TAF1 and GCN5‐mediated histone acetylation of regulatory cascade AHL14/17‐A/NINV7 promotes sucrose catabolism and sugar accumulation for cold tolerance in Citrus.
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| Title: | TAF1 and GCN5‐mediated histone acetylation of regulatory cascade AHL14/17‐A/NINV7 promotes sucrose catabolism and sugar accumulation for cold tolerance in Citrus. |
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| Authors: | Dahro, Bachar1,2 (AUTHOR), Khan, Madiha1 (AUTHOR), Chu, Lele1 (AUTHOR), Zhu, Jian1 (AUTHOR), Shang, Xiangming1 (AUTHOR), Zeng, Xi1 (AUTHOR), Wu, Xiaoyu1 (AUTHOR), Hu, Wenqiang1 (AUTHOR), Lai, Xuelei3,4 (AUTHOR), Li, Chunlong1,3 (AUTHOR), Liu, Ji‐Hong1,3 (AUTHOR) liujihong@mail.hzau.edu.cn |
| Source: | New Phytologist. Aug2026, Vol. 251 Issue 3, p1221-1241. 21p. |
| Subjects: | Histone acetylation, Invertase, Plant epigenetics, Thermal tolerance (Physiology), DNA-binding proteins, Glucose metabolism, Epigenetics |
| Abstract: | Summary: Sugar metabolism plays a vital role in plant cold tolerance. Histone acetyltransferases (HATs) act as key epigenetic regulators of stress‐responsive genes, yet the function and mechanism underlying HAT‐mediated histone acetylation (HA) in regulation of sugar metabolism under cold stress remain largely unclear.In this study, we demonstrate that PtrAHL14 and PtrAHL17, two cold‐induced AT‐hook motif‐containing nuclear‐localized proteins (AHLs) from Poncirus trifoliata, interact with TATA‐binding protein (TBP)‐Associated Factor 1 (PtrTAF1) and General Control Nonrepressed protein 5 (PtrGCN5), forming a functional quaternary complex at the nuclear matrix. The AHLs recruit PtrTAF1 and PtrGCN5 to the matrix‐associated region of PtrA/NINV7, an alkaline/neutral invertase gene, leading to acetylation of H3K9, H3K14, H3K27, and H4K8 under cold stress. Furthermore, both HATs were found to modulate cold tolerance by cooperatively regulating PtrA/NINV7‐mediated accumulation of reducing sugars.PtrAHL14 and PtrAHL17 directly interact with H3 and H4 and enhance HA, while PtrTAF1 and PtrGCN5 exhibit accumulative effects on triggering HA, thereby amplifying AHL‐mediated regulation of PtrA/NINV7.Taken together, our findings unveil a novel HATs‐AHLs‐A/NINV7 regulatory module that epigenetically controls sucrose catabolism in response to cold stress, providing valuable insights into understanding the molecular regulation of sugar accumulation for improved cold tolerance. [ABSTRACT FROM AUTHOR] |
| Copyright of New Phytologist is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 195038694 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: TAF1 and GCN5‐mediated histone acetylation of regulatory cascade AHL14/17‐A/NINV7 promotes sucrose catabolism and sugar accumulation for cold tolerance in Citrus. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Dahro%2C+Bachar%22">Dahro, Bachar</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Khan%2C+Madiha%22">Khan, Madiha</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chu%2C+Lele%22">Chu, Lele</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhu%2C+Jian%22">Zhu, Jian</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shang%2C+Xiangming%22">Shang, Xiangming</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zeng%2C+Xi%22">Zeng, Xi</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wu%2C+Xiaoyu%22">Wu, Xiaoyu</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hu%2C+Wenqiang%22">Hu, Wenqiang</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lai%2C+Xuelei%22">Lai, Xuelei</searchLink><relatesTo>3,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Chunlong%22">Li, Chunlong</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Ji‐Hong%22">Liu, Ji‐Hong</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<i> liujihong@mail.hzau.edu.cn</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22New+Phytologist%22">New Phytologist</searchLink>. Aug2026, Vol. 251 Issue 3, p1221-1241. 