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Serotonergic Inhibition of Intense Jumping Behavior in Mice Lacking PACAP ( Adcyap1−/−).

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Title: Serotonergic Inhibition of Intense Jumping Behavior in Mice Lacking PACAP ( Adcyap1−/−).
Authors: SHINTANI, NORIHITO1 (AUTHOR), HASHIMOTO, HITOSHI1 (AUTHOR), TANAKA, KAZUHIRO1 (AUTHOR), KAWAGISHI, NAOFUMI1 (AUTHOR), KAWAGUCHI, CHIHIRO1 (AUTHOR), HATANAKA, MICHIYOSHI1 (AUTHOR), AGO, YUKIO1,2 (AUTHOR), MATSUDA, TOSHIO2 (AUTHOR), BABA, AKEMICHI1 (AUTHOR)
Source: Annals of the New York Academy of Sciences. 2006, Vol. 1070 Issue 1, p545-549. 5p. 1 Graph.
Subjects: Peptides, Behavior, Serotonin uptake inhibitors, Neurotransmitter uptake inhibitors, Serotonin
Abstract: Genetic manipulation of pituitary adenylate cyclase-activating polypeptide (PACAP) in mice has uncovered its involvement in psychomotor function. We previously observed that mice lacking the Adcyap1 gene encoding the neuropeptide PACAP ( Adcyap1−/−) displayed intense jumping behavior when placed in a novel environment such as an open field. Here, we show that Adcyap1−/− mice manifest jumping behavior as early as at least 6 weeks of age when compared with wild-type mice and that the selective serotonin (5-HT) reuptake inhibitor, fluoxetine, as well as the serotonin precursor, 5-hydroxytryptophan, suppress jumping behavior. Our previous study showed a slight decrease in 5-HT metabolite, 5-hydroxyindoleacetic acid (5-HIAA) in Adcyap1−/− mouse brain. Taken together, these results suggest that there is a developmental aspect to the jumping behavior seen in Adcyap1−/− mice, and that jumping behaviour may involve the serotonergic system. [ABSTRACT FROM AUTHOR]
Copyright of Annals of the New York Academy of Sciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Serotonergic Inhibition of Intense Jumping Behavior in Mice Lacking PACAP ( Adcyap1<superscript>−/−</superscript>).
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  Data: <searchLink fieldCode="AR" term="%22SHINTANI%2C+NORIHITO%22">SHINTANI, NORIHITO</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22HASHIMOTO%2C+HITOSHI%22">HASHIMOTO, HITOSHI</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22TANAKA%2C+KAZUHIRO%22">TANAKA, KAZUHIRO</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22KAWAGISHI%2C+NAOFUMI%22">KAWAGISHI, NAOFUMI</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22KAWAGUCHI%2C+CHIHIRO%22">KAWAGUCHI, CHIHIRO</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22HATANAKA%2C+MICHIYOSHI%22">HATANAKA, MICHIYOSHI</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22AGO%2C+YUKIO%22">AGO, YUKIO</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22MATSUDA%2C+TOSHIO%22">MATSUDA, TOSHIO</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22BABA%2C+AKEMICHI%22">BABA, AKEMICHI</searchLink><relatesTo>1</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Annals+of+the+New+York+Academy+of+Sciences%22">Annals of the New York Academy of Sciences</searchLink>. 2006, Vol. 1070 Issue 1, p545-549. 5p. 1 Graph.
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  Data: <searchLink fieldCode="DE" term="%22Peptides%22">Peptides</searchLink><br /><searchLink fieldCode="DE" term="%22Behavior%22">Behavior</searchLink><br /><searchLink fieldCode="DE" term="%22Serotonin+uptake+inhibitors%22">Serotonin uptake inhibitors</searchLink><br /><searchLink fieldCode="DE" term="%22Neurotransmitter+uptake+inhibitors%22">Neurotransmitter uptake inhibitors</searchLink><br /><searchLink fieldCode="DE" term="%22Serotonin%22">Serotonin</searchLink>
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  Data: Genetic manipulation of pituitary adenylate cyclase-activating polypeptide (PACAP) in mice has uncovered its involvement in psychomotor function. We previously observed that mice lacking the Adcyap1 gene encoding the neuropeptide PACAP ( Adcyap1−/−) displayed intense jumping behavior when placed in a novel environment such as an open field. Here, we show that Adcyap1−/− mice manifest jumping behavior as early as at least 6 weeks of age when compared with wild-type mice and that the selective serotonin (5-HT) reuptake inhibitor, fluoxetine, as well as the serotonin precursor, 5-hydroxytryptophan, suppress jumping behavior. Our previous study showed a slight decrease in 5-HT metabolite, 5-hydroxyindoleacetic acid (5-HIAA) in Adcyap1−/− mouse brain. Taken together, these results suggest that there is a developmental aspect to the jumping behavior seen in Adcyap1−/− mice, and that jumping behaviour may involve the serotonergic system. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Annals of the New York Academy of Sciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1196/annals.1317.079
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        Text: English
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      – SubjectFull: Peptides
        Type: general
      – SubjectFull: Behavior
        Type: general
      – SubjectFull: Serotonin uptake inhibitors
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      – SubjectFull: Neurotransmitter uptake inhibitors
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      – SubjectFull: Serotonin
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      – TitleFull: Serotonergic Inhibition of Intense Jumping Behavior in Mice Lacking PACAP ( Adcyap1−/−).
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              M: 07
              Text: 2006
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