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DNA adducts and PM10 exposure in traffic-exposed workers and urban residents from the EPIC-Florence City study

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Title: DNA adducts and PM10 exposure in traffic-exposed workers and urban residents from the EPIC-Florence City study
Authors: Palli, Domenico1 d.palli@cspo.it, Saieva, Calogero1, Munnia, Armelle2, Peluso, Marco2, Grechi, Daniele3 danielegrechi@virgilio.it, Zanna, Ines1, Caini, Saverio1, Decarli, Adriano4, Sera, Francesco1, Masala, Giovanna1
Source: Science of the Total Environment. Sep2008, Vol. 403 Issue 1-3, p105-112. 8p.
Subjects: Air pollution, Particulate matter, DNA adducts, Traffic police, Traffic congestion, Dose-response relationship in biochemistry, Genetic toxicology, Cancer risk factors
Geographic Terms: Florence (Italy), Italy
Abstract: Air pollution and particulate matter in urban areas have been associated with increased mortality from cardiovascular and respiratory diseases and increased cancer risk. Carcinogenic effects of particulate matter have been related to the contents of specific compounds, such as polycyclic aromatic hydrocarbons. The latter may form bulky DNA adducts, that may be considered as candidate markers of cancer risk. We have recently shown that traffic-exposed workers and the general population in Florence have divergent levels of DNA adducts, possibly related to different levels of exposure to genotoxic agents from vehicle emissions. In the current study, in a series of 214 Florence City healthy adults enrolled in a prospective study in the period 1993–1998 (152 residents / 62 traffic-exposed workers), we investigated the correlation between individual levels of DNA bulky adducts and PM10 exposure scores based on daily environmental measures provided by the local Environmental Protection Agency for the whole study period, by two types of urban monitoring stations (high- and low-traffic). We found that PM10 cumulative scores from high-traffic stations over the last 1–2 weeks prior to blood drawing significantly correlated (r =0.58, p =0.02) with DNA adduct levels among non-smoking traffic-exposed workers (but not among residents with no occupational exposure to vehicle emissions). A multivariate regression analysis adjusted for possible confounders confirmed these findings. PM10 scores from low-traffic stations did not show any correlation. These results show that DNA adduct levels in non-smoking workers reflect the average levels of exposure to PM10 in high-traffic urban areas experienced over a time period of 1–2 weeks. Since DNA adduct levels have been found predictive of lung cancer risk, our findings provide clues relevant to the reduction of genotoxic damage and possibly cancer risk among traffic-exposed urban workers. [Copyright &y& Elsevier]
Copyright of Science of the Total Environment is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: DNA adducts and PM<subscript>10</subscript> exposure in traffic-exposed workers and urban residents from the EPIC-Florence City study
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  Data: <searchLink fieldCode="AR" term="%22Palli%2C+Domenico%22">Palli, Domenico</searchLink><relatesTo>1</relatesTo><i> d.palli@cspo.it</i><br /><searchLink fieldCode="AR" term="%22Saieva%2C+Calogero%22">Saieva, Calogero</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Munnia%2C+Armelle%22">Munnia, Armelle</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Peluso%2C+Marco%22">Peluso, Marco</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Grechi%2C+Daniele%22">Grechi, Daniele</searchLink><relatesTo>3</relatesTo><i> danielegrechi@virgilio.it</i><br /><searchLink fieldCode="AR" term="%22Zanna%2C+Ines%22">Zanna, Ines</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Caini%2C+Saverio%22">Caini, Saverio</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Decarli%2C+Adriano%22">Decarli, Adriano</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Sera%2C+Francesco%22">Sera, Francesco</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Masala%2C+Giovanna%22">Masala, Giovanna</searchLink><relatesTo>1</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Science+of+the+Total+Environment%22">Science of the Total Environment</searchLink>. Sep2008, Vol. 403 Issue 1-3, p105-112. 8p.
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  Data: <searchLink fieldCode="DE" term="%22Air+pollution%22">Air pollution</searchLink><br /><searchLink fieldCode="DE" term="%22Particulate+matter%22">Particulate matter</searchLink><br /><searchLink fieldCode="DE" term="%22DNA+adducts%22">DNA adducts</searchLink><br /><searchLink fieldCode="DE" term="%22Traffic+police%22">Traffic police</searchLink><br /><searchLink fieldCode="DE" term="%22Traffic+congestion%22">Traffic congestion</searchLink><br /><searchLink fieldCode="DE" term="%22Dose-response+relationship+in+biochemistry%22">Dose-response relationship in biochemistry</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+toxicology%22">Genetic toxicology</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+risk+factors%22">Cancer risk factors</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22Florence+%28Italy%29%22">Florence (Italy)</searchLink><br /><searchLink fieldCode="DE" term="%22Italy%22">Italy</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Air pollution and particulate matter in urban areas have been associated with increased mortality from cardiovascular and respiratory diseases and increased cancer risk. Carcinogenic effects of particulate matter have been related to the contents of specific compounds, such as polycyclic aromatic hydrocarbons. The latter may form bulky DNA adducts, that may be considered as candidate markers of cancer risk. We have recently shown that traffic-exposed workers and the general population in Florence have divergent levels of DNA adducts, possibly related to different levels of exposure to genotoxic agents from vehicle emissions. In the current study, in a series of 214 Florence City healthy adults enrolled in a prospective study in the period 1993–1998 (152 residents / 62 traffic-exposed workers), we investigated the correlation between individual levels of DNA bulky adducts and PM10 exposure scores based on daily environmental measures provided by the local Environmental Protection Agency for the whole study period, by two types of urban monitoring stations (high- and low-traffic). We found that PM10 cumulative scores from high-traffic stations over the last 1–2 weeks prior to blood drawing significantly correlated (r =0.58, p =0.02) with DNA adduct levels among non-smoking traffic-exposed workers (but not among residents with no occupational exposure to vehicle emissions). A multivariate regression analysis adjusted for possible confounders confirmed these findings. PM10 scores from low-traffic stations did not show any correlation. These results show that DNA adduct levels in non-smoking workers reflect the average levels of exposure to PM10 in high-traffic urban areas experienced over a time period of 1–2 weeks. Since DNA adduct levels have been found predictive of lung cancer risk, our findings provide clues relevant to the reduction of genotoxic damage and possibly cancer risk among traffic-exposed urban workers. [Copyright &y& Elsevier]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Science of the Total Environment is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=33527680
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      – Type: doi
        Value: 10.1016/j.scitotenv.2008.05.041
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      – Code: eng
        Text: English
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        PageCount: 8
        StartPage: 105
    Subjects:
      – SubjectFull: Air pollution
        Type: general
      – SubjectFull: Particulate matter
        Type: general
      – SubjectFull: DNA adducts
        Type: general
      – SubjectFull: Traffic police
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      – SubjectFull: Traffic congestion
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      – SubjectFull: Dose-response relationship in biochemistry
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      – SubjectFull: Genetic toxicology
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      – SubjectFull: Cancer risk factors
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      – SubjectFull: Florence (Italy)
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      – SubjectFull: Italy
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      – TitleFull: DNA adducts and PM10 exposure in traffic-exposed workers and urban residents from the EPIC-Florence City study
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              M: 09
              Text: Sep2008
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