The role of radiation therapy in malignant pleural mesothelioma: A systematic review
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| Title: | The role of radiation therapy in malignant pleural mesothelioma: A systematic review |
|---|---|
| Authors: | Ung, Yee C.1 vanderja@mcmaster.ca, Yu, Edward2, Falkson, Conrad3, Haynes, Adam E.4, Stys-Norman, Denise4, Evans, William K.5 |
| Source: | Radiotherapy & Oncology. Jul2006, Vol. 80 Issue 1, p13-18. 6p. |
| Subjects: | Mesothelioma, Radiotherapy, Cancer invasiveness, Human abnormalities |
| Abstract: | Abstract: Introduction: Radiation therapy may offer patients presenting with malignant pleural mesothelioma (MPM) symptom palliation and improvements in quality of life. This systematic review will address the role of radiation therapy in the management of MPM. Methods: A thorough systematic search of the literature was conducted for published articles and conference proceedings for applicable abstracts. Relevant trials were selected and assessed. Results: Three small randomized controlled trials compared prophylactic external beam radiation therapy to no radiation therapy for patients with thoracic tracts caused by drainage tubes or diagnostic procedures. None of those trials reported any serious adverse effects. A pooled analysis found no significant reduction in the frequency of procedure tract metastases. Four non-comparative studies have shown that hemithoracic irradiation alone resulted in significant toxicity, including radiation-induced pulmonary fibrosis, radiation pneumonitis, and bronchopleural fistula, without any survival benefit. Few of the identified studies reported on symptom control, and no studies included formal measures of quality of life. Conclusion: There is limited evidence for the role of radiotherapy in the management of patients with MPM. Future studies including radiotherapy for the treatment of such patients should include formal measures of quality of life and symptom control. [Copyright &y& Elsevier] |
| Copyright of Radiotherapy & Oncology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 22009877 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: The role of radiation therapy in malignant pleural mesothelioma: A systematic review – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Ung%2C+Yee+C%2E%22">Ung, Yee C.</searchLink><relatesTo>1</relatesTo><i> vanderja@mcmaster.ca</i><br /><searchLink fieldCode="AR" term="%22Yu%2C+Edward%22">Yu, Edward</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Falkson%2C+Conrad%22">Falkson, Conrad</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Haynes%2C+Adam+E%2E%22">Haynes, Adam E.</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Stys-Norman%2C+Denise%22">Stys-Norman, Denise</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Evans%2C+William+K%2E%22">Evans, William K.</searchLink><relatesTo>5</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Radiotherapy+%26+Oncology%22">Radiotherapy & Oncology</searchLink>. Jul2006, Vol. 80 Issue 1, p13-18. 6p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Mesothelioma%22">Mesothelioma</searchLink><br /><searchLink fieldCode="DE" term="%22Radiotherapy%22">Radiotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+invasiveness%22">Cancer invasiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Human+abnormalities%22">Human abnormalities</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Abstract: Introduction: Radiation therapy may offer patients presenting with malignant pleural mesothelioma (MPM) symptom palliation and improvements in quality of life. This systematic review will address the role of radiation therapy in the management of MPM. Methods: A thorough systematic search of the literature was conducted for published articles and conference proceedings for applicable abstracts. Relevant trials were selected and assessed. Results: Three small randomized controlled trials compared prophylactic external beam radiation therapy to no radiation therapy for patients with thoracic tracts caused by drainage tubes or diagnostic procedures. None of those trials reported any serious adverse effects. A pooled analysis found no significant reduction in the frequency of procedure tract metastases. Four non-comparative studies have shown that hemithoracic irradiation alone resulted in significant toxicity, including radiation-induced pulmonary fibrosis, radiation pneumonitis, and bronchopleural fistula, without any survival benefit. Few of the identified studies reported on symptom control, and no studies included formal measures of quality of life. Conclusion: There is limited evidence for the role of radiotherapy in the management of patients with MPM. Future studies including radiotherapy for the treatment of such patients should include formal measures of quality of life and symptom control. [Copyright &y& Elsevier] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Radiotherapy & Oncology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.radonc.2006.06.002 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 6 StartPage: 13 Subjects: – SubjectFull: Mesothelioma Type: general – SubjectFull: Radiotherapy Type: general – SubjectFull: Cancer invasiveness Type: general – SubjectFull: Human abnormalities Type: general Titles: – TitleFull: The role of radiation therapy in malignant pleural mesothelioma: A systematic review Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Ung, Yee C. – PersonEntity: Name: NameFull: Yu, Edward – PersonEntity: Name: NameFull: Falkson, Conrad – PersonEntity: Name: NameFull: Haynes, Adam E. – PersonEntity: Name: NameFull: Stys-Norman, Denise – PersonEntity: Name: NameFull: Evans, William K. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: Jul2006 Type: published Y: 2006 Identifiers: – Type: issn-print Value: 01678140 Numbering: – Type: volume Value: 80 – Type: issue Value: 1 Titles: – TitleFull: Radiotherapy & Oncology Type: main |
| ResultId | 1 |
