View in EDS

Gender differences in germ-cell mutagenesis and genetic risk

Saved in:
Bibliographic Details
Title: Gender differences in germ-cell mutagenesis and genetic risk
Authors: Eichenlaub-Ritter, Ursula1 EiRi@uni-bielefeld.de, Adler, Ilse-Dore2, Carere, Angelo3, Pacchierotti, Francesca4
Source: Environmental Research. May2007, Vol. 104 Issue 1, p22-36. 15p.
Subjects: Sex differences (Biology), Gender studies, Chemicals, Mutagens, Germ cells, Health risk assessment, Mutagenicity testing, Genetic epidemiology, Molecular epidemiology, Chronic toxicity testing, International cooperation
Abstract: Current international classification systems for chemical mutagens are hazard-based rather than aimed at assessing risks quantitatively. In the past, germ-cell tests have been mainly performed with a limited number of somatic cell mutagens, and rarely under conditions aimed at comparing gender-specific differences in susceptibility to mutagen exposures. There are profound differences in the genetic constitution, and in hormonal, structural, and functional aspects of differentiation and control of gametogenesis between the sexes. A critical review of the literature suggests that these differences may have a profound impact on the relative susceptibility, stage of highest sensitivity and the relative risk for the genesis of gene mutation, as well as structural and numerical chromosomal aberrations in male and female germ cells. Transmission of germ-cell mutations to the offspring may also encounter gender-specific influences. Gender differences in susceptibility to chemically derived alterations in imprinting patterns may pose a threat for the health of the offspring and may also be transmitted to future generations. Recent reports on different genetic effects from high acute and from chronic low-dose exposures challenge the validity of conclusions drawn from standard methods of mutagenicity testing. In conclusion, research is urgently needed to identify genetic hazards for a larger range of chemical compounds, including those suspected to disturb proper chromosome segregation. Alterations in epigenetic programming and their health consequences will have to be investigated. More attention should be paid to gender-specific genetic effects. Finally, the database for germ-cell mutagens should be enlarged using molecular methodologies, and genetic epidemiology studies should be performed with these techniques to verify human genetic risk. [Copyright &y& Elsevier]
Copyright of Environmental Research is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
FullText Text:
  Availability: 0
Header DbId: egs
DbLabel: Engineering Source
An: 24697475
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Gender differences in germ-cell mutagenesis and genetic risk
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Eichenlaub-Ritter%2C+Ursula%22">Eichenlaub-Ritter, Ursula</searchLink><relatesTo>1</relatesTo><i> EiRi@uni-bielefeld.de</i><br /><searchLink fieldCode="AR" term="%22Adler%2C+Ilse-Dore%22">Adler, Ilse-Dore</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Carere%2C+Angelo%22">Carere, Angelo</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Pacchierotti%2C+Francesca%22">Pacchierotti, Francesca</searchLink><relatesTo>4</relatesTo>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Environmental+Research%22">Environmental Research</searchLink>. May2007, Vol. 104 Issue 1, p22-36. 15p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Sex+differences+%28Biology%29%22">Sex differences (Biology)</searchLink><br /><searchLink fieldCode="DE" term="%22Gender+studies%22">Gender studies</searchLink><br /><searchLink fieldCode="DE" term="%22Chemicals%22">Chemicals</searchLink><br /><searchLink fieldCode="DE" term="%22Mutagens%22">Mutagens</searchLink><br /><searchLink fieldCode="DE" term="%22Germ+cells%22">Germ cells</searchLink><br /><searchLink fieldCode="DE" term="%22Health+risk+assessment%22">Health risk assessment</searchLink><br /><searchLink fieldCode="DE" term="%22Mutagenicity+testing%22">Mutagenicity testing</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+epidemiology%22">Genetic epidemiology</searchLink><br /><searchLink fieldCode="DE" term="%22Molecular+epidemiology%22">Molecular epidemiology</searchLink><br /><searchLink fieldCode="DE" term="%22Chronic+toxicity+testing%22">Chronic toxicity testing</searchLink><br /><searchLink fieldCode="DE" term="%22International+cooperation%22">International cooperation</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Current international classification systems for chemical mutagens are hazard-based rather than aimed at assessing risks quantitatively. In the past, germ-cell tests have been mainly performed with a limited number of somatic cell mutagens, and rarely under conditions aimed at comparing gender-specific differences in susceptibility to mutagen exposures. There are profound differences in the genetic constitution, and in hormonal, structural, and functional aspects of differentiation and control of gametogenesis between the sexes. A critical review of the literature suggests that these differences may have a profound impact on the relative susceptibility, stage of highest sensitivity and the relative risk for the genesis of gene mutation, as well as structural and numerical chromosomal aberrations in male and female germ cells. Transmission of germ-cell mutations to the offspring may also encounter gender-specific influences. Gender differences in susceptibility to chemically derived alterations in imprinting patterns may pose a threat for the health of the offspring and may also be transmitted to future generations. Recent reports on different genetic effects from high acute and from chronic low-dose exposures challenge the validity of conclusions drawn from standard methods of mutagenicity testing. In conclusion, research is urgently needed to identify genetic hazards for a larger range of chemical compounds, including those suspected to disturb proper chromosome segregation. Alterations in epigenetic programming and their health consequences will have to be investigated. More attention should be paid to gender-specific genetic effects. Finally, the database for germ-cell mutagens should be enlarged using molecular methodologies, and genetic epidemiology studies should be performed with these techniques to verify human genetic risk. [Copyright &y& Elsevier]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Environmental Research is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=24697475
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.envres.2006.10.002
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 15
        StartPage: 22
    Subjects:
      – SubjectFull: Sex differences (Biology)
        Type: general
      – SubjectFull: Gender studies
        Type: general
      – SubjectFull: Chemicals
        Type: general
      – SubjectFull: Mutagens
        Type: general
      – SubjectFull: Germ cells
        Type: general
      – SubjectFull: Health risk assessment
        Type: general
      – SubjectFull: Mutagenicity testing
        Type: general
      – SubjectFull: Genetic epidemiology
        Type: general
      – SubjectFull: Molecular epidemiology
        Type: general
      – SubjectFull: Chronic toxicity testing
        Type: general
      – SubjectFull: International cooperation
        Type: general
    Titles:
      – TitleFull: Gender differences in germ-cell mutagenesis and genetic risk
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Eichenlaub-Ritter, Ursula
      – PersonEntity:
          Name:
            NameFull: Adler, Ilse-Dore
      – PersonEntity:
          Name:
            NameFull: Carere, Angelo
      – PersonEntity:
          Name:
            NameFull: Pacchierotti, Francesca
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 05
              Text: May2007
              Type: published
              Y: 2007
          Identifiers:
            – Type: issn-print
              Value: 00139351
          Numbering:
            – Type: volume
              Value: 104
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Environmental Research
              Type: main
ResultId 1