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Quantifying the Dosimetric Trade-Offs When Using Intensity-Modulated Radiotherapy to Treat Concave Targets Containing Normal Tissues

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Title: Quantifying the Dosimetric Trade-Offs When Using Intensity-Modulated Radiotherapy to Treat Concave Targets Containing Normal Tissues
Authors: Reese, Adam S. adam.reese@duke.edu, Das, Shiva K.1, Kirkpatrick, John P.1, Marks, Lawrence B.1
Source: International Journal of Radiation Oncology, Biology, Physics. Feb2009, Vol. 73 Issue 2, p585-593. 9p.
Subjects: Radiation dosimetry, Cancer radiotherapy, Targeted drug delivery, Tissues, Medical care, Radiation doses
Abstract: Purpose: To quantitatively assess the relationship between intensity-modulated radiotherapy (IMRT)–driven sparing of dose to normal tissues located “within” concave targets with heterogeneity in dose delivered to the target and redistribution of dose to normal tissue beyond the concavity. Methods and Materials: A combination of idealized and real-patient volumes was considered. Multiple IMRT plans were generated with progressive dose restriction to the normal tissue within the concavity. We quantified the impact of such sparing on the heterogeneity of dose within the target tissue itself, and the dose received by normal tissues beyond the concavity. Results: As the dose to the normal tissue concavity region is reduced, the heterogeneity in dose delivered to the target increases in an exponential fashion. Furthermore, there is a rapid increase in redistributed dose to other normal tissue regions, particularly to the other normal tissues immediately adjacent to the outside edges of the concavity. Increasingly restricting dose to these adjacent normal tissue regions resulted in increasing dose to the normal tissue in the concavity and increasing dose heterogeneity in the target volume. Conclusions: For targets with concavities, there are dosimetric consequences associated with reducing dose to normal tissue located within these concavities. There appears to be a trade-off between the heterogeneity in dose delivered to the target, the mean dose to the concavity, and the redistributed dose to other normal tissues. Understanding the interaction between these dosimetric factors can aid the planner in assessing the feasibility of a desired dose distribution. [Copyright &y& Elsevier]
Copyright of International Journal of Radiation Oncology, Biology, Physics is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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  Data: Quantifying the Dosimetric Trade-Offs When Using Intensity-Modulated Radiotherapy to Treat Concave Targets Containing Normal Tissues
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  Data: Purpose: To quantitatively assess the relationship between intensity-modulated radiotherapy (IMRT)–driven sparing of dose to normal tissues located “within” concave targets with heterogeneity in dose delivered to the target and redistribution of dose to normal tissue beyond the concavity. Methods and Materials: A combination of idealized and real-patient volumes was considered. Multiple IMRT plans were generated with progressive dose restriction to the normal tissue within the concavity. We quantified the impact of such sparing on the heterogeneity of dose within the target tissue itself, and the dose received by normal tissues beyond the concavity. Results: As the dose to the normal tissue concavity region is reduced, the heterogeneity in dose delivered to the target increases in an exponential fashion. Furthermore, there is a rapid increase in redistributed dose to other normal tissue regions, particularly to the other normal tissues immediately adjacent to the outside edges of the concavity. Increasingly restricting dose to these adjacent normal tissue regions resulted in increasing dose to the normal tissue in the concavity and increasing dose heterogeneity in the target volume. Conclusions: For targets with concavities, there are dosimetric consequences associated with reducing dose to normal tissue located within these concavities. There appears to be a trade-off between the heterogeneity in dose delivered to the target, the mean dose to the concavity, and the redistributed dose to other normal tissues. Understanding the interaction between these dosimetric factors can aid the planner in assessing the feasibility of a desired dose distribution. [Copyright &y& Elsevier]
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  Data: <i>Copyright of International Journal of Radiation Oncology, Biology, Physics is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – SubjectFull: Targeted drug delivery
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              Text: Feb2009
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