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A New Mechanism for Benzopyrone Formation in Aromatic Polyketide Biosynthesis.

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Bibliographic Details
Title: A New Mechanism for Benzopyrone Formation in Aromatic Polyketide Biosynthesis.
Authors: Wenjun Zhang1, Wilke, Burkhardt I.2, Jixun Zhan1, Watanabe, Kenji3, Boddy, Christopher N.2 cnboddy@syr.edu, Yi Tang1 yitang@ucla.edu
Source: Journal of the American Chemical Society. 8/1/2007, Vol. 129 Issue 30, p9304-9305. 2p.
Subjects: Ketones, Catalysis, Aromatic compounds, Polyketides, Biosynthesis, Amides
Abstract: The article describes the expansion of the scope of non-enzyme-catalyzed modifications for benzopyrone formation in aromatic polyketide biosynthesis. According to the authors, a primary amide moiety can also serve as an electrophilic center when positioned favorably, readily yielding pyrone-containing polyketides. They add the involvement of the amide moiety in pyrone formation may be the mechanism by which pyrones are formed in other aromatic polyketides.
Database: Engineering Source
Description
Abstract:The article describes the expansion of the scope of non-enzyme-catalyzed modifications for benzopyrone formation in aromatic polyketide biosynthesis. According to the authors, a primary amide moiety can also serve as an electrophilic center when positioned favorably, readily yielding pyrone-containing polyketides. They add the involvement of the amide moiety in pyrone formation may be the mechanism by which pyrones are formed in other aromatic polyketides.
ISSN:00027863
DOI:10.1021/ja0736919