View in EDS

Calculations of dose distributions in the lungs of a rat model irradiated in the thermal column of the TRIGA reactor in Pavia

Saved in:
Bibliographic Details
Title: Calculations of dose distributions in the lungs of a rat model irradiated in the thermal column of the TRIGA reactor in Pavia
Authors: Protti, N.1,2 nicoletta.protti@pv.infn.it, Bortolussi, S.1,2, Stella, S.1,2, Gadan, M.A.1, De Bari, A.1,2, Ballarini, F.1,2, Bruschi, P.1, Ferrari, C.3, Clerici, A.M.3, Zonta, C.3, Bakeine, J.G.1, Dionigi, P.3, Zonta, A.3, Altieri, S.1,2
Source: Applied Radiation & Isotopes. Jul2009 Supplement, Vol. 67 Issue 7/8, pS210-S213. 0p.
Subjects: Radiation doses, Laboratory rats, Animal models in research, Geothermal reactors, Boron-neutron capture therapy, Treatment of lung tumors
Geographic Terms: Pavia (Italy), Italy
Abstract: Abstract: To test the possibility to apply boron neutron capture therapy (BNCT) to lung tumors, some rats are planned to be irradiated in the thermal column of the TRIGA reactor of the University of Pavia. Before the irradiation, lung metastases will be induced in BDIX rats, which will be subsequently infused with boronophenylalanine (BPA). During the irradiation, the rats will be positioned in a box designed to shield the whole animal except the thorax area. In order to optimize the irradiation set-up and to design a suitable shielding box, a set of calculations were performed with the MCNP Monte Carlo transport code. A rat model was constructed using the MCNP geometry capabilities and was positioned in a box with walls filled with lithium carbonate. A window was opened in front of the lung region. Different shapes of the holder and of the window were tested and analyzed in terms of the dose distribution obtained in the lungs and of the dose absorbed by the radiosensitive organs in the rat. The best configuration of the holder ensures an almost uniform thermal neutron flux inside the lungs (Φ max/Φ min=1.5), an irradiation time about 10min long, to deliver at least 40Gyw to the tumor, a mean lung dose of 5.9±0.4Gyw, and doses absorbed by all the other healthy tissues below the tolerance limits. [Copyright &y& Elsevier]
Copyright of Applied Radiation & Isotopes is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
FullText Text:
  Availability: 0
Header DbId: egs
DbLabel: Engineering Source
An: 41688466
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Calculations of dose distributions in the lungs of a rat model irradiated in the thermal column of the TRIGA reactor in Pavia
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Protti%2C+N%2E%22">Protti, N.</searchLink><relatesTo>1,2</relatesTo><i> nicoletta.protti@pv.infn.it</i><br /><searchLink fieldCode="AR" term="%22Bortolussi%2C+S%2E%22">Bortolussi, S.</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Stella%2C+S%2E%22">Stella, S.</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Gadan%2C+M%2EA%2E%22">Gadan, M.A.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22De+Bari%2C+A%2E%22">De Bari, A.</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Ballarini%2C+F%2E%22">Ballarini, F.</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Bruschi%2C+P%2E%22">Bruschi, P.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Ferrari%2C+C%2E%22">Ferrari, C.</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Clerici%2C+A%2EM%2E%22">Clerici, A.M.</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Zonta%2C+C%2E%22">Zonta, C.</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Bakeine%2C+J%2EG%2E%22">Bakeine, J.G.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Dionigi%2C+P%2E%22">Dionigi, P.</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Zonta%2C+A%2E%22">Zonta, A.</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Altieri%2C+S%2E%22">Altieri, S.</searchLink><relatesTo>1,2</relatesTo>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Applied+Radiation+%26+Isotopes%22">Applied Radiation & Isotopes</searchLink>. Jul2009 Supplement, Vol. 67 Issue 7/8, pS210-S213. 0p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Radiation+doses%22">Radiation doses</searchLink><br /><searchLink fieldCode="DE" term="%22Laboratory+rats%22">Laboratory rats</searchLink><br /><searchLink fieldCode="DE" term="%22Animal+models+in+research%22">Animal models in research</searchLink><br /><searchLink fieldCode="DE" term="%22Geothermal+reactors%22">Geothermal reactors</searchLink><br /><searchLink fieldCode="DE" term="%22Boron-neutron+capture+therapy%22">Boron-neutron capture therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+of+lung+tumors%22">Treatment of lung tumors</searchLink>