21p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Histone+acetylation%22">Histone acetylation</searchLink><br /><searchLink fieldCode="DE" term="%22Invertase%22">Invertase</searchLink><br /><searchLink fieldCode="DE" term="%22Plant+epigenetics%22">Plant epigenetics</searchLink><br /><searchLink fieldCode="DE" term="%22Thermal+tolerance+%28Physiology%29%22">Thermal tolerance (Physiology)</searchLink><br /><searchLink fieldCode="DE" term="%22DNA-binding+proteins%22">DNA-binding proteins</searchLink><br /><searchLink fieldCode="DE" term="%22Glucose+metabolism%22">Glucose metabolism</searchLink><br /><searchLink fieldCode="DE" term="%22Epigenetics%22">Epigenetics</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Summary: Sugar metabolism plays a vital role in plant cold tolerance. Histone acetyltransferases (HATs) act as key epigenetic regulators of stress‐responsive genes, yet the function and mechanism underlying HAT‐mediated histone acetylation (HA) in regulation of sugar metabolism under cold stress remain largely unclear.In this study, we demonstrate that PtrAHL14 and PtrAHL17, two cold‐induced AT‐hook motif‐containing nuclear‐localized proteins (AHLs) from Poncirus trifoliata, interact with TATA‐binding protein (TBP)‐Associated Factor 1 (PtrTAF1) and General Control Nonrepressed protein 5 (PtrGCN5), forming a functional quaternary complex at the nuclear matrix. The AHLs recruit PtrTAF1 and PtrGCN5 to the matrix‐associated region of PtrA/NINV7, an alkaline/neutral invertase gene, leading to acetylation of H3K9, H3K14, H3K27, and H4K8 under cold stress. Furthermore, both HATs were found to modulate cold tolerance by cooperatively regulating PtrA/NINV7‐mediated accumulation of reducing sugars.PtrAHL14 and PtrAHL17 directly interact with H3 and H4 and enhance HA, while PtrTAF1 and PtrGCN5 exhibit accumulative effects on triggering HA, thereby amplifying AHL‐mediated regulation of PtrA/NINV7.Taken together, our findings unveil a novel HATs‐AHLs‐A/NINV7 regulatory module that epigenetically controls sucrose catabolism in response to cold stress, providing valuable insights into understanding the molecular regulation of sugar accumulation for improved cold tolerance. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of New Phytologist is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/nph.71215 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 21 StartPage: 1221 Subjects: – SubjectFull: Histone acetylation Type: general – SubjectFull: Invertase Type: general – SubjectFull: Plant epigenetics Type: general – SubjectFull: Thermal tolerance (Physiology) Type: general – SubjectFull: DNA-binding proteins Type: general – SubjectFull: Glucose metabolism Type: general – SubjectFull: Epigenetics Type: general Titles: – TitleFull: TAF1 and GCN5‐mediated histone acetylation of regulatory cascade AHL14/17‐A/NINV7 promotes sucrose catabolism and sugar accumulation for cold tolerance in Citrus. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Dahro, Bachar – PersonEntity: Name: NameFull: Khan, Madiha – PersonEntity: Name: NameFull: Chu, Lele – PersonEntity: Name: NameFull: Zhu, Jian – PersonEntity: Name: NameFull: Shang, Xiangming – PersonEntity: Name: NameFull: Zeng, Xi – PersonEntity: Name: NameFull: Wu, Xiaoyu – PersonEntity: Name: NameFull: Hu, Wenqiang – PersonEntity: Name: NameFull: Lai, Xuelei – PersonEntity: Name: NameFull: Li, Chunlong – PersonEntity: Name: NameFull: Liu, Ji‐Hong IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 08 Text: Aug2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 0028646X Numbering: – Type: volume Value: 251 – Type: issue Value: 3 Titles: – TitleFull: New Phytologist Type: main |
| ResultId | 1 |
