A homogeneous fluorescence-electrochemiluminescence sensing platform based on EDTA-RuCOFs: ultrasensitive detection of Cu²⁺ via a chelation-quenching mechanism.
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| Title: | A homogeneous fluorescence-electrochemiluminescence sensing platform based on EDTA-RuCOFs: ultrasensitive detection of Cu²⁺ via a chelation-quenching mechanism. |
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| Authors: | Fan, Tao1 (AUTHOR), Yin, Zhaojiang2 (AUTHOR), Wu, Wenqi1 (AUTHOR), Wei, Guobing1 (AUTHOR), Zhang, Jing1 (AUTHOR), Fan, Hao1 (AUTHOR) fanhao11@aliyun.com, Bao, Mengjie1 (AUTHOR) 635544635@qq.com, Li, Huijie1 (AUTHOR) lihuijie0820@163.com |
| Source: | Microchimica Acta. Jun2026, Vol. 193 Issue 6, p1-12. 12p. |
| Subjects: | Copper analysis, Fluorescence, Electrochemiluminescence, Chemical detectors, Luminescence quenching, Environmental monitoring |
| Abstract: | The rational design and synthesis is reported of a novel ethylenediaminetetraacetic acid (EDTA) functionalized ruthenium-based covalent organic framework (EDTA-RuCOF) and its application in constructing a homogeneous dual-mode fluorescence/electrochemiluminescence (FL–ECL) sensing platform for ultrasensitive Cu²⁺ detection. The COF was built using tris(4,4′-dicarboxybipyridine)ruthenium chloride as the luminophore and 4,4′,4″-(1,3,5-triazine-2,4,6-triyl)trianiline as the structural node. EDTA moieties were subsequently anchored onto the framework through amide coupling, introducing N, N′-chelating sites within the COF framework. Unlike conventional heterogeneous sensors relying on electrode surface immobilization, the EDTA-RuCOFs are stably and homogeneously dispersed in solution, enabling truly homogeneous detection throughout the entire reaction volume. This strategy helps mitigate limitations commonly associated with interfacial sensors of interfacial sensors, significantly enhancing reaction efficiency while avoiding common drawbacks such as active-site burial, signal attenuation, and instability of modification layers. Upon selective coordination with Cu²⁺, the fluorescence and electrochemiluminescence signals of the surrounding Ru(bpy)₃²⁺ luminophores are synchronously quenched through efficient electron and energy transfer pathways, consistent with a coordination-induced "chelation-quenching" sensing process. The resulting homogeneous sensor exhibits excellent analytical performance, achieving ultralow detection limits of 2.16 pM and 263 fM for Cu²⁺ via FL and ECL modes, respectively, along with a wide linear range and high selectivity. Practical applicability was further demonstrated by accurate Cu²⁺ determination in complex real samples, including lake water, rat serum, and the traditional Chinese medicine Astragalus, with results in good agreement with those obtained by ICP-MS. Overall, this work provides a robust homogeneous dual-mode sensing strategy for trace heavy-metal detection and highlights the considerable potential of functionalized COF materials in advanced analytical and environmental monitoring applications. [ABSTRACT FROM AUTHOR] |
| Copyright of Microchimica Acta is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 194722248 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: A homogeneous fluorescence-electrochemiluminescence sensing platform based on EDTA-RuCOFs: ultrasensitive detection of Cu²⁺ via a chelation-quenching mechanism. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Fan%2C+Tao%22">Fan, Tao</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yin%2C+Zhaojiang%22">Yin, Zhaojiang</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wu%2C+Wenqi%22">Wu, Wenqi</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wei%2C+Guobing%22">Wei, Guobing</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Jing%22">Zhang, Jing</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fan%2C+Hao%22">Fan, Hao</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> fanhao11@aliyun.com</i><br /><searchLink fieldCode="AR" term="%22Bao%2C+Mengjie%22">Bao, Mengjie</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> 635544635@qq.com</i><br /><searchLink fieldCode="AR" term="%22Li%2C+Huijie%22">Li, Huijie</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> lihuijie0820@163.com</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Microchimica+Acta%22">Microchimica Acta</searchLink>. Jun2026, Vol. 193 Issue 6, p1-12. 