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Helicobacter pylori promotes dendritic cells maturation and inflammation via outer membrane vesicles.

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Title: Helicobacter pylori promotes dendritic cells maturation and inflammation via outer membrane vesicles.
Authors: Yang, Tianshuo1 (AUTHOR), Dong, Kexin1 (AUTHOR), Wang, Zi1 (AUTHOR), Mi, Chaoyi1 (AUTHOR), Wei, Sisi1,2 (AUTHOR), Li, Xiaoya1,2 (AUTHOR), Shan, Baoen1,2 (AUTHOR), Li, Lei1,2 (AUTHOR) lilei@hebmu.edu.cn, Zhao, Lianmei1,2 (AUTHOR) lianmei555@hebmu.edu.cn
Source: Microbiological Research. Oct2026, Vol. 311, pN.PAG-N.PAG. 1p.
Subjects: Helicobacter pylori, Dendritic cells, Gastric diseases, Inflammation, JAK-STAT pathway, Immune response, Extracellular vesicles, T cells
Abstract: Dendritic cells (DCs) are pivotal in mediating gastric inflammatory responses to Helicobacter pylori (H. pylori), a pathogen that infects half of the global population and contributes to gastric disorders. However, the mechanisms underlying the interaction between DCs and H. pylori remain poorly understood. This study shows that the proportion of mature DCs is significantly increased in gastric mucosal tissues of H. pylori -infected patients. Furthermore, we demonstrate that H. pylori promotes DCs maturation via the secretion of outer membrane vesicles (OMVs). H. pylori OMVs-mediated DCs maturation facilitates the differentiation of T lymphocytes into Th1 and Th17, resulting in the production of pro-inflammatory cytokines. Mechanistically, H. pylori OMVs enhance the binding of phosphorylated STAT3 to COX-2. We further identify that the bacterial effector CagA is partly responsible for OMVs-induced DCs maturation through the STAT3-COX-2-PGE2 pathway. Additionally, H. pylori OMVs augment lactic acid secretion from DCs, which promotes T lymphocytes proliferation and subsequent inflammatory responses. In summary, via OMVs secretion, H. pylori drives DCs maturation, thereby accelerating T lymphocytes activation and promoting pathogenic inflammation. These findings provide important insights for early intervention strategies aimed at eradicating H. pylori infection. [ABSTRACT FROM AUTHOR]
Copyright of Microbiological Research is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 195276726
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Label: Title
  Group: Ti
  Data: Helicobacter pylori promotes dendritic cells maturation and inflammation via outer membrane vesicles.
– Name: Author
  Label: Authors
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  Data: <searchLink fieldCode="AR" term="%22Yang%2C+Tianshuo%22">Yang, Tianshuo</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dong%2C+Kexin%22">Dong, Kexin</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Zi%22">Wang, Zi</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mi%2C+Chaoyi%22">Mi, Chaoyi</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wei%2C+Sisi%22">Wei, Sisi</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Xiaoya%22">Li, Xiaoya</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shan%2C+Baoen%22">Shan, Baoen</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Lei%22">Li, Lei</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> lilei@hebmu.edu.cn</i><br /><searchLink fieldCode="AR" term="%22Zhao%2C+Lianmei%22">Zhao, Lianmei</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> lianmei555@hebmu.edu.cn</i>
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  Data: <searchLink fieldCode="JN" term="%22Microbiological+Research%22">Microbiological Research</searchLink>. Oct2026, Vol. 311, pN.PAG-N.PAG. 1p.
– Name: Subject
  Label: Subjects
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  Data: <searchLink fieldCode="DE" term="%22Helicobacter+pylori%22">Helicobacter pylori</searchLink><br /><searchLink fieldCode="DE" term="%22Dendritic+cells%22">Dendritic cells</searchLink><br /><searchLink fieldCode="DE" term="%22Gastric+diseases%22">Gastric diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Inflammation%22">Inflammation</searchLink><br /><searchLink fieldCode="DE" term="%22JAK-STAT+pathway%22">JAK-STAT pathway</searchLink><br /><searchLink fieldCode="DE" term="%22Immune+response%22">Immune response</searchLink><br /><searchLink fieldCode="DE" term="%22Extracellular+vesicles%22">Extracellular vesicles</searchLink><br /><searchLink fieldCode="DE" term="%22T+cells%22">T cells</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Dendritic cells (DCs) are pivotal in mediating gastric inflammatory responses to Helicobacter pylori (H. pylori), a pathogen that infects half of the global population and contributes to gastric disorders. However, the mechanisms underlying the interaction between DCs and H. pylori remain poorly understood. This study shows that the proportion of mature DCs is significantly increased in gastric mucosal tissues of H. pylori -infected patients. Furthermore, we demonstrate that H. pylori promotes DCs maturation via the secretion of outer membrane vesicles (OMVs). H. pylori OMVs-mediated DCs maturation facilitates the differentiation of T lymphocytes into Th1 and Th17, resulting in the production of pro-inflammatory cytokines. Mechanistically, H. pylori OMVs enhance the binding of phosphorylated STAT3 to COX-2. We further identify that the bacterial effector CagA is partly responsible for OMVs-induced DCs maturation through the STAT3-COX-2-PGE2 pathway. Additionally, H. pylori OMVs augment lactic acid secretion from DCs, which promotes T lymphocytes proliferation and subsequent inflammatory responses. In summary, via OMVs secretion, H. pylori drives DCs maturation, thereby accelerating T lymphocytes activation and promoting pathogenic inflammation. These findings provide important insights for early intervention strategies aimed at eradicating H. pylori infection. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Microbiological Research is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.micres.2026.128598
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 1
        StartPage: N.PAG
    Subjects:
      – SubjectFull: Helicobacter pylori
        Type: general
      – SubjectFull: Dendritic cells
        Type: general
      – SubjectFull: Gastric diseases
        Type: general
      – SubjectFull: Inflammation
        Type: general
      – SubjectFull: JAK-STAT pathway
        Type: general
      – SubjectFull: Immune response
        Type: general
      – SubjectFull: Extracellular vesicles
        Type: general
      – SubjectFull: T cells
        Type: general
    Titles:
      – TitleFull: Helicobacter pylori promotes dendritic cells maturation and inflammation via outer membrane vesicles.
        Type: main
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          Name:
            NameFull: Yang, Tianshuo
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            NameFull: Dong, Kexin
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            NameFull: Wang, Zi
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            NameFull: Mi, Chaoyi
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            NameFull: Wei, Sisi
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            NameFull: Li, Xiaoya
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            NameFull: Li, Lei
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            NameFull: Zhao, Lianmei
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          Dates:
            – D: 01
              M: 10
              Text: Oct2026
              Type: published
              Y: 2026
          Identifiers:
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              Value: 09445013
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              Value: 311
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            – TitleFull: Microbiological Research
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