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Mining logic gates in prokaryotic transcriptional regulation networks

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Title: Mining logic gates in prokaryotic transcriptional regulation networks
Authors: Silva-Rocha, Rafael1, de Lorenzo, Víctor vdlorenzo@cnb.csic.es
Source: FEBS Letters. Apr2008, Vol. 582 Issue 8, p1237-1244. 8p.
Subjects: Prokaryotes, Microorganisms, Boolean algebra, Electric circuits
Abstract: Abstract: Prokaryotic transcriptional networks possess a large number of regulatory modules that formally implement many of the logic gates that are typical of digital, Boolean circuits. Yet, natural regulatory elements appear most often compressed and exaggeratedly context-dependent for any reliable circuit engineering barely comparable to electronic counterparts. To overcome this impasse, we argue that designing new functions with biological parts requires (i) the recognition of logic gates not yet assigned but surely present in the meta-genome, (ii) the orthogonalization and disambiguation of natural regulatory modules and (iii) the development of ways to tackle the connectivity and the definition of boundaries between minimal biological components. [Copyright &y& Elsevier]
Copyright of FEBS Letters is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
An: 31561479
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Mining logic gates in prokaryotic transcriptional regulation networks
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  Data: <searchLink fieldCode="AR" term="%22Silva-Rocha%2C+Rafael%22">Silva-Rocha, Rafael</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22de+Lorenzo%2C+Víctor%22">de Lorenzo, Víctor</searchLink><i> vdlorenzo@cnb.csic.es</i>
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  Data: <searchLink fieldCode="JN" term="%22FEBS+Letters%22">FEBS Letters</searchLink>. Apr2008, Vol. 582 Issue 8, p1237-1244. 8p.
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  Data: Abstract: Prokaryotic transcriptional networks possess a large number of regulatory modules that formally implement many of the logic gates that are typical of digital, Boolean circuits. Yet, natural regulatory elements appear most often compressed and exaggeratedly context-dependent for any reliable circuit engineering barely comparable to electronic counterparts. To overcome this impasse, we argue that designing new functions with biological parts requires (i) the recognition of logic gates not yet assigned but surely present in the meta-genome, (ii) the orthogonalization and disambiguation of natural regulatory modules and (iii) the development of ways to tackle the connectivity and the definition of boundaries between minimal biological components. [Copyright &y& Elsevier]
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  Data: <i>Copyright of FEBS Letters is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1016/j.febslet.2008.01.060
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      – Code: eng
        Text: English
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      – SubjectFull: Boolean algebra
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      – TitleFull: Mining logic gates in prokaryotic transcriptional regulation networks
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            NameFull: Silva-Rocha, Rafael
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              Text: Apr2008
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              Y: 2008
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