Effects of Zinc Supplementation on Clinical Outcomes in Patients Receiving Radiotherapy for Head and Neck Cancers: A Double-Blinded Randomized Study
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| Title: | Effects of Zinc Supplementation on Clinical Outcomes in Patients Receiving Radiotherapy for Head and Neck Cancers: A Double-Blinded Randomized Study |
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| Authors: | Lin, Li-Ching1 8508A6@mail.chimei.org.tw, Que, Jenny1, Lin, Kuei-Li1, Leung, Henry Wing-Cheung1, Lu, Chin-Li2, Chang, Ching-Hsiung3 |
| Source: | International Journal of Radiation Oncology, Biology, Physics. Feb2008, Vol. 70 Issue 2, p368-373. 6p. |
| Subjects: | Head & neck cancer, Cancer radiotherapy, Randomized controlled trials, Zinc |
| Abstract: | Purpose: To evaluate the impact of zinc supplementation on the survival of patients after receiving radiotherapy for head and neck cancers. Methods and Materials: Patients were randomly divided into two groups; experimental and control. Patients in the experimental group received a predetermined dose of a zinc supplement, and the control group, a placebo. The 50 patients in each group could be considered homogenous with respect to medical histories, tumor characteristics, and therapeutic details. Results: Patients in both groups appeared to have similar results for 3-year overall, disease-free, and metastases-free survival rates (p = 0.19, p = 0.54, and p = 0.35, respectively). However, patients in the experimental group had better 3-year local-free survival (LFS), although the difference was only marginal (p = 0.092). Another difference was that patients in the experimental group with Stages III–IV disease had a much better 3-year LFS rate when they received concurrent chemoradiotherapy (p = 0.003). Conclusions: One impact seen was that zinc supplementation improved LFS at 3 years after beginning treatment for patients with Stages III–IV disease. It is imperative that these patients be followed up for a longer period to draw a definite conclusion. [Copyright &y& Elsevier] |
| Copyright of International Journal of Radiation Oncology, Biology, Physics is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 28610367 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Effects of Zinc Supplementation on Clinical Outcomes in Patients Receiving Radiotherapy for Head and Neck Cancers: A Double-Blinded Randomized Study – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Lin%2C+Li-Ching%22">Lin, Li-Ching</searchLink><relatesTo>1</relatesTo><i> 8508A6@mail.chimei.org.tw</i><br /><searchLink fieldCode="AR" term="%22Que%2C+Jenny%22">Que, Jenny</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Lin%2C+Kuei-Li%22">Lin, Kuei-Li</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Leung%2C+Henry+Wing-Cheung%22">Leung, Henry Wing-Cheung</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Lu%2C+Chin-Li%22">Lu, Chin-Li</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Chang%2C+Ching-Hsiung%22">Chang, Ching-Hsiung</searchLink><relatesTo>3</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Radiation+Oncology%2C+Biology%2C+Physics%22">International Journal of Radiation Oncology, Biology, Physics</searchLink>. Feb2008, Vol. 70 Issue 2, p368-373. 6p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Head+%26+neck+cancer%22">Head & neck cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+radiotherapy%22">Cancer radiotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22Randomized+controlled+trials%22">Randomized controlled trials</searchLink><br /><searchLink fieldCode="DE" term="%22Zinc%22">Zinc</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Purpose: To evaluate the impact of zinc supplementation on the survival of patients after receiving radiotherapy for head and neck cancers. Methods and Materials: Patients were randomly divided into two groups; experimental and control. Patients in the experimental group received a predetermined dose of a zinc supplement, and the control group, a placebo. The 50 patients in each group could be considered homogenous with respect to medical histories, tumor characteristics, and therapeutic details. Results: Patients in both groups appeared to have similar results for 3-year overall, disease-free, and metastases-free survival rates (p = 0.19, p = 0.54, and p = 0.35, respectively). However, patients in the experimental group had better 3-year local-free survival (LFS), although the difference was only marginal (p = 0.092). Another difference was that patients in the experimental group with Stages III–IV disease had a much better 3-year LFS rate when they received concurrent chemoradiotherapy (p = 0.003). Conclusions: One impact seen was that zinc supplementation improved LFS at 3 years after beginning treatment for patients with Stages III–IV disease. It is imperative that these patients be followed up for a longer period to draw a definite conclusion. [Copyright &y& Elsevier] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of International Journal of Radiation Oncology, Biology, Physics is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.ijrobp.2007.06.073 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 6 StartPage: 368 Subjects: – SubjectFull: Head & neck cancer Type: general – SubjectFull: Cancer radiotherapy Type: general – SubjectFull: Randomized controlled trials Type: general – SubjectFull: Zinc Type: general Titles: – TitleFull: Effects of Zinc Supplementation on Clinical Outcomes in Patients Receiving Radiotherapy for Head and Neck Cancers: A Double-Blinded Randomized Study Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Lin, Li-Ching – PersonEntity: Name: NameFull: Que, Jenny – PersonEntity: Name: NameFull: Lin, Kuei-Li – PersonEntity: Name: NameFull: Leung, Henry Wing-Cheung – PersonEntity: Name: NameFull: Lu, Chin-Li – PersonEntity: Name: NameFull: Chang, Ching-Hsiung IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 02 Text: Feb2008 Type: published Y: 2008 Identifiers: – Type: issn-print Value: 03603016 Numbering: – Type: volume Value: 70 – Type: issue Value: 2 Titles: – TitleFull: International Journal of Radiation Oncology, Biology, Physics Type: main |
| ResultId | 1 |
