View in EDS

Is a 3-mm intrafractional margin sufficient for daily image-guided intensity-modulated radiation therapy of prostate cancer?

Saved in:
Bibliographic Details
Title: Is a 3-mm intrafractional margin sufficient for daily image-guided intensity-modulated radiation therapy of prostate cancer?
Authors: Melancon, Adam D.1,2, O’Daniel, Jennifer C.1, Zhang, Lifei1, Kudchadker, Rajat J.1, Kuban, Deborah A.3, Lee, Andrew K.3, Cheung, Rex M.3, de Crevoisier, Renaud3, Tucker, Susan L.4, Newhauser, Wayne D.1, Mohan, Radhe1, Dong, Lei1 ldong@mdanderson.org
Source: Radiotherapy & Oncology. Nov2007, Vol. 85 Issue 2, p251-259. 9p.
Subjects: Cancer treatment, Prostate cancer, Male reproductive organs, Medical radiography
Abstract: Abstract: Purpose: To determine whether a 3-mm isotropic target margin adequately covers the prostate and seminal vesicles (SVs) during administration of an intensity-modulated radiation therapy (IMRT) treatment fraction, assuming that daily image-guided setup is performed just before each fraction. Materials and methods: In-room computed tomographic (CT) scans were acquired immediately before and after a daily treatment fraction in 46 patients with prostate cancer. An eight-field IMRT plan was designed using the pre-fraction CT with a 3-mm margin and subsequently recalculated on the post-fraction CT. For convenience of comparison, dose plans were scaled to full course of treatment (75.6Gy). Dose coverage was assessed on the post-treatment CT image set. Results: During one treatment fraction (21.4±5.5min), there were reductions in the volumes of the prostate and SVs receiving the prescribed dose (median reduction 0.1% and 1.0%, respectively, p <0.001) and in the minimum dose to 0.1 cm3 of their volumes (median reduction 0.5 and 1.5Gy, p <0.001). Of the 46 patients, three patients’ prostates and eight patients’ SVs did not maintain dose coverage above 70Gy. Rectal filling correlated with decreased percentage-volume of SV receiving 75.6, 70, and 60Gy (p <0.02). Conclusions: The 3-mm intrafractional margin was adequate for prostate dose coverage. However, a significant subset of patients lost SV dose coverage. The rectal volume change significantly affected SV dose coverage. For advanced-stage prostate cancers, we recommend to use larger margins or improve organ immobilization (such as with a rectal balloon) to ensure SV coverage. [Copyright &y& Elsevier]
Copyright of Radiotherapy & Oncology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
FullText Text:
  Availability: 0
Header DbId: egs
DbLabel: Engineering Source
An: 27742115
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Is a 3-mm intrafractional margin sufficient for daily image-guided intensity-modulated radiation therapy of prostate cancer?
– Name: Author
  Label: Authors
  Group: Au
  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Melancon%2C+Adam+D%2E%22&quot;&gt;Melancon, Adam D.&lt;/searchLink&gt;&lt;relatesTo&gt;1,2&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22O’Daniel%2C+Jennifer+C%2E%22&quot;&gt;O’Daniel, Jennifer C.&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Zhang%2C+Lifei%22&quot;&gt;Zhang, Lifei&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Kudchadker%2C+Rajat+J%2E%22&quot;&gt;Kudchadker, Rajat J.&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Kuban%2C+Deborah+A%2E%22&quot;&gt;Kuban, Deborah A.&lt;/searchLink&gt;&lt;relatesTo&gt;3&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Lee%2C+Andrew+K%2E%22&quot;&gt;Lee, Andrew K.&lt;/searchLink&gt;&lt;relatesTo&gt;3&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Cheung%2C+Rex+M%2E%22&quot;&gt;Cheung, Rex M.&lt;/searchLink&gt;&lt;relatesTo&gt;3&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22de+Crevoisier%2C+Renaud%22&quot;&gt;de Crevoisier, Renaud&lt;/searchLink&gt;&lt;relatesTo&gt;3&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Tucker%2C+Susan+L%2E%22&quot;&gt;Tucker, Susan L.&lt;/searchLink&gt;&lt;relatesTo&gt;4&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Newhauser%2C+Wayne+D%2E%22&quot;&gt;Newhauser, Wayne D.&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Mohan%2C+Radhe%22&quot;&gt;Mohan, Radhe&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Dong%2C+Lei%22&quot;&gt;Dong, Lei&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;i&gt; ldong@mdanderson.org&lt;/i&gt;
– Name: TitleSource
  Label: Source
  Group: Src
