Increased Brownian Motion of Water Molecules in Livers With Advanced Fibrosis: Preclinical and Clinical Observations With Magnetic Resonance Imaging (MRI).
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| Title: | Increased Brownian Motion of Water Molecules in Livers With Advanced Fibrosis: Preclinical and Clinical Observations With Magnetic Resonance Imaging (MRI). |
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| Authors: | Xu, Fan-Yi1 (AUTHOR), Hu, Gen-Wen2 (AUTHOR), Zheng, Cun-Jing3 (AUTHOR), Huang, Hua4 (AUTHOR), Luo, Jie-Qi4 (AUTHOR), Zheng, Guang-Ping4 (AUTHOR), Duan, Xiao-Hui3 (AUTHOR), Loffroy, Romaric5 (AUTHOR), Wáng, Yì Xiáng J.1 (AUTHOR) yixiang_wang@cuhk.edu.hk |
| Source: | Molecular Imaging. 06/29/2026, Vol. 25, p1-13. 13p. |
| Subjects: | Hepatic fibrosis, Diffusion coefficients, Bile ducts, Brownian motion, Molecules, Magnetic resonance imaging |
| Abstract: | Despite the increased water content in fibrotic livers, numerous studies reported a decrease in apparent diffusion coefficient (ADC) in liver fibrosis. We argue that the ADC decrease in fibrotic livers is due to the "T2 shine-through" of ADC, as the longer T2 in liver fibrosis leads to less signal decay between the low and high b -value images. The metric slow diffusion coefficient (SDC), predominantly measuring Brownian motion of water molecules, was proposed to mitigate the difficulties associated with this "T2 shine-through" of ADC. This study calculated ADC and SDC of 1 rat study with liver fibrosis induced by biliary duct ligation (BDL), and 3 sets of human liver fibrosis data. To tease out the menopausal effect on liver SDC, only the results of men's livers were analyzed for the human datasets. The rat study showed that liver ADC decreased stepwise (in weeks after BDL procedure) following fibrosis induction, and SDC increased stepwise. In human studies, all 3 datasets consistently showed that advanced fibrosis had a liver ADC lower than that of earlier stage fibrosis; advanced fibrosis had a liver SDC higher than that of earlier stage fibrosis. [ABSTRACT FROM AUTHOR] |
| Copyright of Molecular Imaging is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 194971856 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Increased Brownian Motion of Water Molecules in Livers With Advanced Fibrosis: Preclinical and Clinical Observations With Magnetic Resonance Imaging (MRI). – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Xu%2C+Fan-Yi%22">Xu, Fan-Yi</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hu%2C+Gen-Wen%22">Hu, Gen-Wen</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zheng%2C+Cun-Jing%22">Zheng, Cun-Jing</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Huang%2C+Hua%22">Huang, Hua</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Luo%2C+Jie-Qi%22">Luo, Jie-Qi</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zheng%2C+Guang-Ping%22">Zheng, Guang-Ping</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Duan%2C+Xiao-Hui%22">Duan, Xiao-Hui</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Loffroy%2C+Romaric%22">Loffroy, Romaric</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wáng%2C+Yì+Xiáng+J%2E%22">Wáng, Yì Xiáng J.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> yixiang_wang@cuhk.edu.hk</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Molecular+Imaging%22">Molecular Imaging</searchLink>. 06/29/2026, Vol. 25, p1-13. 13p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Hepatic+fibrosis%22">Hepatic fibrosis</searchLink><br /><searchLink fieldCode="DE" term="%22Diffusion+coefficients%22">Diffusion coefficients</searchLink><br /><searchLink fieldCode="DE" term="%22Bile+ducts%22">Bile ducts</searchLink><br /><searchLink fieldCode="DE" term="%22Brownian+motion%22">Brownian motion</searchLink><br /><searchLink fieldCode="DE" term="%22Molecules%22">Molecules</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Despite the increased water content in fibrotic livers, numerous studies reported a decrease in apparent diffusion coefficient (ADC) in liver fibrosis. We argue that the ADC decrease in fibrotic livers is due to the "T2 shine-through" of ADC, as the longer T2 in liver fibrosis leads to less signal decay between the low and high b -value images. The metric slow diffusion coefficient (SDC), predominantly measuring Brownian motion of water molecules, was proposed to mitigate the difficulties associated with this "T2 shine-through" of ADC. This study calculated ADC and SDC of 1 rat study with liver fibrosis induced by biliary duct ligation (BDL), and 3 sets of human liver fibrosis data. To tease out the menopausal effect on liver SDC, only the results of men's livers were analyzed for the human datasets. The rat study showed that liver ADC decreased stepwise (in weeks after BDL procedure) following fibrosis induction, and SDC increased stepwise. In human studies, all 3 datasets consistently showed that advanced fibrosis had a liver ADC lower than that of earlier stage fibrosis; advanced fibrosis had a liver SDC higher than that of earlier stage fibrosis. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Molecular Imaging is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1177/15353508261465601 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 13 StartPage: 1 Subjects: – SubjectFull: Hepatic fibrosis Type: general – SubjectFull: Diffusion coefficients Type: general – SubjectFull: Bile ducts Type: general – SubjectFull: Brownian motion Type: general – SubjectFull: Molecules Type: general – SubjectFull: Magnetic resonance imaging Type: general Titles: – TitleFull: Increased Brownian Motion of Water Molecules in Livers With Advanced Fibrosis: Preclinical and Clinical Observations With Magnetic Resonance Imaging (MRI). Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Xu, Fan-Yi – PersonEntity: Name: NameFull: Hu, Gen-Wen – PersonEntity: Name: NameFull: Zheng, Cun-Jing – PersonEntity: Name: NameFull: Huang, Hua – PersonEntity: Name: NameFull: Luo, Jie-Qi – PersonEntity: Name: NameFull: Zheng, Guang-Ping – PersonEntity: Name: NameFull: Duan, Xiao-Hui – PersonEntity: Name: NameFull: Loffroy, Romaric – PersonEntity: Name: NameFull: Wáng, Yì Xiáng J. IsPartOfRelationships: – BibEntity: Dates: – D: 29 M: 06 Text: 06/29/2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 15353508 Numbering: – Type: volume Value: 25 Titles: – TitleFull: Molecular Imaging Type: main |
| ResultId | 1 |
