View in EDS

Metabolic engineering approaches for lactic acid production

Saved in:
Bibliographic Details
Title: Metabolic engineering approaches for lactic acid production
Authors: Singh, Sudheer K.1, Ahmed, Syed U.1, Pandey, Ashok pandey@csrrltrd.ren.nic.in
Source: Process Biochemistry. May2006, Vol. 41 Issue 5, p991-1000. 10p.
Subjects: Lactic acid, Chemicals, Industrial microbiology, Biochemical engineering
Abstract: Abstract: Lactic acid is an important product of industrial importance. Various approaches using traditional and modern biotechnological approaches have been tried to improve the lactic acid production. The lactic acid bacteria, yeast and fungal systems have been engineered to enhance the lactic acid production. The advent of biotechnology and recognition of industrial applications of lactic acid led to the efforts being focused on use of biotechnological tools to engineer lactic acid bacteria (LAB) and other systems for the production of lactic acid. The initial efforts in LAB genetic modifications were concentrated mostly to develop LAB with enhanced qualities for food grade applications, using traditional approaches. The spontaneous mutations were also attempted by using insertion sequence (IS) elements. The LAB subjected to genetic improvement have been used in dairy industry for flavour enhancement, resistance to bacteriophages, addition of nutritional components and stability and structure of end products. The controlled gene expression systems for industrial gram-positive bacteria with low G+C content have already been reported. However, with the recognition of polylactide as a biodegradable polymer, attempts were directed to reduce the cost of lactic acid production by genetically modifying the organism, by using various cheaply available agro-industrial residues and by process modifications to remove the lactic acid produced during the course of fermentation. The authors here have tried to briefly summaries the various approaches to metabolic engineering used for improving the lactic acid production and cost reduction. [Copyright &y& Elsevier]
Copyright of Process Biochemistry is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
FullText Text:
  Availability: 0
Header DbId: egs
DbLabel: Engineering Source
An: 20259877
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Metabolic engineering approaches for lactic acid production
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Singh%2C+Sudheer+K%2E%22">Singh, Sudheer K.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Ahmed%2C+Syed+U%2E%22">Ahmed, Syed U.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Pandey%2C+Ashok%22">Pandey, Ashok</searchLink><i> pandey@csrrltrd.ren.nic.in</i>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Process+Biochemistry%22">Process Biochemistry</searchLink>. May2006, Vol. 41 Issue 5, p991-1000. 10p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Lactic+acid%22">Lactic acid</searchLink><br /><searchLink fieldCode="DE" term="%22Chemicals%22">Chemicals</searchLink><br /><searchLink fieldCode="DE" term="%22Industrial+microbiology%22">Industrial microbiology</searchLink><br /><searchLink fieldCode="DE" term="%22Biochemical+engineering%22">Biochemical engineering</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Abstract: Lactic acid is an important product of industrial importance. Various approaches using traditional and modern biotechnological approaches have been tried to improve the lactic acid production. The lactic acid bacteria, yeast and fungal systems have been engineered to enhance the lactic acid production. The advent of biotechnology and recognition of industrial applications of lactic acid led to the efforts being focused on use of biotechnological tools to engineer lactic acid bacteria (LAB) and other systems for the production of lactic acid. The initial efforts in LAB genetic modifications were concentrated mostly to develop LAB with enhanced qualities for food grade applications, using traditional approaches. The spontaneous mutations were also attempted by using insertion sequence (IS) elements. The LAB subjected to genetic improvement have been used in dairy industry for flavour enhancement, resistance to bacteriophages, addition of nutritional components and stability and structure of end products. The controlled gene expression systems for industrial gram-positive bacteria with low G+C content have already been reported. However, with the recognition of polylactide as a biodegradable polymer, attempts were directed to reduce the cost of lactic acid production by genetically modifying the organism, by using various cheaply available agro-industrial residues and by process modifications to remove the lactic acid produced during the course of fermentation. The authors here have tried to briefly summaries the various approaches to metabolic engineering used for improving the lactic acid production and cost reduction. [Copyright &y& Elsevier]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Process Biochemistry is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=20259877
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.procbio.2005.12.004
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 10
        StartPage: 991
    Subjects:
      – SubjectFull: Lactic acid
        Type: general
      – SubjectFull: Chemicals
        Type: general
      – SubjectFull: Industrial microbiology
        Type: general
      – SubjectFull: Biochemical engineering
        Type: general
    Titles:
      – TitleFull: Metabolic engineering approaches for lactic acid production
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Singh, Sudheer K.
      – PersonEntity:
          Name:
            NameFull: Ahmed, Syed U.
      – PersonEntity:
          Name:
            NameFull: Pandey, Ashok
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 05
              Text: May2006
              Type: published
              Y: 2006
          Identifiers:
            – Type: issn-print
              Value: 13595113
          Numbering:
            – Type: volume
              Value: 41
            – Type: issue
              Value: 5
          Titles:
            – TitleFull: Process Biochemistry
              Type: main
ResultId 1