The Design and Characterization of an Ultrasound Phased Array Suitable for Deep Tissue Hyperthermia
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| Title: | The Design and Characterization of an Ultrasound Phased Array Suitable for Deep Tissue Hyperthermia |
|---|---|
| Authors: | Aitkenhead, Adam H.1 a.h.aitkenhead@warwick.ac.uk, Mills, John A.2, Wilson, Adrian J.1,2 |
| Source: | Ultrasound in Medicine & Biology. Nov2008, Vol. 34 Issue 11, p1793-1807. 15p. |
| Subjects: | Medical imaging systems, Diagnostic imaging, Phototherapy, Drug therapy |
| Abstract: | Abstract: In this paper we describe the design and evaluation of a planar phased-array ultrasound transducer suitable for producing localized hyperthermia in solid tumors deep within the body. Simulation using a customized version of Ultrasim has been used to determine the relationship between the size and position of the focus and parameters of the array. These parameters include the overall size of the array and the size, shape and distribution of the individual elements. A 15-element prototype array has been constructed using the results of the simulation. Beam profile measurements on this transducer made in an acoustic tank were compared with the beam profile predicted by simulation. The results showed good agreement in the shape of the focal region, but with the focus closer to the surface of the physical transducer when compared with the simulation and with small high-intensity areas between the surface of the transducer and the focus in the measured profile. A sensitivity analysis using a simulated factorial experiment indicated that the presence of a secondary vibrational mode within the elements of the array was the principal cause for both the shift in the position of the focus and for the unwanted maxima close to the surface of the array. The results also showed that the array was tolerant of a large variation in output intensity of the individual elements in the array in producing a focal region. Extrapolation of the results obtained in this study indicate that an array of 60 elements, based on the design described, driven by 550 V peak-to-peak pulses would be capable of producing a peak focal intensity of 50 Wcm−2 at a depth of 60 mm in tissue, which would be appropriate for hyperthermia used as an adjunct to radiotherapy or chemotherapy. (E-mail: a.h.aitkenhead@warwick.ac.uk) [Copyright &y& Elsevier] |
| Copyright of Ultrasound in Medicine & Biology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 34897297 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: The Design and Characterization of an Ultrasound Phased Array Suitable for Deep Tissue Hyperthermia – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Aitkenhead%2C+Adam+H%2E%22">Aitkenhead, Adam H.</searchLink><relatesTo>1</relatesTo><i> a.h.aitkenhead@warwick.ac.uk</i><br /><searchLink fieldCode="AR" term="%22Mills%2C+John+A%2E%22">Mills, John A.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Wilson%2C+Adrian+J%2E%22">Wilson, Adrian J.</searchLink><relatesTo>1,2</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Ultrasound+in+Medicine+%26+Biology%22">Ultrasound in Medicine & Biology</searchLink>. Nov2008, Vol. 34 Issue 11, p1793-1807. 15p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Medical+imaging+systems%22">Medical imaging systems</searchLink><br /><searchLink fieldCode="DE" term="%22Diagnostic+imaging%22">Diagnostic imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Phototherapy%22">Phototherapy</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+therapy%22">Drug therapy</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Abstract: In this paper we describe the design and evaluation of a planar phased-array ultrasound transducer suitable for producing localized hyperthermia in solid tumors deep within the body. Simulation using a customized version of Ultrasim has been used to determine the relationship between the size and position of the focus and parameters of the array. These parameters include the overall size of the array and the size, shape and distribution of the individual elements. A 15-element prototype array has been constructed using the results of the simulation. Beam profile measurements on this transducer made in an acoustic tank were compared with the beam profile predicted by simulation. The results showed good agreement in the shape of the focal region, but with the focus closer to the surface of the physical transducer when compared with the simulation and with small high-intensity areas between the surface of the transducer and the focus in the measured profile. A sensitivity analysis using a simulated factorial experiment indicated that the presence of a secondary vibrational mode within the elements of the array was the principal cause for both the shift in the position of the focus and for the unwanted maxima close to the surface of the array. The results also showed that the array was tolerant of a large variation in output intensity of the individual elements in the array in producing a focal region. Extrapolation of the results obtained in this study indicate that an array of 60 elements, based on the design described, driven by 550 V peak-to-peak pulses would be capable of producing a peak focal intensity of 50 Wcm−2 at a depth of 60 mm in tissue, which would be appropriate for hyperthermia used as an adjunct to radiotherapy or chemotherapy. (E-mail: a.h.aitkenhead@warwick.ac.uk) [Copyright &y& Elsevier] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Ultrasound in Medicine & Biology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.ultrasmedbio.2008.04.001 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 15 StartPage: 1793 Subjects: – SubjectFull: Medical imaging systems Type: general – SubjectFull: Diagnostic imaging Type: general – SubjectFull: Phototherapy Type: general – SubjectFull: Drug therapy Type: general Titles: – TitleFull: The Design and Characterization of an Ultrasound Phased Array Suitable for Deep Tissue Hyperthermia Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Aitkenhead, Adam H. – PersonEntity: Name: NameFull: Mills, John A. – PersonEntity: Name: NameFull: Wilson, Adrian J. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 11 Text: Nov2008 Type: published Y: 2008 Identifiers: – Type: issn-print Value: 03015629 Numbering: – Type: volume Value: 34 – Type: issue Value: 11 Titles: – TitleFull: Ultrasound in Medicine & Biology Type: main |
| ResultId | 1 |
