Controlled release of vitamin B2 using mesoporous materials functionalized with amine-bearing gate-like scaffoldings
Saved in:
| Title: | Controlled release of vitamin B |
|---|---|
| Authors: | Bernardos, Andrea1,2, Aznar, Elena1, Coll, Carmen1, Martínez-Mañez, Ramón1 rmaez@qim.upv.es, Barat, Jose Manuel2 jmbarat@tal.upv.es, Marcos, Ma. Dolores1, Sancenón, Félix1, Benito, Angel1, Soto, Juan1 |
| Source: | Journal of Controlled Release. Nov2008, Vol. 131 Issue 3, p181-189. 9p. |
| Subjects: | Vitamin B2, Controlled release drugs, Hydrogen-ion concentration, Polyamines, Porous materials |
| Abstract: | Abstract: A study on the controlled release of vitamin B2 in pure water from mesoporous silica-based materials containing a pH- and anion-controlled nano-supramolecular gate-like ensembles built up by anchoring suitable polyamines on the external surface is reported (solid S1). This solid contains the vitamin (the delivered molecule) onto the pores, whereas the amine-based gate-like ensemble is anchored on the pore outlets. To obtain solid S1 the mesoporous MCM-41 support was first synthesized using tetraethyl orthosilicate (TEOS) as hydrolytic inorganic precursor and the surfactant hexadecyltrimethylammonium bromide (CTAB) as porogen species. Calcination of the mesostructured phase resulted in the starting solid. Then, first the vitamin and the latter an excess of 3-[2-(2-aminoethylamino)ethylamino]propyl-trimethoxysilane were added to the suspension containing the MCM-41 scaffolding and stirred. Solid S1 was characterized using standard solid state procedures. It was found that the functionalization process and the inclusion of the vitamin on the pores do not modify the mesoporous structure of the starting material. Delivery studies in water were carried out at pH 2 and 7. At pH 2 all the anions studied (sulfate, phosphate, GMP and ATP) strongly hinder vitamin release (C anion =1×10−2 mol dm−3), whereas at pH 7 the delivery was observed for sulfate and GMP whereas the gate remained closed in the presence of ATP and phosphate. Selective delivery at neutral pH and no-liberation in acidic conditions can also be controlled with ATP and GMP using a suitable concentration of anion. The remarkable anion-controllable response of the gate-like ensemble at a certain pH can be explained in terms of anion complex formation with the tethered polyamines. Finally, selectivity patterns have been discussed in terms of kinetic rates of vitamin B2 release. The pH-controlled gate-like scaffoldings on S1 might be a suitable prototype for the development of orally applicable delivery systems designed to have the particular ability to protect the cargo from the acidic conditions of the stomach (acid pH, gate closed) but will release the load at the intestine (basic pH, gate open). [Copyright &y& Elsevier] |
| Copyright of Journal of Controlled Release is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
|---|---|
| Header | DbId: egs DbLabel: Engineering Source An: 34998013 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Controlled release of vitamin B<subscript>2</subscript> using mesoporous materials functionalized with amine-bearing gate-like scaffoldings – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Bernardos%2C+Andrea%22">Bernardos, Andrea</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Aznar%2C+Elena%22">Aznar, Elena</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Coll%2C+Carmen%22">Coll, Carmen</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Martínez-Mañez%2C+Ramón%22">Martínez-Mañez, Ramón</searchLink><relatesTo>1</relatesTo><i> rmaez@qim.upv.es</i><br /><searchLink fieldCode="AR" term="%22Barat%2C+Jose+Manuel%22">Barat, Jose Manuel</searchLink><relatesTo>2</relatesTo><i> jmbarat@tal.upv.es</i><br /><searchLink fieldCode="AR" term="%22Marcos%2C+Ma%2E+Dolores%22">Marcos, Ma. Dolores</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Sancenón%2C+Félix%22">Sancenón, Félix</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Benito%2C+Angel%22">Benito, Angel</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Soto%2C+Juan%22">Soto, Juan</searchLink><relatesTo>1</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Journal+of+Controlled+Release%22">Journal of Controlled Release</searchLink>. Nov2008, Vol. 131 Issue 3, p181-189. 