Serotonergic Inhibition of Intense Jumping Behavior in Mice Lacking PACAP ( Adcyap1−/−).
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| Title: | Serotonergic Inhibition of Intense Jumping Behavior in Mice Lacking PACAP ( Adcyap1−/−). |
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| Authors: | SHINTANI, NORIHITO1 (AUTHOR), HASHIMOTO, HITOSHI1 (AUTHOR), TANAKA, KAZUHIRO1 (AUTHOR), KAWAGISHI, NAOFUMI1 (AUTHOR), KAWAGUCHI, CHIHIRO1 (AUTHOR), HATANAKA, MICHIYOSHI1 (AUTHOR), AGO, YUKIO1,2 (AUTHOR), MATSUDA, TOSHIO2 (AUTHOR), BABA, AKEMICHI1 (AUTHOR) |
| Source: | Annals of the New York Academy of Sciences. 2006, Vol. 1070 Issue 1, p545-549. 5p. 1 Graph. |
| Subjects: | Peptides, Behavior, Serotonin uptake inhibitors, Neurotransmitter uptake inhibitors, Serotonin |
| Abstract: | Genetic manipulation of pituitary adenylate cyclase-activating polypeptide (PACAP) in mice has uncovered its involvement in psychomotor function. We previously observed that mice lacking the Adcyap1 gene encoding the neuropeptide PACAP ( Adcyap1−/−) displayed intense jumping behavior when placed in a novel environment such as an open field. Here, we show that Adcyap1−/− mice manifest jumping behavior as early as at least 6 weeks of age when compared with wild-type mice and that the selective serotonin (5-HT) reuptake inhibitor, fluoxetine, as well as the serotonin precursor, 5-hydroxytryptophan, suppress jumping behavior. Our previous study showed a slight decrease in 5-HT metabolite, 5-hydroxyindoleacetic acid (5-HIAA) in Adcyap1−/− mouse brain. Taken together, these results suggest that there is a developmental aspect to the jumping behavior seen in Adcyap1−/− mice, and that jumping behaviour may involve the serotonergic system. [ABSTRACT FROM AUTHOR] |
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| Database: | Engineering Source |
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| Abstract: | Genetic manipulation of pituitary adenylate cyclase-activating polypeptide (PACAP) in mice has uncovered its involvement in psychomotor function. We previously observed that mice lacking the Adcyap1 gene encoding the neuropeptide PACAP ( Adcyap1−/−) displayed intense jumping behavior when placed in a novel environment such as an open field. Here, we show that Adcyap1−/− mice manifest jumping behavior as early as at least 6 weeks of age when compared with wild-type mice and that the selective serotonin (5-HT) reuptake inhibitor, fluoxetine, as well as the serotonin precursor, 5-hydroxytryptophan, suppress jumping behavior. Our previous study showed a slight decrease in 5-HT metabolite, 5-hydroxyindoleacetic acid (5-HIAA) in Adcyap1−/− mouse brain. Taken together, these results suggest that there is a developmental aspect to the jumping behavior seen in Adcyap1−/− mice, and that jumping behaviour may involve the serotonergic system. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 00778923 |
| DOI: | 10.1196/annals.1317.079 |
