New bioerodable thermoresponsive polymers for possible radiotherapeutic applications
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| Title: | New bioerodable thermoresponsive polymers for possible radiotherapeutic applications |
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| Authors: | Hruby, Martin1 mhruby@centrum.cz, Kucka, Jan2, Lebeda, Ondrej2, Mackova, Hana1, Babic, Michal1, Konak, Cestmir1, Studenovsky, Martin1, Sikora, Antonin1, Kozempel, Jan2, Ulbrich, Karel1 |
| Source: | Journal of Controlled Release. May2007, Vol. 119 Issue 1, p25-33. 9p. |
| Subjects: | Radiotherapy, Radioisotopes, Hydrolysis, Hydrazones |
| Abstract: | Abstract: A new thermoresponsive system designed for local radiotherapy has been developed. In this system a radionuclide complex is entrapped in a thermoresponsive polymer locally precipitated at body temperature after injection of a polymer–complex solution into the tissue where a therapeutic effect is required. The lifetime of the system is controlled by the rate of polymer hydrolysis, its dissolution and elimination from the body. The thermoresponsive polymer with the cloud temperature (CT) below body temperature is based on copolymers of N-isopropylmethacrylamide with a methacrylamide-type comonomer containing hydrophobic n-alkyls of three different sizes (C3, C6 and C12) bonded by a hydrolytically labile hydrazone bond. Hydrolysis of hydrazone bond results in a copolymer soluble at body temperature. The copolymer containing 27.5 mole% of the comonomer with the C6 moiety, which was chosen for further study, has the CT 22 °C and its phase separation is complete at 34 °C. Polymer dissolution is complete within 48 h at both pH 5.0 or 7.4. The model therapeutic radionuclide, 64Cu, in the form of its hydrophobic chelate bis(quinolin-8-olato-N,O) [64Cu]copper, is efficiently kept hydrophobically entrapped in the phase-separated polymer until the dissolution by hydrolytic degradation is completed. [Copyright &y& Elsevier] |
| Copyright of Journal of Controlled Release is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 24783160 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: New bioerodable thermoresponsive polymers for possible radiotherapeutic applications – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Hruby%2C+Martin%22">Hruby, Martin</searchLink><relatesTo>1</relatesTo><i> mhruby@centrum.cz</i><br /><searchLink fieldCode="AR" term="%22Kucka%2C+Jan%22">Kucka, Jan</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Lebeda%2C+Ondrej%22">Lebeda, Ondrej</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Mackova%2C+Hana%22">Mackova, Hana</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Babic%2C+Michal%22">Babic, Michal</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Konak%2C+Cestmir%22">Konak, Cestmir</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Studenovsky%2C+Martin%22">Studenovsky, Martin</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Sikora%2C+Antonin%22">Sikora, Antonin</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Kozempel%2C+Jan%22">Kozempel, Jan</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Ulbrich%2C+Karel%22">Ulbrich, Karel</searchLink><relatesTo>1</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Journal+of+Controlled+Release%22">Journal of Controlled Release</searchLink>. May2007, Vol. 119 Issue 1, p25-33. 9p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Radiotherapy%22">Radiotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22Radioisotopes%22">Radioisotopes</searchLink><br /><searchLink fieldCode="DE" term="%22Hydrolysis%22">Hydrolysis</searchLink><br /><searchLink fieldCode="DE" term="%22Hydrazones%22">Hydrazones</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Abstract: A new thermoresponsive system designed for local radiotherapy has been developed. In this system a radionuclide complex is entrapped in a thermoresponsive polymer locally precipitated at body temperature after injection of a polymer–complex solution into the tissue where a therapeutic effect is required. The lifetime of the system is controlled by the rate of polymer hydrolysis, its dissolution and elimination from the body. The thermoresponsive polymer with the cloud temperature (CT) below body temperature is based on copolymers of N-isopropylmethacrylamide with a methacrylamide-type comonomer containing hydrophobic n-alkyls of three different sizes (C3, C6 and C12) bonded by a hydrolytically labile hydrazone bond. Hydrolysis of hydrazone bond results in a copolymer soluble at body temperature. The copolymer containing 27.5 mole% of the comonomer with the C6 moiety, which was chosen for further study, has the CT 22 °C and its phase separation is complete at 34 °C. Polymer dissolution is complete within 48 h at both pH 5.0 or 7.4. The model therapeutic radionuclide, 64Cu, in the form of its hydrophobic chelate bis(quinolin-8-olato-N,O) [64Cu]copper, is efficiently kept hydrophobically entrapped in the phase-separated polymer until the dissolution by hydrolytic degradation is completed. [Copyright &y& Elsevier] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Journal of Controlled Release is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.jconrel.2007.02.009 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 25 Subjects: – SubjectFull: Radiotherapy Type: general – SubjectFull: Radioisotopes Type: general – SubjectFull: Hydrolysis Type: general – SubjectFull: Hydrazones Type: general Titles: – TitleFull: New bioerodable thermoresponsive polymers for possible radiotherapeutic applications Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Hruby, Martin – PersonEntity: Name: NameFull: Kucka, Jan – PersonEntity: Name: NameFull: Lebeda, Ondrej – PersonEntity: Name: NameFull: Mackova, Hana – PersonEntity: Name: NameFull: Babic, Michal – PersonEntity: Name: NameFull: Konak, Cestmir – PersonEntity: Name: NameFull: Studenovsky, Martin – PersonEntity: Name: NameFull: Sikora, Antonin – PersonEntity: Name: NameFull: Kozempel, Jan – PersonEntity: Name: NameFull: Ulbrich, Karel IsPartOfRelationships: – BibEntity: Dates: – D: 14 M: 05 Text: May2007 Type: published Y: 2007 Identifiers: – Type: issn-print Value: 01683659 Numbering: – Type: volume Value: 119 – Type: issue Value: 1 Titles: – TitleFull: Journal of Controlled Release Type: main |
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