9p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Vitamin+B2%22">Vitamin B2</searchLink><br /><searchLink fieldCode="DE" term="%22Controlled+release+drugs%22">Controlled release drugs</searchLink><br /><searchLink fieldCode="DE" term="%22Hydrogen-ion+concentration%22">Hydrogen-ion concentration</searchLink><br /><searchLink fieldCode="DE" term="%22Polyamines%22">Polyamines</searchLink><br /><searchLink fieldCode="DE" term="%22Porous+materials%22">Porous materials</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Abstract: A study on the controlled release of vitamin B2 in pure water from mesoporous silica-based materials containing a pH- and anion-controlled nano-supramolecular gate-like ensembles built up by anchoring suitable polyamines on the external surface is reported (solid S1). This solid contains the vitamin (the delivered molecule) onto the pores, whereas the amine-based gate-like ensemble is anchored on the pore outlets. To obtain solid S1 the mesoporous MCM-41 support was first synthesized using tetraethyl orthosilicate (TEOS) as hydrolytic inorganic precursor and the surfactant hexadecyltrimethylammonium bromide (CTAB) as porogen species. Calcination of the mesostructured phase resulted in the starting solid. Then, first the vitamin and the latter an excess of 3-[2-(2-aminoethylamino)ethylamino]propyl-trimethoxysilane were added to the suspension containing the MCM-41 scaffolding and stirred. Solid S1 was characterized using standard solid state procedures. It was found that the functionalization process and the inclusion of the vitamin on the pores do not modify the mesoporous structure of the starting material. Delivery studies in water were carried out at pH 2 and 7. At pH 2 all the anions studied (sulfate, phosphate, GMP and ATP) strongly hinder vitamin release (C anion =1×10−2 mol dm−3), whereas at pH 7 the delivery was observed for sulfate and GMP whereas the gate remained closed in the presence of ATP and phosphate. Selective delivery at neutral pH and no-liberation in acidic conditions can also be controlled with ATP and GMP using a suitable concentration of anion. The remarkable anion-controllable response of the gate-like ensemble at a certain pH can be explained in terms of anion complex formation with the tethered polyamines. Finally, selectivity patterns have been discussed in terms of kinetic rates of vitamin B2 release. The pH-controlled gate-like scaffoldings on S1 might be a suitable prototype for the development of orally applicable delivery systems designed to have the particular ability to protect the cargo from the acidic conditions of the stomach (acid pH, gate closed) but will release the load at the intestine (basic pH, gate open). [Copyright &y& Elsevier] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Journal of Controlled Release is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=34998013 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.jconrel.2008.07.037 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 181 Subjects: – SubjectFull: Vitamin B2 Type: general – SubjectFull: Controlled release drugs Type: general – SubjectFull: Hydrogen-ion concentration Type: general – SubjectFull: Polyamines Type: general – SubjectFull: Porous materials Type: general Titles: – TitleFull: Controlled release of vitamin B2 using mesoporous materials functionalized with amine-bearing gate-like scaffoldings Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Bernardos, Andrea – PersonEntity: Name: NameFull: Aznar, Elena – PersonEntity: Name: NameFull: Coll, Carmen – PersonEntity: Name: NameFull: Martínez-Mañez, Ramón – PersonEntity: Name: NameFull: Barat, Jose Manuel – PersonEntity: Name: NameFull: Marcos, Ma. Dolores – PersonEntity: Name: NameFull: Sancenón, Félix – PersonEntity: Name: NameFull: Benito, Angel – PersonEntity: Name: NameFull: Soto, Juan IsPartOfRelationships: – BibEntity: Dates: – D: 12 M: 11 Text: Nov2008 Type: published Y: 2008 Identifiers: – Type: issn-print Value: 01683659 Numbering: – Type: volume Value: 131 – Type: issue Value: 3 Titles: – TitleFull: Journal of Controlled Release Type: main |
| ResultId | 1 |