– Name: SubjectGeographic
  Label: Geographic Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Pavia+%28Italy%29%22">Pavia (Italy)</searchLink><br /><searchLink fieldCode="DE" term="%22Italy%22">Italy</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Abstract: To test the possibility to apply boron neutron capture therapy (BNCT) to lung tumors, some rats are planned to be irradiated in the thermal column of the TRIGA reactor of the University of Pavia. Before the irradiation, lung metastases will be induced in BDIX rats, which will be subsequently infused with boronophenylalanine (BPA). During the irradiation, the rats will be positioned in a box designed to shield the whole animal except the thorax area. In order to optimize the irradiation set-up and to design a suitable shielding box, a set of calculations were performed with the MCNP Monte Carlo transport code. A rat model was constructed using the MCNP geometry capabilities and was positioned in a box with walls filled with lithium carbonate. A window was opened in front of the lung region. Different shapes of the holder and of the window were tested and analyzed in terms of the dose distribution obtained in the lungs and of the dose absorbed by the radiosensitive organs in the rat. The best configuration of the holder ensures an almost uniform thermal neutron flux inside the lungs (Φ max/Φ min=1.5), an irradiation time about 10min long, to deliver at least 40Gyw to the tumor, a mean lung dose of 5.9±0.4Gyw, and doses absorbed by all the other healthy tissues below the tolerance limits. [Copyright &y& Elsevier]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Applied Radiation & Isotopes is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=41688466
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.apradiso.2009.03.052
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 0
        StartPage: S210
    Subjects:
      – SubjectFull: Radiation doses
        Type: general
      – SubjectFull: Laboratory rats
        Type: general
      – SubjectFull: Animal models in research
        Type: general
      – SubjectFull: Geothermal reactors
        Type: general
      – SubjectFull: Boron-neutron capture therapy
        Type: general
      – SubjectFull: Treatment of lung tumors
        Type: general
      – SubjectFull: Pavia (Italy)
        Type: general
      – SubjectFull: Italy
        Type: general
    Titles:
      – TitleFull: Calculations of dose distributions in the lungs of a rat model irradiated in the thermal column of the TRIGA reactor in Pavia
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Protti, N.
      – PersonEntity:
          Name:
            NameFull: Bortolussi, S.
      – PersonEntity:
          Name:
            NameFull: Stella, S.
      – PersonEntity:
          Name:
            NameFull: Gadan, M.A.
      – PersonEntity:
          Name:
            NameFull: De Bari, A.
      – PersonEntity:
          Name:
            NameFull: Ballarini, F.
      – PersonEntity:
          Name:
            NameFull: Bruschi, P.
      – PersonEntity:
          Name:
            NameFull: Ferrari, C.
      – PersonEntity:
          Name:
            NameFull: Clerici, A.M.
      – PersonEntity:
          Name:
            NameFull: Zonta, C.
      – PersonEntity:
          Name:
            NameFull: Bakeine, J.G.
      – PersonEntity:
          Name:
            NameFull: Dionigi, P.
      – PersonEntity:
          Name:
            NameFull: Zonta, A.
      – PersonEntity:
          Name:
            NameFull: Altieri, S.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 02
              M: 07
              Text: Jul2009 Supplement
              Type: published
              Y: 2009
          Identifiers:
            – Type: issn-print
              Value: 09698043
          Numbering:
            – Type: volume
              Value: 67
            – Type: issue
              Value: 7/8
          Titles:
            – TitleFull: Applied Radiation & Isotopes
              Type: main
ResultId 1