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Postmortem biochemistry and immunohistochemistry of adrenocorticotropic hormone with special regard to fatal hypothermia

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Title: Postmortem biochemistry and immunohistochemistry of adrenocorticotropic hormone with special regard to fatal hypothermia
Authors: Ishikawa, Takaki1 takaki@med.osaka-cu.ac.jp, Quan, Li1, Li, Dong-Ri1, Zhao, Dong1, Michiue, Tomomi1, Hamel, Marianne2, Maeda, Hitoshi1
Source: Forensic Science International. Aug2008, Vol. 179 Issue 2/3, p147-151. 5p.
Subjects: Forensic pathologists, Adrenocorticotropic hormone, Immunohistochemistry, Hypothermia, Training
Abstract: Abstract: Adrenocorticotropic hormone (ACTH) is involved in systemic reactions to stress. The aim of the present study was a comprehensive analysis of serum and cerebrospinal fluid (CSF) levels of ACTH, and the pituitary immunohistochemistry with special regard to fatal hypothermia in routine forensic autopsy cases (n =162: 5–97 years of age; 114 males and 48 females; 4h to 3 days postmortem, median, 19.2h). The ACTH concentrations were independent of the postmortem time, gender, or age of the subjects. The serum ACTH level was similar to the clinical reference value for sharp instrument injury, fire fatality, and hypothermia, but was lower in other groups including hyperthermia, in particular for asphyxia and poisoning. The CSF level was usually much higher than the serum level, but was significantly lower for hypothermia and hyperthermia than in other groups (p <0.01). The rate of ACTH-immunopositivity in the anterior pituitary was low in cases of fatal hypothermia and hyperthermia, while it was high in cases of blunt injury, fire fatality, and acute ischemic heart disease. These observations showed that ACTH levels in the serum and CSF depended on the cause of death. The serum level was maintained despite a low CSF level and pituitary immunopositivity for fatal hypothermia, while the serum and CSF levels as well as pituitary immunopositivity were decreased for hyperthermia. [Copyright &y& Elsevier]
Copyright of Forensic Science International is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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DbLabel: Engineering Source
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  Data: Postmortem biochemistry and immunohistochemistry of adrenocorticotropic hormone with special regard to fatal hypothermia
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ishikawa%2C+Takaki%22&quot;&gt;Ishikawa, Takaki&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;i&gt; takaki@med.osaka-cu.ac.jp&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Quan%2C+Li%22&quot;&gt;Quan, Li&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Li%2C+Dong-Ri%22&quot;&gt;Li, Dong-Ri&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Zhao%2C+Dong%22&quot;&gt;Zhao, Dong&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Michiue%2C+Tomomi%22&quot;&gt;Michiue, Tomomi&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Hamel%2C+Marianne%22&quot;&gt;Hamel, Marianne&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Maeda%2C+Hitoshi%22&quot;&gt;Maeda, Hitoshi&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Forensic+Science+International%22&quot;&gt;Forensic Science International&lt;/searchLink&gt;. Aug2008, Vol. 179 Issue 2/3, p147-151. 5p.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Forensic+pathologists%22&quot;&gt;Forensic pathologists&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Adrenocorticotropic+hormone%22&quot;&gt;Adrenocorticotropic hormone&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Immunohistochemistry%22&quot;&gt;Immunohistochemistry&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Hypothermia%22&quot;&gt;Hypothermia&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Training%22&quot;&gt;Training&lt;/searchLink&gt;
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  Label: Abstract
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  Data: Abstract: Adrenocorticotropic hormone (ACTH) is involved in systemic reactions to stress. The aim of the present study was a comprehensive analysis of serum and cerebrospinal fluid (CSF) levels of ACTH, and the pituitary immunohistochemistry with special regard to fatal hypothermia in routine forensic autopsy cases (n =162: 5–97 years of age; 114 males and 48 females; 4h to 3 days postmortem, median, 19.2h). The ACTH concentrations were independent of the postmortem time, gender, or age of the subjects. The serum ACTH level was similar to the clinical reference value for sharp instrument injury, fire fatality, and hypothermia, but was lower in other groups including hyperthermia, in particular for asphyxia and poisoning. The CSF level was usually much higher than the serum level, but was significantly lower for hypothermia and hyperthermia than in other groups (p &lt;0.01). The rate of ACTH-immunopositivity in the anterior pituitary was low in cases of fatal hypothermia and hyperthermia, while it was high in cases of blunt injury, fire fatality, and acute ischemic heart disease. These observations showed that ACTH levels in the serum and CSF depended on the cause of death. The serum level was maintained despite a low CSF level and pituitary immunopositivity for fatal hypothermia, while the serum and CSF levels as well as pituitary immunopositivity were decreased for hyperthermia. [Copyright &amp;y&amp; Elsevier]
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  Data: &lt;i&gt;Copyright of Forensic Science International is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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    Identifiers:
      – Type: doi
        Value: 10.1016/j.forsciint.2008.04.023
    Languages:
      – Code: eng
        Text: English
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      Pagination:
        PageCount: 5
        StartPage: 147
    Subjects:
      – SubjectFull: Forensic pathologists
        Type: general
      – SubjectFull: Adrenocorticotropic hormone
        Type: general
      – SubjectFull: Immunohistochemistry
        Type: general
      – SubjectFull: Hypothermia
        Type: general
      – SubjectFull: Training
        Type: general
    Titles:
      – TitleFull: Postmortem biochemistry and immunohistochemistry of adrenocorticotropic hormone with special regard to fatal hypothermia
        Type: main
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            NameFull: Ishikawa, Takaki
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            NameFull: Quan, Li
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            NameFull: Li, Dong-Ri
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            NameFull: Zhao, Dong
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            NameFull: Michiue, Tomomi
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            NameFull: Hamel, Marianne
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            NameFull: Maeda, Hitoshi
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            – D: 06
              M: 08
              Text: Aug2008
              Type: published
              Y: 2008
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              Value: 179
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              Value: 2/3
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