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A Sakurai-Prins-Ritter Sequence for the Three-Component Diastereoselective Synthesis of 4-Amino Tetrahydropyrans.

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Bibliographic Details
Title: A Sakurai-Prins-Ritter Sequence for the Three-Component Diastereoselective Synthesis of 4-Amino Tetrahydropyrans.
Authors: Epstein, Oleg L.1, Rovis, Tomislav1 rovis@lamar.colostate.edu
Source: Journal of the American Chemical Society. 12/27/2006, Vol. 128 Issue 51, p16480-16481. 2p.
Subjects: Chemical research, Amino acids, Amino acid sequence, Cookware, Cations
Abstract: The article focuses on the one-pot sakurai-prins-ritter reaction in highly disastereoselective preparation of four-amino tetrahydropyrans procedure. The utilization of ritter reaction to quench the four-tetrahydropyranyl cation is successful with the overall sequence proceeding in excellent diastereoselectivity. A single stereocenter present in hydroxyacid starting material can controll up to four new stereocenters.
Database: Engineering Source
Description
Abstract:The article focuses on the one-pot sakurai-prins-ritter reaction in highly disastereoselective preparation of four-amino tetrahydropyrans procedure. The utilization of ritter reaction to quench the four-tetrahydropyranyl cation is successful with the overall sequence proceeding in excellent diastereoselectivity. A single stereocenter present in hydroxyacid starting material can controll up to four new stereocenters.
ISSN:00027863
DOI:10.1021/ja066794k