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Chronic Inflammatory Autoimmune Disorders and Atherosclerosis.

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Title: Chronic Inflammatory Autoimmune Disorders and Atherosclerosis.
Authors: ABOU‐RAYA, S.1 (AUTHOR), ABOU‐RAYA, A.2 (AUTHOR), NAIM, A.3 (AUTHOR), ABUELKHEIR, H.4 (AUTHOR)
Source: Annals of the New York Academy of Sciences. 2007, Vol. 1107, p56-67. 12p. 1 Diagram, 1 Chart.
Subjects: Autoimmune diseases, Atherosclerosis, Rheumatoid arthritis, Periodontal disease, Coronary disease, Inflammation, Vascular diseases, Cardiovascular diseases, Medical research
Abstract: Rheumatoid arthritis (RA), periodontal disease (PD), and coronary artery disease (CAD) are common chronic inflammatory diseases. RA is associated with accelerated vascular risk resulting in an increased prevalence of CAD with attendant early mortality and excess morbidity. RA and PD have a common pathobiology. Accordingly, the aim of this study was to evaluate the association between RA, PD, and CAD and the influence of systemic inflammatory factors. A total of 100 active RA patients of which 50 had established CAD and 50 had no CAD were assessed for PD. All subjects underwent a clinical, cardiac, dental, laboratory, and radiological evaluation. Blood samples were obtained and the level of high-sensitivity C-reactive protein (hs-CRP), total white blood counts (WBC), erythrocyte sedimentation rate (ESR), fibrinogen and tumor necrosis alpha (TNF-α), total cholesterol (TC), and high-density lipoprotein (HDL) were assayed. The findings of this study demonstrated an association between RA, PD, and CAD. The RA patients with CAD had significantly more PD than RA patients without CAD, P < 0.001. The inflammatory markers hs-CRP, ESR, WBC, fibrinogen, and TNF-α were raised in all patients but were significantly higher in RA patients with CAD who also had PD, that is, in those with more inflammatory disease burden. HDL levels were lower in RA patients with CAD when compared to RA patients without CAD, P < 0.005. Evidence from this study shows an association between RA, PD, CAD, and systemic levels of the inflammatory mediators. The implication is that inflammation may be the central link between the chronic inflammatory autoimmune disorders and atherosclerosis. [ABSTRACT FROM AUTHOR]
Copyright of Annals of the New York Academy of Sciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Chronic Inflammatory Autoimmune Disorders and Atherosclerosis.
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  Data: Rheumatoid arthritis (RA), periodontal disease (PD), and coronary artery disease (CAD) are common chronic inflammatory diseases. RA is associated with accelerated vascular risk resulting in an increased prevalence of CAD with attendant early mortality and excess morbidity. RA and PD have a common pathobiology. Accordingly, the aim of this study was to evaluate the association between RA, PD, and CAD and the influence of systemic inflammatory factors. A total of 100 active RA patients of which 50 had established CAD and 50 had no CAD were assessed for PD. All subjects underwent a clinical, cardiac, dental, laboratory, and radiological evaluation. Blood samples were obtained and the level of high-sensitivity C-reactive protein (hs-CRP), total white blood counts (WBC), erythrocyte sedimentation rate (ESR), fibrinogen and tumor necrosis alpha (TNF-α), total cholesterol (TC), and high-density lipoprotein (HDL) were assayed. The findings of this study demonstrated an association between RA, PD, and CAD. The RA patients with CAD had significantly more PD than RA patients without CAD, P &lt; 0.001. The inflammatory markers hs-CRP, ESR, WBC, fibrinogen, and TNF-α were raised in all patients but were significantly higher in RA patients with CAD who also had PD, that is, in those with more inflammatory disease burden. HDL levels were lower in RA patients with CAD when compared to RA patients without CAD, P &lt; 0.005. Evidence from this study shows an association between RA, PD, CAD, and systemic levels of the inflammatory mediators. The implication is that inflammation may be the central link between the chronic inflammatory autoimmune disorders and atherosclerosis. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Annals of the New York Academy of Sciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1196/annals.1381.007
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 12
        StartPage: 56
    Subjects:
      – SubjectFull: Autoimmune diseases
        Type: general
      – SubjectFull: Atherosclerosis
        Type: general
      – SubjectFull: Rheumatoid arthritis
        Type: general
      – SubjectFull: Periodontal disease
        Type: general
      – SubjectFull: Coronary disease
        Type: general
      – SubjectFull: Inflammation
        Type: general
      – SubjectFull: Vascular diseases
        Type: general
      – SubjectFull: Cardiovascular diseases
        Type: general
      – SubjectFull: Medical research
        Type: general
    Titles:
      – TitleFull: Chronic Inflammatory Autoimmune Disorders and Atherosclerosis.
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            NameFull: NAIM, A.
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              M: 07
              Text: 2007
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              Y: 2007
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