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Validation of task-related excess of spike coincidences based on NeuroXidence

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Title: Validation of task-related excess of spike coincidences based on NeuroXidence
Authors: Pipa, Gordon1 pipa@mpih-frankfurt.mpg.de, Riehle, Alexa2, Grün, Sonja3,4
Source: Neurocomputing. Jun2007, Vol. 70 Issue 10-12, p2064-2068. 5p.
Subjects: Motor cortex, Frontal lobe, Action potentials, Electrophysiology, Computational neuroscience, Neurons
Abstract: One of the key findings supporting the assembly hypothesis was found in recordings from the primary motor cortex of behaving monkeys involved in a delayed pointing task [A. Riehle, S. Grün, M. Diesmann, A. Aertsen, Spike synchronization and rate modulation differentially involved in motor cortical function, Science 278 (1997) 1950–1953]. Based on the unitary event (‘UE’) method, the authors have shown that excess coincidences between simultaneously recorded neurons occur dynamically at behaviorally relevant points in time. However, sensitivity of the UE method for non-stationarities and regularity of spike trains caused fear that the results presented might be, at least in part, false positives. We reanalyzed the same data with the new non-parametric method NeuroXidence, which is robust against firing-rate modulations, rate changes across trials, regularity or burstiness, as well as low rates. Our results based on NeuroXidence confirm the results presented in Riehle et al. [Spike synchronization and rate modulation differentially involved in motor cortical function, Science 278 (1997) 1950–1953] and demonstrate behaviorally modulated excesses of coincidences on a time scale of 3–5ms. [Copyright &y& Elsevier]
Copyright of Neurocomputing is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
An: 24863824
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PubTypeId: academicJournal
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  Data: Validation of task-related excess of spike coincidences based on NeuroXidence
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  Data: One of the key findings supporting the assembly hypothesis was found in recordings from the primary motor cortex of behaving monkeys involved in a delayed pointing task [A. Riehle, S. Grün, M. Diesmann, A. Aertsen, Spike synchronization and rate modulation differentially involved in motor cortical function, Science 278 (1997) 1950–1953]. Based on the unitary event (‘UE’) method, the authors have shown that excess coincidences between simultaneously recorded neurons occur dynamically at behaviorally relevant points in time. However, sensitivity of the UE method for non-stationarities and regularity of spike trains caused fear that the results presented might be, at least in part, false positives. We reanalyzed the same data with the new non-parametric method NeuroXidence, which is robust against firing-rate modulations, rate changes across trials, regularity or burstiness, as well as low rates. Our results based on NeuroXidence confirm the results presented in Riehle et al. [Spike synchronization and rate modulation differentially involved in motor cortical function, Science 278 (1997) 1950–1953] and demonstrate behaviorally modulated excesses of coincidences on a time scale of 3–5ms. [Copyright &y& Elsevier]
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  Data: <i>Copyright of Neurocomputing is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1016/j.neucom.2006.10.142
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      – Code: eng
        Text: English
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        StartPage: 2064
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        Type: general
      – SubjectFull: Frontal lobe
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      – SubjectFull: Action potentials
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      – SubjectFull: Electrophysiology
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      – SubjectFull: Computational neuroscience
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      – SubjectFull: Neurons
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      – TitleFull: Validation of task-related excess of spike coincidences based on NeuroXidence
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            – D: 01
              M: 06
              Text: Jun2007
              Type: published
              Y: 2007
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