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Sensitive Terbium Probes for Luminescent Determination of both Alkaline Phosphatase and Codeine Phosphate.

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Title: Sensitive Terbium Probes for Luminescent Determination of both Alkaline Phosphatase and Codeine Phosphate.
Authors: Duerkop, Axel1 (AUTHOR), Aleksandrova, Darya2 (AUTHOR), Scripinets, Yuliya2 (AUTHOR), Yegorova, Alla1,2 (AUTHOR), Vityukova, Ekateryna2 (AUTHOR)
Source: Annals of the New York Academy of Sciences. May2008, Vol. 1130, p172-178. 7p. 1 Diagram, 4 Charts, 1 Graph.
Subjects: Semiconductor analysis, Alkaline phosphatase, Carbonyl compounds, Ligands (Biochemistry), Electronic excitation, Metal quenching, Metal ions, Spectrum analysis, Scientific method
Abstract: New terbium complexes of 2-oxo-4-hydroxy-quinoline-3-carboxylic acid derivatives are reported for determination of alkaline phosphatase (aPase) and codeine phosphate (CP). Complexation with terbium occurs by way of the oxygen atoms of the 4-hydroxyl group and the carbonyl group of the 3-carboxy function, respectively. The complexes are highly luminescent and do not require luminescence enhancers. The excitation maxima of the terbium chelates are at 320 nm. The assay is based on the quenching of the hypersensitive 545-nm luminescence of the terbium complexes with the ligands 4-hydroxy-1-methyl-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid (5-ethyl-[1,3,4]thiadiazol-2-yl)-amide (L1) and 1-ethyl-4-hydroxy-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid (4-trifluoromethyl-phenyl)-amide (L2) by phosphate ions. The assays require equimolar (1.0 μM) concentrations of Tb3+ and of the ligand at pH 8.0 (Tris–HCl buffer). The luminescence quenching is proportional to the concentration of aPase and CP within the range of 0.1–70 mU mL−1 and 0.3–20 μg mL−1, respectively. The detection limits were 0.05 mU mL−1 = 40.0 pmol L−1 of aPase and 0.120 μg mL−1 of CP. [ABSTRACT FROM AUTHOR]
Copyright of Annals of the New York Academy of Sciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Label: Title
  Group: Ti
  Data: Sensitive Terbium Probes for Luminescent Determination of both Alkaline Phosphatase and Codeine Phosphate.
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  Label: Authors
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  Data: <searchLink fieldCode="AR" term="%22Duerkop%2C+Axel%22">Duerkop, Axel</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Aleksandrova%2C+Darya%22">Aleksandrova, Darya</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Scripinets%2C+Yuliya%22">Scripinets, Yuliya</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yegorova%2C+Alla%22">Yegorova, Alla</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vityukova%2C+Ekateryna%22">Vityukova, Ekateryna</searchLink><relatesTo>2</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Annals+of+the+New+York+Academy+of+Sciences%22">Annals of the New York Academy of Sciences</searchLink>. May2008, Vol. 1130, p172-178. 7p. 1 Diagram, 4 Charts, 1 Graph.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Semiconductor+analysis%22">Semiconductor analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Alkaline+phosphatase%22">Alkaline phosphatase</searchLink><br /><searchLink fieldCode="DE" term="%22Carbonyl+compounds%22">Carbonyl compounds</searchLink><br /><searchLink fieldCode="DE" term="%22Ligands+%28Biochemistry%29%22">Ligands (Biochemistry)</searchLink><br /><searchLink fieldCode="DE" term="%22Electronic+excitation%22">Electronic excitation</searchLink><br /><searchLink fieldCode="DE" term="%22Metal+quenching%22">Metal quenching</searchLink><br /><searchLink fieldCode="DE" term="%22Metal+ions%22">Metal ions</searchLink><br /><searchLink fieldCode="DE" term="%22Spectrum+analysis%22">Spectrum analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Scientific+method%22">Scientific method</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: New terbium complexes of 2-oxo-4-hydroxy-quinoline-3-carboxylic acid derivatives are reported for determination of alkaline phosphatase (aPase) and codeine phosphate (CP). Complexation with terbium occurs by way of the oxygen atoms of the 4-hydroxyl group and the carbonyl group of the 3-carboxy function, respectively. The complexes are highly luminescent and do not require luminescence enhancers. The excitation maxima of the terbium chelates are at 320 nm. The assay is based on the quenching of the hypersensitive 545-nm luminescence of the terbium complexes with the ligands 4-hydroxy-1-methyl-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid (5-ethyl-[1,3,4]thiadiazol-2-yl)-amide (L1) and 1-ethyl-4-hydroxy-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid (4-trifluoromethyl-phenyl)-amide (L2) by phosphate ions. The assays require equimolar (1.0 μM) concentrations of Tb3+ and of the ligand at pH 8.0 (Tris–HCl buffer). The luminescence quenching is proportional to the concentration of aPase and CP within the range of 0.1–70 mU mL−1 and 0.3–20 μg mL−1, respectively. The detection limits were 0.05 mU mL−1 = 40.0 pmol L−1 of aPase and 0.120 μg mL−1 of CP. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Annals of the New York Academy of Sciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1196/annals.1430.019
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 7
        StartPage: 172
    Subjects:
      – SubjectFull: Semiconductor analysis
        Type: general
      – SubjectFull: Alkaline phosphatase
        Type: general
      – SubjectFull: Carbonyl compounds
        Type: general
      – SubjectFull: Ligands (Biochemistry)
        Type: general
      – SubjectFull: Electronic excitation
        Type: general
      – SubjectFull: Metal quenching
        Type: general
      – SubjectFull: Metal ions
        Type: general
      – SubjectFull: Spectrum analysis
        Type: general
      – SubjectFull: Scientific method
        Type: general
    Titles:
      – TitleFull: Sensitive Terbium Probes for Luminescent Determination of both Alkaline Phosphatase and Codeine Phosphate.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Duerkop, Axel
      – PersonEntity:
          Name:
            NameFull: Aleksandrova, Darya
      – PersonEntity:
          Name:
            NameFull: Scripinets, Yuliya
      – PersonEntity:
          Name:
            NameFull: Yegorova, Alla
      – PersonEntity:
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            NameFull: Vityukova, Ekateryna
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          Dates:
            – D: 03
              M: 05
              Text: May2008
              Type: published
              Y: 2008
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              Value: 00778923
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            – Type: volume
              Value: 1130
          Titles:
            – TitleFull: Annals of the New York Academy of Sciences
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