View in EDS HTML Full Text PDF Full Text

Crosslinker-Integrated Photocleavable Gelatin–PEG Hydrogel via Bioorthogonal SPAAC Chemistry for UV-Triggered On-Demand Degradation.

Saved in:
Bibliographic Details
Title: Crosslinker-Integrated Photocleavable Gelatin–PEG Hydrogel via Bioorthogonal SPAAC Chemistry for UV-Triggered On-Demand Degradation.
Authors: Kang, Yeon Tae1 (AUTHOR), Pyo, Gayeon1 (AUTHOR), Muthuramalingam, Karthika1 (AUTHOR), Lee, Hyun Jong1 (AUTHOR)
Source: Materials (1996-1944). Jun2026, Vol. 19 Issue 12, p2625. 15p.
Subjects: Hydrogels, Photodegradation, Click chemistry, Physical & theoretical chemistry, Drug delivery systems, Tissue scaffolds
Abstract: Light-triggered hydrogel systems offer precise spatiotemporal control over drug release, yet most existing approaches require direct chemical conjugation of a photocleavable linker to the payload, which risks compromising bioactivity and limits applicability to structurally diverse molecules. Here, we report a gelatin–poly(ethylene glycol) (PEG) hybrid hydrogel crosslinked via strain-promoted azide–alkyne cycloaddition (SPAAC) click chemistry, in which an o-nitrobenzyl photocleavable (PC) linker is incorporated into the PEG crosslinker arm rather than conjugated to the drug. Acetylated gelatin–azide (AGA) was synthesized by sequential azide functionalization and amine capping of gelatin, and four-arm PEG-PC-DBCO (4armPEG-PC-DBCO) was prepared by coupling a PC DBCO-PEG4-NHS ester to four-arm PEG amine. Successful incorporation of the azide, DBCO, and o-nitrobenzyl moieties was confirmed by FT-IR spectroscopy, 1H NMR spectroscopy, and UV-Vis spectrophotometry. Hydrogel formation under physiological conditions (PBS, 37 °C) without catalysts or initiators was verified by rheological frequency sweep analysis, which confirmed elastic-dominant behavior (G′ > G″). Upon irradiation at 365 nm, the crosslinker was cleaved, and rapid network dissolution was observed both macroscopically and by in situ time sweep rheology. This platform enables on-demand, UV-selective hydrogel degradation independently of payload identity, providing a versatile foundation for future controlled drug release applications and dynamic, on-demand degradable scaffolds for tissue engineering. [ABSTRACT FROM AUTHOR]
Copyright of Materials (1996-1944) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: egs
DbLabel: Engineering Source
An: 194907699
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Crosslinker-Integrated Photocleavable Gelatin–PEG Hydrogel via Bioorthogonal SPAAC Chemistry for UV-Triggered On-Demand Degradation.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Kang%2C+Yeon+Tae%22">Kang, Yeon Tae</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pyo%2C+Gayeon%22">Pyo, Gayeon</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Muthuramalingam%2C+Karthika%22">Muthuramalingam, Karthika</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lee%2C+Hyun+Jong%22">Lee, Hyun Jong</searchLink><relatesTo>1</relatesTo> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Materials+%281996-1944%29%22">Materials (1996-1944)</searchLink>. Jun2026, Vol. 19 Issue 12, p2625. 15p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Hydrogels%22">Hydrogels</searchLink><br /><searchLink fieldCode="DE" term="%22Photodegradation%22">Photodegradation</searchLink><br /><searchLink fieldCode="DE" term="%22Click+chemistry%22">Click chemistry</searchLink><br /><searchLink fieldCode="DE" term="%22Physical+%26+theoretical+chemistry%22">Physical & theoretical chemistry</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+delivery+systems%22">Drug delivery systems</searchLink><br /><searchLink fieldCode="DE" term="%22Tissue+scaffolds%22">Tissue scaffolds</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Light-triggered hydrogel systems offer precise spatiotemporal control over drug release, yet most existing approaches require direct chemical conjugation of a photocleavable linker to the payload, which risks compromising bioactivity and limits applicability to structurally diverse molecules. Here, we report a gelatin–poly(ethylene glycol) (PEG) hybrid hydrogel crosslinked via strain-promoted azide–alkyne cycloaddition (SPAAC) click chemistry, in which an o-nitrobenzyl photocleavable (PC) linker is incorporated into the PEG crosslinker arm rather than conjugated to the drug. Acetylated gelatin–azide (AGA) was synthesized by sequential azide functionalization and amine capping of gelatin, and four-arm PEG-PC-DBCO (4armPEG-PC-DBCO) was prepared by coupling a PC DBCO-PEG4-NHS ester to four-arm PEG amine. Successful incorporation of the azide, DBCO, and o-nitrobenzyl moieties was confirmed by FT-IR spectroscopy, 1H NMR spectroscopy, and UV-Vis spectrophotometry. Hydrogel formation under physiological conditions (PBS, 37 °C) without catalysts or initiators was verified by rheological frequency sweep analysis, which confirmed elastic-dominant behavior (G′ > G″). Upon irradiation at 365 nm, the crosslinker was cleaved, and rapid network dissolution was observed both macroscopically and by in situ time sweep rheology. This platform enables on-demand, UV-selective hydrogel degradation independently of payload identity, providing a versatile foundation for future controlled drug release applications and dynamic, on-demand degradable scaffolds for tissue engineering. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Materials (1996-1944) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=194907699
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.3390/ma19122625
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 15
        StartPage: 2625
    Subjects:
      – SubjectFull: Hydrogels
        Type: general
      – SubjectFull: Photodegradation
        Type: general
      – SubjectFull: Click chemistry
        Type: general
      – SubjectFull: Physical & theoretical chemistry
        Type: general
      – SubjectFull: Drug delivery systems
        Type: general
      – SubjectFull: Tissue scaffolds
        Type: general
    Titles:
      – TitleFull: Crosslinker-Integrated Photocleavable Gelatin–PEG Hydrogel via Bioorthogonal SPAAC Chemistry for UV-Triggered On-Demand Degradation.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Kang, Yeon Tae
      – PersonEntity:
          Name:
            NameFull: Pyo, Gayeon
      – PersonEntity:
          Name:
            NameFull: Muthuramalingam, Karthika
      – PersonEntity:
          Name:
            NameFull: Lee, Hyun Jong
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 15
              M: 06
              Text: Jun2026
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-print
              Value: 19961944
          Numbering:
            – Type: volume
              Value: 19
            – Type: issue
              Value: 12
          Titles:
            – TitleFull: Materials (1996-1944)
              Type: main
ResultId 1