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Biotechnological applications of brown spider (Loxosceles genus) venom toxins

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Title: Biotechnological applications of brown spider (Loxosceles genus) venom toxins
Authors: Senff-Ribeiro, Andrea1, Henrique da Silva, Paulo1, Chaim, Olga Meiri1,2, Gremski, Luiza Helena1,2, Paludo, Kátia Sabrina3, Bertoni da Silveira, Rafael1,4, Gremski, Waldemiro1, Mangili, Oldemir Carlos5, Veiga, Silvio Sanches1 veigass@ufpr.br
Source: Biotechnology Advances. May2008, Vol. 26 Issue 3, p210-218. 9p.
Subjects: Loxoscelidae, Toxins, Venom, Molecular biology
Abstract: Abstract: Loxoscelism (the term used to define accidents by the bite of brown spiders) has been reported worldwide. Clinical manifestations following brown spider bites are frequently associated with skin degeneration, a massive inflammatory response at the injured region, intravascular hemolysis, platelet aggregation causing thrombocytopenia and renal disturbances. The mechanisms by which the venom exerts its noxious effects are currently under investigation. The whole venom is a complex mixture of toxins enriched with low molecular mass proteins in the range of 5–40 kDa. Toxins including alkaline phosphatase, hyaluronidase, metalloproteases (astacin-like proteases), low molecular mass (5.6–7.9 kDa) insecticidal peptides and phospholipases-D (dermonecrotic toxins) have been identified in the venom. The purpose of the present review is to describe biotechnological applications of whole venom or some toxins, with especial emphasis upon molecular biology findings obtained in the last years. [Copyright &y& Elsevier]
Copyright of Biotechnology Advances is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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  Availability: 0
Header DbId: egs
DbLabel: Engineering Source
An: 31559820
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Biotechnological applications of brown spider (Loxosceles genus) venom toxins
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  Data: <searchLink fieldCode="AR" term="%22Senff-Ribeiro%2C+Andrea%22">Senff-Ribeiro, Andrea</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Henrique+da+Silva%2C+Paulo%22">Henrique da Silva, Paulo</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Chaim%2C+Olga+Meiri%22">Chaim, Olga Meiri</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Gremski%2C+Luiza+Helena%22">Gremski, Luiza Helena</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Paludo%2C+Kátia+Sabrina%22">Paludo, Kátia Sabrina</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Bertoni+da+Silveira%2C+Rafael%22">Bertoni da Silveira, Rafael</searchLink><relatesTo>1,4</relatesTo><br /><searchLink fieldCode="AR" term="%22Gremski%2C+Waldemiro%22">Gremski, Waldemiro</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Mangili%2C+Oldemir+Carlos%22">Mangili, Oldemir Carlos</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Veiga%2C+Silvio+Sanches%22">Veiga, Silvio Sanches</searchLink><relatesTo>1</relatesTo><i> veigass@ufpr.br</i>
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  Data: <searchLink fieldCode="JN" term="%22Biotechnology+Advances%22">Biotechnology Advances</searchLink>. May2008, Vol. 26 Issue 3, p210-218. 9p.
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  Data: Abstract: Loxoscelism (the term used to define accidents by the bite of brown spiders) has been reported worldwide. Clinical manifestations following brown spider bites are frequently associated with skin degeneration, a massive inflammatory response at the injured region, intravascular hemolysis, platelet aggregation causing thrombocytopenia and renal disturbances. The mechanisms by which the venom exerts its noxious effects are currently under investigation. The whole venom is a complex mixture of toxins enriched with low molecular mass proteins in the range of 5–40 kDa. Toxins including alkaline phosphatase, hyaluronidase, metalloproteases (astacin-like proteases), low molecular mass (5.6–7.9 kDa) insecticidal peptides and phospholipases-D (dermonecrotic toxins) have been identified in the venom. The purpose of the present review is to describe biotechnological applications of whole venom or some toxins, with especial emphasis upon molecular biology findings obtained in the last years. [Copyright &y& Elsevier]
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  Data: <i>Copyright of Biotechnology Advances is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=31559820
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              Text: May2008
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