12p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Copper+analysis%22">Copper analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Fluorescence%22">Fluorescence</searchLink><br /><searchLink fieldCode="DE" term="%22Electrochemiluminescence%22">Electrochemiluminescence</searchLink><br /><searchLink fieldCode="DE" term="%22Chemical+detectors%22">Chemical detectors</searchLink><br /><searchLink fieldCode="DE" term="%22Luminescence+quenching%22">Luminescence quenching</searchLink><br /><searchLink fieldCode="DE" term="%22Environmental+monitoring%22">Environmental monitoring</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The rational design and synthesis is reported of a novel ethylenediaminetetraacetic acid (EDTA) functionalized ruthenium-based covalent organic framework (EDTA-RuCOF) and its application in constructing a homogeneous dual-mode fluorescence/electrochemiluminescence (FL–ECL) sensing platform for ultrasensitive Cu²⁺ detection. The COF was built using tris(4,4′-dicarboxybipyridine)ruthenium chloride as the luminophore and 4,4′,4″-(1,3,5-triazine-2,4,6-triyl)trianiline as the structural node. EDTA moieties were subsequently anchored onto the framework through amide coupling, introducing N, N′-chelating sites within the COF framework. Unlike conventional heterogeneous sensors relying on electrode surface immobilization, the EDTA-RuCOFs are stably and homogeneously dispersed in solution, enabling truly homogeneous detection throughout the entire reaction volume. This strategy helps mitigate limitations commonly associated with interfacial sensors of interfacial sensors, significantly enhancing reaction efficiency while avoiding common drawbacks such as active-site burial, signal attenuation, and instability of modification layers. Upon selective coordination with Cu²⁺, the fluorescence and electrochemiluminescence signals of the surrounding Ru(bpy)₃²⁺ luminophores are synchronously quenched through efficient electron and energy transfer pathways, consistent with a coordination-induced "chelation-quenching" sensing process. The resulting homogeneous sensor exhibits excellent analytical performance, achieving ultralow detection limits of 2.16 pM and 263 fM for Cu²⁺ via FL and ECL modes, respectively, along with a wide linear range and high selectivity. Practical applicability was further demonstrated by accurate Cu²⁺ determination in complex real samples, including lake water, rat serum, and the traditional Chinese medicine Astragalus, with results in good agreement with those obtained by ICP-MS. Overall, this work provides a robust homogeneous dual-mode sensing strategy for trace heavy-metal detection and highlights the considerable potential of functionalized COF materials in advanced analytical and environmental monitoring applications. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Microchimica Acta is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00604-026-08082-8 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 12 StartPage: 1 Subjects: – SubjectFull: Copper analysis Type: general – SubjectFull: Fluorescence Type: general – SubjectFull: Electrochemiluminescence Type: general – SubjectFull: Chemical detectors Type: general – SubjectFull: Luminescence quenching Type: general – SubjectFull: Environmental monitoring Type: general Titles: – TitleFull: A homogeneous fluorescence-electrochemiluminescence sensing platform based on EDTA-RuCOFs: ultrasensitive detection of Cu²⁺ via a chelation-quenching mechanism. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Fan, Tao – PersonEntity: Name: NameFull: Yin, Zhaojiang – PersonEntity: Name: NameFull: Wu, Wenqi – PersonEntity: Name: NameFull: Wei, Guobing – PersonEntity: Name: NameFull: Zhang, Jing – PersonEntity: Name: NameFull: Fan, Hao – PersonEntity: Name: NameFull: Bao, Mengjie – PersonEntity: Name: NameFull: Li, Huijie IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: Jun2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 00263672 Numbering: – Type: volume Value: 193 – Type: issue Value: 6 Titles: – TitleFull: Microchimica Acta Type: main |
| ResultId | 1 |
