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CircRNA‐Centric ceRNA Network Profiling Reveals Potential Targets of Andrographolide in Murine Ulcerative Colitis.

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Title: CircRNA‐Centric ceRNA Network Profiling Reveals Potential Targets of Andrographolide in Murine Ulcerative Colitis.
Authors: Si, Caijuan1 (AUTHOR), Shu, Long1 (AUTHOR), Cao, Wenjing2 (AUTHOR), Feng, Yuliang3 (AUTHOR), Dong, Hui3 (AUTHOR), He, Xingzhen3 (AUTHOR), Yuan, Jingjing3 (AUTHOR), Li, Songtao1,2 (AUTHOR), Cao, Feiwei2 (AUTHOR) cfw@zcmu.edu.cn, Zhu, Qin1,3 (AUTHOR) zhuqin-1@163.com, Zheng, Peifen1,3 (AUTHOR) kuaidou09@163.com, Bose, Anupama (AUTHOR) abose@wiley.com
Source: Journal of Food Biochemistry. 7/7/2026, Vol. 2026, p1-15. 15p.
Subjects: Circular RNA, Competitive endogenous RNA, Inflammation, Gene expression, Immunoregulation, Ulcerative colitis, Laboratory mice, Andrographis paniculata
Abstract: Andrographolide (Andro) is a major bioactive component of Andrographis paniculata, a medicinal and edible plant with anti‐inflammatory effects. However, its effects against ulcerative colitis (UC) and circRNA‐related mechanism(s) remain unclear. We established the UC mice model by administrating dextran sulfate sodium (DSS) for 14 days. Treatment with Andro for the last 7 days markedly reversed the shortened colon length, decreased the DAI, and abnormal expression of genes related to inflammation and barriers. Besides, sequencing and qRT‐PCR revealed circAsxl2 was upregulated in the DSS group while downregulated after Andro treatment. Moreover, knockdown of circAsxl2 corrected gene expression related to inflammation and barriers in lipopolysaccharide‐induced HT‐29 cells. Then, miRNA and DEmRNAs associated with circAsxl2 were predicted and used to construct a competitive endogenous RNA (ceRNA) network, in which DEmRNAs mRNA was enriched in immune‐related pathways by KEGG. Therefore, Andro possesses the potential to serve as a functional food ingredient for the prevention and management of UC. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Food Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: CircRNA‐Centric ceRNA Network Profiling Reveals Potential Targets of Andrographolide in Murine Ulcerative Colitis.
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  Data: <searchLink fieldCode="AR" term="%22Si%2C+Caijuan%22">Si, Caijuan</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shu%2C+Long%22">Shu, Long</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cao%2C+Wenjing%22">Cao, Wenjing</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Feng%2C+Yuliang%22">Feng, Yuliang</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dong%2C+Hui%22">Dong, Hui</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22He%2C+Xingzhen%22">He, Xingzhen</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yuan%2C+Jingjing%22">Yuan, Jingjing</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Songtao%22">Li, Songtao</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cao%2C+Feiwei%22">Cao, Feiwei</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> cfw@zcmu.edu.cn</i><br /><searchLink fieldCode="AR" term="%22Zhu%2C+Qin%22">Zhu, Qin</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<i> zhuqin-1@163.com</i><br /><searchLink fieldCode="AR" term="%22Zheng%2C+Peifen%22">Zheng, Peifen</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<i> kuaidou09@163.com</i><br /><searchLink fieldCode="AR" term="%22Bose%2C+Anupama%22">Bose, Anupama</searchLink> (AUTHOR)<i> abose@wiley.com</i>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Food+Biochemistry%22">Journal of Food Biochemistry</searchLink>. 7/7/2026, Vol. 2026, p1-15. 15p.
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  Data: <searchLink fieldCode="DE" term="%22Circular+RNA%22">Circular RNA</searchLink><br /><searchLink fieldCode="DE" term="%22Competitive+endogenous+RNA%22">Competitive endogenous RNA</searchLink><br /><searchLink fieldCode="DE" term="%22Inflammation%22">Inflammation</searchLink><br /><searchLink fieldCode="DE" term="%22Gene+expression%22">Gene expression</searchLink><br /><searchLink fieldCode="DE" term="%22Immunoregulation%22">Immunoregulation</searchLink><br /><searchLink fieldCode="DE" term="%22Ulcerative+colitis%22">Ulcerative colitis</searchLink><br /><searchLink fieldCode="DE" term="%22Laboratory+mice%22">Laboratory mice</searchLink><br /><searchLink fieldCode="DE" term="%22Andrographis+paniculata%22">Andrographis paniculata</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Andrographolide (Andro) is a major bioactive component of Andrographis paniculata, a medicinal and edible plant with anti‐inflammatory effects. However, its effects against ulcerative colitis (UC) and circRNA‐related mechanism(s) remain unclear. We established the UC mice model by administrating dextran sulfate sodium (DSS) for 14 days. Treatment with Andro for the last 7 days markedly reversed the shortened colon length, decreased the DAI, and abnormal expression of genes related to inflammation and barriers. Besides, sequencing and qRT‐PCR revealed circAsxl2 was upregulated in the DSS group while downregulated after Andro treatment. Moreover, knockdown of circAsxl2 corrected gene expression related to inflammation and barriers in lipopolysaccharide‐induced HT‐29 cells. Then, miRNA and DEmRNAs associated with circAsxl2 were predicted and used to construct a competitive endogenous RNA (ceRNA) network, in which DEmRNAs mRNA was enriched in immune‐related pathways by KEGG. Therefore, Andro possesses the potential to serve as a functional food ingredient for the prevention and management of UC. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Food Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1155/jfbc/3245873
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 15
        StartPage: 1
    Subjects:
      – SubjectFull: Circular RNA
        Type: general
      – SubjectFull: Competitive endogenous RNA
        Type: general
      – SubjectFull: Inflammation
        Type: general
      – SubjectFull: Gene expression
        Type: general
      – SubjectFull: Immunoregulation
        Type: general
      – SubjectFull: Ulcerative colitis
        Type: general
      – SubjectFull: Laboratory mice
        Type: general
      – SubjectFull: Andrographis paniculata
        Type: general
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      – TitleFull: CircRNA‐Centric ceRNA Network Profiling Reveals Potential Targets of Andrographolide in Murine Ulcerative Colitis.
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              M: 07
              Text: 7/7/2026
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              Y: 2026
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