCT116.
Authors: Armas Diaz, Yasmany1,2,3,4 (AUTHOR), Qi, Zexiu1,2,3,4 (AUTHOR), Yang, Bei1,2,3,4 (AUTHOR), Cianciosi, Danila1,2,3,4 (AUTHOR), Mazzoni, Luca5 (AUTHOR), Gasparrini, Massimiliano5 (AUTHOR), Forbes Hernandez, Tamara Y.6 (AUTHOR), Quiles, José L.7 (AUTHOR), Calderón Iglesias, Rubén8,9,10 (AUTHOR), Battino, Maurizio1,2,3,4,8,11 (AUTHOR) m.a.battino@staff.univpm.it, Giampieri, Francesca1,2,3,4,8 (AUTHOR), Henheik, Prisca-Maryla (AUTHOR) phenheik@wiley.com
Source: Journal of Food Biochemistry. 6/18/2026, Vol. 2026, p1-17. 17p.
Subjects: Colorectal cancer, Inhibition of cellular proliferation, Apoptosis inhibition, Opuntia, Oxidant status, Cell cycle regulation, Applied sciences
Abstract: Opuntia ficus-indica peel is known to possess antioxidant, anti‐inflammatory, and anticancer activities and currently is discarded or used for animal feeding. Within this context, the aim of this work was to evaluate the antiproliferative and pro‐apoptotic effect of purple prickly pear peel extract (PPE) on the human colon adenocarcinoma cancer cell line (HTC116). The methanolic extract of PPE was characterized in terms of betalain and polyphenols as well as total antioxidant capacity. Cell viability, apoptosis induction, cell cycle arrest, and reactive oxygen species (ROS) production assays were performed. Important proteins and genes related to proliferation and apoptosis were determined. PPE represents a good source of bioactive compounds with a high antioxidant capacity. Cell viability was reduced gradually by PPE treatments, with lower effects in nontumorigenic cells. Compared to the control group, a significant induction of apoptosis as well as cell cycle arrest in the sub‐G1 phase and ROS production was observed in PPE‐treated cells. Furthermore, the treatment induced the overexpression of p53 at protein levels and upregulated the mRNA expression of pro‐apoptotic BAX, CASP9, BID, and CYCS, along with the significant decrease of anti‐apoptotic BCL2 gene expression. Simultaneously, cyclin D1 and CDK4 gene expression were significantly decreased, while p21 increased considerably. The treatment also induced the downregulation of Her2 and PI3K at protein levels and caused the suppression of PI3KCA and mTOR expression at gene levels. Overall, these findings suggested that PPE has potential anticancer effects against human colon adenocarcinoma progression. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Food Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Valorization of Purple Prickly Pear Peel By‐Products: Antiproliferative and Pro‐Apoptotic Effects on Human Colorectal Cancer Cells HCT116.
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  Data: <searchLink fieldCode="AR" term="%22Armas+Diaz%2C+Yasmany%22">Armas Diaz, Yasmany</searchLink><relatesTo>1,2,3,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Qi%2C+Zexiu%22">Qi, Zexiu</searchLink><relatesTo>1,2,3,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yang%2C+Bei%22">Yang, Bei</searchLink><relatesTo>1,2,3,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cianciosi%2C+Danila%22">Cianciosi, Danila</searchLink><relatesTo>1,2,3,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mazzoni%2C+Luca%22">Mazzoni, Luca</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gasparrini%2C+Massimiliano%22">Gasparrini, Massimiliano</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Forbes+Hernandez%2C+Tamara+Y%2E%22">Forbes Hernandez, Tamara Y.</searchLink><relatesTo>6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Quiles%2C+José+L%2E%22">Quiles, José L.</searchLink><relatesTo>7</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Calderón+Iglesias%2C+Rubén%22">Calderón Iglesias, Rubén</searchLink><relatesTo>8,9,10</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Battino%2C+Maurizio%22">Battino, Maurizio</searchLink><relatesTo>1,2,3,4,8,11</relatesTo> (AUTHOR)<i> m.a.battino@staff.univpm.it</i><br /><searchLink fieldCode="AR" term="%22Giampieri%2C+Francesca%22">Giampieri, Francesca</searchLink><relatesTo>1,2,3,4,8</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Henheik%2C+Prisca-Maryla%22">Henheik, Prisca-Maryla</searchLink> (AUTHOR)<i> phenheik@wiley.com</i>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Food+Biochemistry%22">Journal of Food Biochemistry</searchLink>. 6/18/2026, Vol. 2026, p1-17. 17p.
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  Data: <searchLink fieldCode="DE" term="%22Colorectal+cancer%22">Colorectal cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Inhibition+of+cellular+proliferation%22">Inhibition of cellular proliferation</searchLink><br /><searchLink fieldCode="DE" term="%22Apoptosis+inhibition%22">Apoptosis inhibition</searchLink><br /><searchLink fieldCode="DE" term="%22Opuntia%22">Opuntia</searchLink><br /><searchLink fieldCode="DE" term="%22Oxidant+status%22">Oxidant status</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+cycle+regulation%22">Cell cycle regulation</searchLink><br /><searchLink fieldCode="DE" term="%22Applied+sciences%22">Applied sciences</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Opuntia ficus-indica peel is known to possess antioxidant, anti‐inflammatory, and anticancer activities and currently is discarded or used for animal feeding. Within this context, the aim of this work was to evaluate the antiproliferative and pro‐apoptotic effect of purple prickly pear peel extract (PPE) on the human colon adenocarcinoma cancer cell line (HTC116). The methanolic extract of PPE was characterized in terms of betalain and polyphenols as well as total antioxidant capacity. Cell viability, apoptosis induction, cell cycle arrest, and reactive oxygen species (ROS) production assays were performed. Important proteins and genes related to proliferation and apoptosis were determined. PPE represents a good source of bioactive compounds with a high antioxidant capacity. Cell viability was reduced gradually by PPE treatments, with lower effects in nontumorigenic cells. Compared to the control group, a significant induction of apoptosis as well as cell cycle arrest in the sub‐G1 phase and ROS production was observed in PPE‐treated cells. Furthermore, the treatment induced the overexpression of p53 at protein levels and upregulated the mRNA expression of pro‐apoptotic BAX, CASP9, BID, and CYCS, along with the significant decrease of anti‐apoptotic BCL2 gene expression. Simultaneously, cyclin D1 and CDK4 gene expression were significantly decreased, while p21 increased considerably. The treatment also induced the downregulation of Her2 and PI3K at protein levels and caused the suppression of PI3KCA and mTOR expression at gene levels. Overall, these findings suggested that PPE has potential anticancer effects against human colon adenocarcinoma progression. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Journal of Food Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1155/jfbc/9961129
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      – Code: eng
        Text: English
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        PageCount: 17
        StartPage: 1
    Subjects:
      – SubjectFull: Colorectal cancer
        Type: general
      – SubjectFull: Inhibition of cellular proliferation
        Type: general
      – SubjectFull: Apoptosis inhibition
        Type: general
      – SubjectFull: Opuntia
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      – SubjectFull: Oxidant status
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      – SubjectFull: Cell cycle regulation
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      – SubjectFull: Applied sciences
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      – TitleFull: Valorization of Purple Prickly Pear Peel By‐Products: Antiproliferative and Pro‐Apoptotic Effects on Human Colorectal Cancer Cells HCT116.
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              Text: 6/18/2026
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              Y: 2026
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