CircRNA‐Centric ceRNA Network Profiling Reveals Potential Targets of Andrographolide in Murine Ulcerative Colitis.
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| Title: | CircRNA‐Centric ceRNA Network Profiling Reveals Potential Targets of Andrographolide in Murine Ulcerative Colitis. |
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| Authors: | Si, Caijuan1 (AUTHOR), Shu, Long1 (AUTHOR), Cao, Wenjing2 (AUTHOR), Feng, Yuliang3 (AUTHOR), Dong, Hui3 (AUTHOR), He, Xingzhen3 (AUTHOR), Yuan, Jingjing3 (AUTHOR), Li, Songtao1,2 (AUTHOR), Cao, Feiwei2 (AUTHOR) cfw@zcmu.edu.cn, Zhu, Qin1,3 (AUTHOR) zhuqin-1@163.com, Zheng, Peifen1,3 (AUTHOR) kuaidou09@163.com, Bose, Anupama (AUTHOR) abose@wiley.com |
| Source: | Journal of Food Biochemistry. 7/7/2026, Vol. 2026, p1-15. 15p. |
| Subjects: | Circular RNA, Competitive endogenous RNA, Inflammation, Gene expression, Immunoregulation, Ulcerative colitis, Laboratory mice, Andrographis paniculata |
| Abstract: | Andrographolide (Andro) is a major bioactive component of Andrographis paniculata, a medicinal and edible plant with anti‐inflammatory effects. However, its effects against ulcerative colitis (UC) and circRNA‐related mechanism(s) remain unclear. We established the UC mice model by administrating dextran sulfate sodium (DSS) for 14 days. Treatment with Andro for the last 7 days markedly reversed the shortened colon length, decreased the DAI, and abnormal expression of genes related to inflammation and barriers. Besides, sequencing and qRT‐PCR revealed circAsxl2 was upregulated in the DSS group while downregulated after Andro treatment. Moreover, knockdown of circAsxl2 corrected gene expression related to inflammation and barriers in lipopolysaccharide‐induced HT‐29 cells. Then, miRNA and DEmRNAs associated with circAsxl2 were predicted and used to construct a competitive endogenous RNA (ceRNA) network, in which DEmRNAs mRNA was enriched in immune‐related pathways by KEGG. Therefore, Andro possesses the potential to serve as a functional food ingredient for the prevention and management of UC. [ABSTRACT FROM AUTHOR] |
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| Database: | Engineering Source |
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