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A Strategy for the Solution-Phase Parallel Synthesis of N-(Pyrrolidinylmethyl)hydroxamic Acids.

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Bibliographic Details
Title:	A Strategy for the Solution-Phase Parallel Synthesis of N-(Pyrrolidinylmethyl)hydroxamic Acids.
Authors:	Takayanagi, Masaru, Flessner, Timo
Source:	Journal of Organic Chemistry. 06/16/2000, Vol. 65 Issue 12, p3811. 5p. 3 Diagrams, 1 Chart.
Subjects:	Imino compounds, Cyclitols, Hydroxamic acids, Manganese, Biosynthesis
Abstract:	Describes the development of a general strategy toward the parallel synthesis of a five-membered iminocyclitol linked to a hydroxamic acid group designed to mimic the transition state of GDP-fucose complexed with Mn(II) in fucosyltransferase reactions. Preparation of an iminocyclitol containing a protected hydroxylamine unit from D-mannitol.
Database:	Engineering Source

Description
Abstract:	Describes the development of a general strategy toward the parallel synthesis of a five-membered iminocyclitol linked to a hydroxamic acid group designed to mimic the transition state of GDP-fucose complexed with Mn(II) in fucosyltransferase reactions. Preparation of an iminocyclitol containing a protected hydroxylamine unit from D-mannitol.
ISSN:	00223263
DOI:	10.1021/jo000186k