XPS and bioactivity study of the bisphosphonate pamidronate adsorbed onto plasma sprayed hydroxyapatite coatings
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| Title: | XPS and bioactivity study of the bisphosphonate pamidronate adsorbed onto plasma sprayed hydroxyapatite coatings |
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| Authors: | McLeod, Kate1, Kumar, Sunil1 sunil.kumar@unisa.edu.au, Smart, Roger St.C.2, Dutta, Naba1, Voelcker, Nicolas H.3, Anderson, Gail I.4, Sekel, Ron5 |
| Source: | Applied Surface Science. Dec2006, Vol. 253 Issue 5, p2644-2651. 8p. |
| Subjects: | Coating processes, Spectrum analysis, Separation (Technology), Protective coatings |
| Abstract: | Abstract: This paper reports the use of X-ray photoelectron spectroscopy (XPS) to investigate bisphosphonate (BP) adsorption onto plasma sprayed hydroxyapatite (HA) coatings commonly used for orthopaedic implants. BPs exhibit high binding affinity for the calcium present in HA and hence can be adsorbed onto HA-coated implants to exploit their beneficial properties for improved bone growth at the implant interface. A rigorous XPS analysis of pamidronate, a commonly used nitrogenous BP, adsorbed onto plasma sprayed HA-coated cobalt–chromium substrates has been carried out, aimed at: (a) confirming the adsorption of this BP onto HA; (b) studying the BP diffusion profile in the HA coating by employing the technique of XPS depth profiling; (c) confirming the bioactivity of the adsorbed BP. XPS spectra of plasma sprayed HA-coated discs exposed to a 10mM aqueous BP solution (pamidronate) for periods of 1, 2 and 24h showed nitrogen and phosphorous photoelectron signals corresponding to the BP, confirming its adsorption onto the HA substrate. XPS depth profiling of the 2h BP-exposed HA discs showed penetration of the BP into the HA matrix to depths of at least 260nm. The bioactivity of the adsorbed BP was confirmed by the observed inhibition of osteoclast (bone resorbing) cell activity. In comparison to the HA sample, the HA sample with adsorbed BP exhibited a 25-fold decrease in primary osteoclast cells. [Copyright &y& Elsevier] |
| Copyright of Applied Surface Science is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 23278831 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: XPS and bioactivity study of the bisphosphonate pamidronate adsorbed onto plasma sprayed hydroxyapatite coatings – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22McLeod%2C+Kate%22">McLeod, Kate</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Kumar%2C+Sunil%22">Kumar, Sunil</searchLink><relatesTo>1</relatesTo><i> sunil.kumar@unisa.edu.au</i><br /><searchLink fieldCode="AR" term="%22Smart%2C+Roger+St%2EC%2E%22">Smart, Roger St.C.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Dutta%2C+Naba%22">Dutta, Naba</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Voelcker%2C+Nicolas+H%2E%22">Voelcker, Nicolas H.</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Anderson%2C+Gail+I%2E%22">Anderson, Gail I.</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Sekel%2C+Ron%22">Sekel, Ron</searchLink><relatesTo>5</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Applied+Surface+Science%22">Applied Surface Science</searchLink>. Dec2006, Vol. 253 Issue 5, p2644-2651. 8p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Coating+processes%22">Coating processes</searchLink><br /><searchLink fieldCode="DE" term="%22Spectrum+analysis%22">Spectrum analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Separation+%28Technology%29%22">Separation (Technology)</searchLink><br /><searchLink fieldCode="DE" term="%22Protective+coatings%22">Protective coatings</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Abstract: This paper reports the use of X-ray photoelectron spectroscopy (XPS) to investigate bisphosphonate (BP) adsorption onto plasma sprayed hydroxyapatite (HA) coatings commonly used for orthopaedic implants. BPs exhibit high binding affinity for the calcium present in HA and hence can be adsorbed onto HA-coated implants to exploit their beneficial properties for improved bone growth at the implant interface. A rigorous XPS analysis of pamidronate, a commonly used nitrogenous BP, adsorbed onto plasma sprayed HA-coated cobalt–chromium substrates has been carried out, aimed at: (a) confirming the adsorption of this BP onto HA; (b) studying the BP diffusion profile in the HA coating by employing the technique of XPS depth profiling; (c) confirming the bioactivity of the adsorbed BP. XPS spectra of plasma sprayed HA-coated discs exposed to a 10mM aqueous BP solution (pamidronate) for periods of 1, 2 and 24h showed nitrogen and phosphorous photoelectron signals corresponding to the BP, confirming its adsorption onto the HA substrate. XPS depth profiling of the 2h BP-exposed HA discs showed penetration of the BP into the HA matrix to depths of at least 260nm. The bioactivity of the adsorbed BP was confirmed by the observed inhibition of osteoclast (bone resorbing) cell activity. In comparison to the HA sample, the HA sample with adsorbed BP exhibited a 25-fold decrease in primary osteoclast cells. [Copyright &y& Elsevier] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Applied Surface Science is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.apsusc.2006.05.031 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 2644 Subjects: – SubjectFull: Coating processes Type: general – SubjectFull: Spectrum analysis Type: general – SubjectFull: Separation (Technology) Type: general – SubjectFull: Protective coatings Type: general Titles: – TitleFull: XPS and bioactivity study of the bisphosphonate pamidronate adsorbed onto plasma sprayed hydroxyapatite coatings Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: McLeod, Kate – PersonEntity: Name: NameFull: Kumar, Sunil – PersonEntity: Name: NameFull: Smart, Roger St.C. – PersonEntity: Name: NameFull: Dutta, Naba – PersonEntity: Name: NameFull: Voelcker, Nicolas H. – PersonEntity: Name: NameFull: Anderson, Gail I. – PersonEntity: Name: NameFull: Sekel, Ron IsPartOfRelationships: – BibEntity: Dates: – D: 30 M: 12 Text: Dec2006 Type: published Y: 2006 Identifiers: – Type: issn-print Value: 01694332 Numbering: – Type: volume Value: 253 – Type: issue Value: 5 Titles: – TitleFull: Applied Surface Science Type: main |
| ResultId | 1 |