  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Radiotherapy+%26+Oncology%22&quot;&gt;Radiotherapy &amp; Oncology&lt;/searchLink&gt;. Nov2007, Vol. 85 Issue 2, p251-259. 9p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Cancer+treatment%22&quot;&gt;Cancer treatment&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Prostate+cancer%22&quot;&gt;Prostate cancer&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Male+reproductive+organs%22&quot;&gt;Male reproductive organs&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Medical+radiography%22&quot;&gt;Medical radiography&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Abstract: Purpose: To determine whether a 3-mm isotropic target margin adequately covers the prostate and seminal vesicles (SVs) during administration of an intensity-modulated radiation therapy (IMRT) treatment fraction, assuming that daily image-guided setup is performed just before each fraction. Materials and methods: In-room computed tomographic (CT) scans were acquired immediately before and after a daily treatment fraction in 46 patients with prostate cancer. An eight-field IMRT plan was designed using the pre-fraction CT with a 3-mm margin and subsequently recalculated on the post-fraction CT. For convenience of comparison, dose plans were scaled to full course of treatment (75.6Gy). Dose coverage was assessed on the post-treatment CT image set. Results: During one treatment fraction (21.4&#177;5.5min), there were reductions in the volumes of the prostate and SVs receiving the prescribed dose (median reduction 0.1% and 1.0%, respectively, p &lt;0.001) and in the minimum dose to 0.1 cm3 of their volumes (median reduction 0.5 and 1.5Gy, p &lt;0.001). Of the 46 patients, three patients’ prostates and eight patients’ SVs did not maintain dose coverage above 70Gy. Rectal filling correlated with decreased percentage-volume of SV receiving 75.6, 70, and 60Gy (p &lt;0.02). Conclusions: The 3-mm intrafractional margin was adequate for prostate dose coverage. However, a significant subset of patients lost SV dose coverage. The rectal volume change significantly affected SV dose coverage. For advanced-stage prostate cancers, we recommend to use larger margins or improve organ immobilization (such as with a rectal balloon) to ensure SV coverage. [Copyright &amp;y&amp; Elsevier]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: &lt;i&gt;Copyright of Radiotherapy &amp; Oncology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=27742115
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.radonc.2007.08.008
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 9
        StartPage: 251
    Subjects:
      – SubjectFull: Cancer treatment
        Type: general
      – SubjectFull: Prostate cancer
        Type: general
      – SubjectFull: Male reproductive organs
        Type: general
      – SubjectFull: Medical radiography
        Type: general
    Titles:
      – TitleFull: Is a 3-mm intrafractional margin sufficient for daily image-guided intensity-modulated radiation therapy of prostate cancer?
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Melancon, Adam D.
      – PersonEntity:
          Name:
            NameFull: O’Daniel, Jennifer C.
      – PersonEntity:
          Name:
            NameFull: Zhang, Lifei
      – PersonEntity:
          Name:
            NameFull: Kudchadker, Rajat J.
      – PersonEntity:
          Name:
            NameFull: Kuban, Deborah A.
      – PersonEntity:
          Name:
            NameFull: Lee, Andrew K.
      – PersonEntity:
          Name:
            NameFull: Cheung, Rex M.
      – PersonEntity:
          Name:
            NameFull: de Crevoisier, Renaud
      – PersonEntity:
          Name:
            NameFull: Tucker, Susan L.
      – PersonEntity:
          Name:
            NameFull: Newhauser, Wayne D.
      – PersonEntity:
          Name:
            NameFull: Mohan, Radhe
      – PersonEntity:
          Name:
            NameFull: Dong, Lei
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 11
              Text: Nov2007
              Type: published
              Y: 2007
          Identifiers:
            – Type: issn-print
              Value: 01678140
          Numbering:
            – Type: volume
              Value: 85
            – Type: issue
              Value: 2
          Titles:
            – TitleFull: Radiotherapy & Oncology
              Type: main
ResultId 1