A Sakurai-Prins-Ritter Sequence for the Three-Component Diastereoselective Synthesis of 4-Amino Tetrahydropyrans.
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| Title: | A Sakurai-Prins-Ritter Sequence for the Three-Component Diastereoselective Synthesis of 4-Amino Tetrahydropyrans. |
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| Authors: | Epstein, Oleg L.1, Rovis, Tomislav1 rovis@lamar.colostate.edu |
| Source: | Journal of the American Chemical Society. 12/27/2006, Vol. 128 Issue 51, p16480-16481. 2p. |
| Subjects: | Chemical research, Amino acids, Amino acid sequence, Cookware, Cations |
| Abstract: | The article focuses on the one-pot sakurai-prins-ritter reaction in highly disastereoselective preparation of four-amino tetrahydropyrans procedure. The utilization of ritter reaction to quench the four-tetrahydropyranyl cation is successful with the overall sequence proceeding in excellent diastereoselectivity. A single stereocenter present in hydroxyacid starting material can controll up to four new stereocenters. |
| Database: | Engineering Source |
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