Intensity-Modulated Radiotherapy for Craniospinal Irradiation: Target Volume Considerations, Dose Constraints, and Competing Risks
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| Title: | Intensity-Modulated Radiotherapy for Craniospinal Irradiation: Target Volume Considerations, Dose Constraints, and Competing Risks |
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| Authors: | Parker, William1 william@medphys.mcgill.ca, Filion, Edith2, Roberge, David2, Freeman, Carolyn R.2 |
| Source: | International Journal of Radiation Oncology, Biology, Physics. Sep2007, Vol. 69 Issue 1, p251-257. 7p. |
| Subjects: | Radiotherapy, Medulloblastoma, Medical radiology, Cerebellar tumors |
| Abstract: | Purpose: To report the results of an analysis of dose received to tissues and organs outside the target volume, in the setting of spinal axis irradiation for the treatment of medulloblastoma, using three treatment techniques. Methods and Materials: Treatment plans (total dose, 23.4 Gy) for a standard two-dimensional (2D) technique, a three-dimensional (3D) technique using a 3D imaging-based target volume, and an intensity-modulated radiotherapy (IMRT) technique, were compared for 3 patients in terms of dose–volume statistics for target coverage, as well as organ at risk (OAR) and overall tissue sparing. Results: Planning target volume coverage and dose homogeneity was superior for the IMRT plans for V95% (IMRT, 100%; 3D, 96%; 2D, 98%) and V107% (IMRT, 3%; 3D, 38%; 2D, 37%). In terms of OAR sparing, the IMRT plan was better for all organs and whole-body contour when comparing V10Gy, V15Gy, and V20Gy. The 3D plan was superior for V5Gy and below. For the heart and liver in particular, the IMRT plans provided considerable sparing in terms of V10Gy and above. In terms of the integral dose, the IMRT plans were superior for liver (IMRT, 21.9 J; 3D, 28.6 J; 2D, 38.6 J) and heart (IMRT, 9 J; 3D, 14.1J; 2D, 19.4 J), the 3D plan for the body contour (IMRT, 349 J; 3D, 337 J; 2D, 555 J). Conclusions: Intensity-modulated radiotherapy is a valid treatment option for spinal axis irradiation. We have shown that IMRT results in sparing of organs at risk without a significant increase in integral dose. [Copyright &y& Elsevier] |
| Copyright of International Journal of Radiation Oncology, Biology, Physics is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 26248441 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Intensity-Modulated Radiotherapy for Craniospinal Irradiation: Target Volume Considerations, Dose Constraints, and Competing Risks – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Parker%2C+William%22">Parker, William</searchLink><relatesTo>1</relatesTo><i> william@medphys.mcgill.ca</i><br /><searchLink fieldCode="AR" term="%22Filion%2C+Edith%22">Filion, Edith</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Roberge%2C+David%22">Roberge, David</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Freeman%2C+Carolyn+R%2E%22">Freeman, Carolyn R.</searchLink><relatesTo>2</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Radiation+Oncology%2C+Biology%2C+Physics%22">International Journal of Radiation Oncology, Biology, Physics</searchLink>. Sep2007, Vol. 69 Issue 1, p251-257. 7p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Radiotherapy%22">Radiotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22Medulloblastoma%22">Medulloblastoma</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+radiology%22">Medical radiology</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebellar+tumors%22">Cerebellar tumors</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Purpose: To report the results of an analysis of dose received to tissues and organs outside the target volume, in the setting of spinal axis irradiation for the treatment of medulloblastoma, using three treatment techniques. Methods and Materials: Treatment plans (total dose, 23.4 Gy) for a standard two-dimensional (2D) technique, a three-dimensional (3D) technique using a 3D imaging-based target volume, and an intensity-modulated radiotherapy (IMRT) technique, were compared for 3 patients in terms of dose–volume statistics for target coverage, as well as organ at risk (OAR) and overall tissue sparing. Results: Planning target volume coverage and dose homogeneity was superior for the IMRT plans for V95% (IMRT, 100%; 3D, 96%; 2D, 98%) and V107% (IMRT, 3%; 3D, 38%; 2D, 37%). In terms of OAR sparing, the IMRT plan was better for all organs and whole-body contour when comparing V10Gy, V15Gy, and V20Gy. The 3D plan was superior for V5Gy and below. For the heart and liver in particular, the IMRT plans provided considerable sparing in terms of V10Gy and above. In terms of the integral dose, the IMRT plans were superior for liver (IMRT, 21.9 J; 3D, 28.6 J; 2D, 38.6 J) and heart (IMRT, 9 J; 3D, 14.1J; 2D, 19.4 J), the 3D plan for the body contour (IMRT, 349 J; 3D, 337 J; 2D, 555 J). Conclusions: Intensity-modulated radiotherapy is a valid treatment option for spinal axis irradiation. We have shown that IMRT results in sparing of organs at risk without a significant increase in integral dose. [Copyright &y& Elsevier] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of International Journal of Radiation Oncology, Biology, Physics is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.ijrobp.2007.04.052 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 7 StartPage: 251 Subjects: – SubjectFull: Radiotherapy Type: general – SubjectFull: Medulloblastoma Type: general – SubjectFull: Medical radiology Type: general – SubjectFull: Cerebellar tumors Type: general Titles: – TitleFull: Intensity-Modulated Radiotherapy for Craniospinal Irradiation: Target Volume Considerations, Dose Constraints, and Competing Risks Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Parker, William – PersonEntity: Name: NameFull: Filion, Edith – PersonEntity: Name: NameFull: Roberge, David – PersonEntity: Name: NameFull: Freeman, Carolyn R. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Text: Sep2007 Type: published Y: 2007 Identifiers: – Type: issn-print Value: 03603016 Numbering: – Type: volume Value: 69 – Type: issue Value: 1 Titles: – TitleFull: International Journal of Radiation Oncology, Biology, Physics Type: main |
| ResultId | 1 |
