Physicochemical characterization of ferric carboxymaltose and iron sucrose nanoparticles in human plasma: stability and nanoparticle-protein complex formation.
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| Title: | Physicochemical characterization of ferric carboxymaltose and iron sucrose nanoparticles in human plasma: stability and nanoparticle-protein complex formation. |
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| Authors: | Soliman, Mahmoud G.1 (AUTHOR), Santana-Otero, Antonio1 (AUTHOR), Digigow, Reinaldo2 (AUTHOR), Celayeta, Jesus Maria Frias3 (AUTHOR), Barton Alston, Amy2 (AUTHOR), Flühmann, Beat2 (AUTHOR), Monopoli, Marco P.1 (AUTHOR) marcomonopoli@rcsi.com |
| Source: | Journal of Colloid & Interface Science. Dec2026, Vol. 723, pN.PAG-N.PAG. 1p. |
| Subjects: | Colloidal stability, Nanoparticles, Blood plasma, Blood proteins, Colloid analysis |
| Abstract: | This study investigates the impact of exposure to human blood plasma on the physicochemical properties of two widely used intravenous (IV) iron-carbohydrate nanomedicines for treating iron deficiency and iron deficiency anaemia, ferric carboxymaltose and iron sucrose, with a particular focus on their colloidal stability and protein corona formation. Using dynamic light scattering (DLS), differential centrifugal sedimentation (DCS), size-exclusion chromatography (SEC), inductively coupled plasma mass spectrometry (ICP-MS), sodium dodecyl sulfate–polyacrylamide gel electrophoresis (SDS-PAGE), and density gradient ultracentrifugation (DCS), we compared both iron-carbohydrate nanomedicines before and after plasma exposure. Both products exhibited minimal degradation and negligible protein adsorption and good colloidal stability also after exposure to blood plasma for up to 24 h. However, more pronounced changes in the surface properties of the iron sucrose NPs were observed suggesting rearrangement of the NPs' surface. These findings suggest that the high colloidal stability and low protein interaction of ferric carboxymaltose may contribute to its more sustained pharmacokinetic profile. [Display omitted] [ABSTRACT FROM AUTHOR] |
| Copyright of Journal of Colloid & Interface Science is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 195865712 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Physicochemical characterization of ferric carboxymaltose and iron sucrose nanoparticles in human plasma: stability and nanoparticle-protein complex formation. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Soliman%2C+Mahmoud+G%2E%22">Soliman, Mahmoud G.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Santana-Otero%2C+Antonio%22">Santana-Otero, Antonio</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Digigow%2C+Reinaldo%22">Digigow, Reinaldo</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Celayeta%2C+Jesus+Maria+Frias%22">Celayeta, Jesus Maria Frias</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Barton+Alston%2C+Amy%22">Barton Alston, Amy</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Flühmann%2C+Beat%22">Flühmann, Beat</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Monopoli%2C+Marco+P%2E%22">Monopoli, Marco P.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> marcomonopoli@rcsi.com</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Journal+of+Colloid+%26+Interface+Science%22">Journal of Colloid & Interface Science</searchLink>. Dec2026, Vol. 723, pN.PAG-N.PAG. 1p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Colloidal+stability%22">Colloidal stability</searchLink><br /><searchLink fieldCode="DE" term="%22Nanoparticles%22">Nanoparticles</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+plasma%22">Blood plasma</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+proteins%22">Blood proteins</searchLink><br /><searchLink fieldCode="DE" term="%22Colloid+analysis%22">Colloid analysis</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: This study investigates the impact of exposure to human blood plasma on the physicochemical properties of two widely used intravenous (IV) iron-carbohydrate nanomedicines for treating iron deficiency and iron deficiency anaemia, ferric carboxymaltose and iron sucrose, with a particular focus on their colloidal stability and protein corona formation. Using dynamic light scattering (DLS), differential centrifugal sedimentation (DCS), size-exclusion chromatography (SEC), inductively coupled plasma mass spectrometry (ICP-MS), sodium dodecyl sulfate–polyacrylamide gel electrophoresis (SDS-PAGE), and density gradient ultracentrifugation (DCS), we compared both iron-carbohydrate nanomedicines before and after plasma exposure. Both products exhibited minimal degradation and negligible protein adsorption and good colloidal stability also after exposure to blood plasma for up to 24 h. However, more pronounced changes in the surface properties of the iron sucrose NPs were observed suggesting rearrangement of the NPs' surface. These findings suggest that the high colloidal stability and low protein interaction of ferric carboxymaltose may contribute to its more sustained pharmacokinetic profile. [Display omitted] [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Journal of Colloid & Interface Science is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.jcis.2026.140895 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 1 StartPage: N.PAG Subjects: – SubjectFull: Colloidal stability Type: general – SubjectFull: Nanoparticles Type: general – SubjectFull: Blood plasma Type: general – SubjectFull: Blood proteins Type: general – SubjectFull: Colloid analysis Type: general Titles: – TitleFull: Physicochemical characterization of ferric carboxymaltose and iron sucrose nanoparticles in human plasma: stability and nanoparticle-protein complex formation. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Soliman, Mahmoud G. – PersonEntity: Name: NameFull: Santana-Otero, Antonio – PersonEntity: Name: NameFull: Digigow, Reinaldo – PersonEntity: Name: NameFull: Celayeta, Jesus Maria Frias – PersonEntity: Name: NameFull: Barton Alston, Amy – PersonEntity: Name: NameFull: Flühmann, Beat – PersonEntity: Name: NameFull: Monopoli, Marco P. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 12 Text: Dec2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 00219797 Numbering: – Type: volume Value: 723 Titles: – TitleFull: Journal of Colloid & Interface Science Type: main |
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