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Electrospinning of Polycaprolactone Membranes Using Green Solvents for Organ-on-a-Chip Applications.

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Title: Electrospinning of Polycaprolactone Membranes Using Green Solvents for Organ-on-a-Chip Applications.
Authors: Dragun, Donna Danijela1 (AUTHOR), Kuzman, Karla1,2 (AUTHOR), Blažek, Marta1 (AUTHOR), Popović, Petra1,2 (AUTHOR), Radovanović-Perić, Floren1 (AUTHOR), Meštrović, Iva Rezić2 (AUTHOR), Faraguna, Fabio1 (AUTHOR), Meštrović, Ernest1 (AUTHOR) ernest.mestrovic@fkit.unizg.hr
Source: Polymers (20734360). Jun2026, Vol. 18 Issue 12, p1547. 18p.
Subjects: Electrospinning, Polycaprolactone, Solvents, Experimental design, Polymeric membranes, Biomedical engineering, Sustainability, Microphysiological systems
Abstract: Electrospinning is a highly versatile technique for fabricating nanofibrous membranes with high surface-area-to-volume ratios and tunable porosity. Although polycaprolactone (PCL) is widely utilized in biomedical engineering due to its biocompatibility, its electrospinning traditionally relies on hazardous organic solvents like dichloromethane (DCM) and N,N-dimethylformamide (DMF). This paper details the development of a fully sustainable, green electrospinning process for PCL using a bio-derived binary mixture of acetic acid and formic acid. Processing parameters (applied voltage, tip-to-collector distance, and flow rate) were systematically optimized using a Design of Experiments (DoE) response surface methodology. Scanning electron microscopy (SEM) confirmed the successful fabrication of uniform, bead-free nanofibers with a mean diameter of 247 nm, representing a 37.3% reduction compared to conventional DCM:DMF-spun matrices. Fourier-transform infrared spectroscopy (FTIR) verified complete solvent evaporates. [ABSTRACT FROM AUTHOR]
Copyright of Polymers (20734360) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Electrospinning of Polycaprolactone Membranes Using Green Solvents for Organ-on-a-Chip Applications.
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  Data: <searchLink fieldCode="AR" term="%22Dragun%2C+Donna+Danijela%22">Dragun, Donna Danijela</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kuzman%2C+Karla%22">Kuzman, Karla</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Blažek%2C+Marta%22">Blažek, Marta</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Popović%2C+Petra%22">Popović, Petra</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Radovanović-Perić%2C+Floren%22">Radovanović-Perić, Floren</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Meštrović%2C+Iva+Rezić%22">Meštrović, Iva Rezić</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Faraguna%2C+Fabio%22">Faraguna, Fabio</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Meštrović%2C+Ernest%22">Meštrović, Ernest</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> ernest.mestrovic@fkit.unizg.hr</i>
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  Data: <searchLink fieldCode="JN" term="%22Polymers+%2820734360%29%22">Polymers (20734360)</searchLink>. Jun2026, Vol. 18 Issue 12, p1547. 18p.
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  Data: <searchLink fieldCode="DE" term="%22Electrospinning%22">Electrospinning</searchLink><br /><searchLink fieldCode="DE" term="%22Polycaprolactone%22">Polycaprolactone</searchLink><br /><searchLink fieldCode="DE" term="%22Solvents%22">Solvents</searchLink><br /><searchLink fieldCode="DE" term="%22Experimental+design%22">Experimental design</searchLink><br /><searchLink fieldCode="DE" term="%22Polymeric+membranes%22">Polymeric membranes</searchLink><br /><searchLink fieldCode="DE" term="%22Biomedical+engineering%22">Biomedical engineering</searchLink><br /><searchLink fieldCode="DE" term="%22Sustainability%22">Sustainability</searchLink><br /><searchLink fieldCode="DE" term="%22Microphysiological+systems%22">Microphysiological systems</searchLink>
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  Data: Electrospinning is a highly versatile technique for fabricating nanofibrous membranes with high surface-area-to-volume ratios and tunable porosity. Although polycaprolactone (PCL) is widely utilized in biomedical engineering due to its biocompatibility, its electrospinning traditionally relies on hazardous organic solvents like dichloromethane (DCM) and N,N-dimethylformamide (DMF). This paper details the development of a fully sustainable, green electrospinning process for PCL using a bio-derived binary mixture of acetic acid and formic acid. Processing parameters (applied voltage, tip-to-collector distance, and flow rate) were systematically optimized using a Design of Experiments (DoE) response surface methodology. Scanning electron microscopy (SEM) confirmed the successful fabrication of uniform, bead-free nanofibers with a mean diameter of 247 nm, representing a 37.3% reduction compared to conventional DCM:DMF-spun matrices. Fourier-transform infrared spectroscopy (FTIR) verified complete solvent evaporates. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of Polymers (20734360) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.3390/polym18121547
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        Text: English
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      – SubjectFull: Electrospinning
        Type: general
      – SubjectFull: Polycaprolactone
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      – SubjectFull: Solvents
        Type: general
      – SubjectFull: Experimental design
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      – SubjectFull: Polymeric membranes
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      – SubjectFull: Biomedical engineering
        Type: general
      – SubjectFull: Sustainability
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      – SubjectFull: Microphysiological systems
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              M: 06
              Text: Jun2026
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