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Absorption of 10-hydroxycamptothecin into the coat of magnetoliposomes

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Title: Absorption of 10-hydroxycamptothecin into the coat of magnetoliposomes
Authors: Hodenius, M.A.J.1 hodenius@hia.rwth-aachen.de, Schmitz-Rode, T.1, Baumann, M.1, Ivanova, G.1, Wong, J.E.2, Mang, T.3, Haulena, F.3, Soenen, S.J.H.4, De Cuyper, M.4
Source: Colloids & Surfaces A: Physicochemical & Engineering Aspects. Jul2009, Vol. 343 Issue 1-3, p20-23. 4p.
Subjects: Camptothecin, Liposomes, Absorption, Magnetite, Nanostructured materials, Metal clusters, Colloids in medicine, Binding sites, Drug interactions
Abstract: Abstract: The work deals with the binding of 10-hydroxycamptothecin (HCPT) in the coating of so-called magnetoliposomes (MLs). The latter consist of nanometer-sized crystalline magnetite (Fe3O4) cores surrounded by a phospholipid bilayer, which for the present study is built up of either dipalmitoylphosphatidylcholine (DPPC) or mixtures of DPPC with dipalmitoylphosphatidylglycerol (DPPG) (DPPC/DPPG molar ratios of 4/1, 2/1, 1/1 and 1/3). Partitioning of HCPT in the ML coat significantly improves as the DPPG content in the ML coat increases, suggesting the importance of H-bridges between DPPG and HCPT in the absorption process. In contrast to the behaviour of ‘classical’ phospholipid membranes which expand upon drug binding, it is calculated that with the phospholipid bilayer immobilized on the Fe3O4 surface 2.6±0.5 phospholipid molecules have to leave the membrane for insertion of 1 HCPT molecule. The potential of the ML-drug structures as promising theranostics (i.e. nanocolloids with both therapeutic and diagnostic features) is briefly discussed. [Copyright &y& Elsevier]
Copyright of Colloids & Surfaces A: Physicochemical & Engineering Aspects is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 41241177
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Absorption of 10-hydroxycamptothecin into the coat of magnetoliposomes
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  Data: <searchLink fieldCode="AR" term="%22Hodenius%2C+M%2EA%2EJ%2E%22">Hodenius, M.A.J.</searchLink><relatesTo>1</relatesTo><i> hodenius@hia.rwth-aachen.de</i><br /><searchLink fieldCode="AR" term="%22Schmitz-Rode%2C+T%2E%22">Schmitz-Rode, T.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Baumann%2C+M%2E%22">Baumann, M.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Ivanova%2C+G%2E%22">Ivanova, G.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Wong%2C+J%2EE%2E%22">Wong, J.E.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Mang%2C+T%2E%22">Mang, T.</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Haulena%2C+F%2E%22">Haulena, F.</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Soenen%2C+S%2EJ%2EH%2E%22">Soenen, S.J.H.</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22De+Cuyper%2C+M%2E%22">De Cuyper, M.</searchLink><relatesTo>4</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Colloids+%26+Surfaces+A%3A+Physicochemical+%26+Engineering+Aspects%22">Colloids & Surfaces A: Physicochemical & Engineering Aspects</searchLink>. Jul2009, Vol. 343 Issue 1-3, p20-23. 4p.
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  Data: <searchLink fieldCode="DE" term="%22Camptothecin%22">Camptothecin</searchLink><br /><searchLink fieldCode="DE" term="%22Liposomes%22">Liposomes</searchLink><br /><searchLink fieldCode="DE" term="%22Absorption%22">Absorption</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetite%22">Magnetite</searchLink><br /><searchLink fieldCode="DE" term="%22Nanostructured+materials%22">Nanostructured materials</searchLink><br /><searchLink fieldCode="DE" term="%22Metal+clusters%22">Metal clusters</searchLink><br /><searchLink fieldCode="DE" term="%22Colloids+in+medicine%22">Colloids in medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Binding+sites%22">Binding sites</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+interactions%22">Drug interactions</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Abstract: The work deals with the binding of 10-hydroxycamptothecin (HCPT) in the coating of so-called magnetoliposomes (MLs). The latter consist of nanometer-sized crystalline magnetite (Fe3O4) cores surrounded by a phospholipid bilayer, which for the present study is built up of either dipalmitoylphosphatidylcholine (DPPC) or mixtures of DPPC with dipalmitoylphosphatidylglycerol (DPPG) (DPPC/DPPG molar ratios of 4/1, 2/1, 1/1 and 1/3). Partitioning of HCPT in the ML coat significantly improves as the DPPG content in the ML coat increases, suggesting the importance of H-bridges between DPPG and HCPT in the absorption process. In contrast to the behaviour of ‘classical’ phospholipid membranes which expand upon drug binding, it is calculated that with the phospholipid bilayer immobilized on the Fe3O4 surface 2.6±0.5 phospholipid molecules have to leave the membrane for insertion of 1 HCPT molecule. The potential of the ML-drug structures as promising theranostics (i.e. nanocolloids with both therapeutic and diagnostic features) is briefly discussed. [Copyright &y& Elsevier]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Colloids & Surfaces A: Physicochemical & Engineering Aspects is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1016/j.colsurfa.2009.01.024
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 4
        StartPage: 20
    Subjects:
      – SubjectFull: Camptothecin
        Type: general
      – SubjectFull: Liposomes
        Type: general
      – SubjectFull: Absorption
        Type: general
      – SubjectFull: Magnetite
        Type: general
      – SubjectFull: Nanostructured materials
        Type: general
      – SubjectFull: Metal clusters
        Type: general
      – SubjectFull: Colloids in medicine
        Type: general
      – SubjectFull: Binding sites
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      – SubjectFull: Drug interactions
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      – TitleFull: Absorption of 10-hydroxycamptothecin into the coat of magnetoliposomes
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              Text: Jul2009
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