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Effect of drug-light interval on the mode of action of Photofrin photodynamic therapy in a mouse tumor model.

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Title: Effect of drug-light interval on the mode of action of Photofrin photodynamic therapy in a mouse tumor model.
Authors: Li-Bo Li1 li•libo2008@yahoo.com.cn, Rong-Cheng Luo1, Li, Li-Bo2 (AUTHOR), Luo, Rong-Cheng (AUTHOR)
Source: Lasers in Medical Science. Jul2009, Vol. 24 Issue 4, p597-603. 7p. 3 Color Photographs, 1 Diagram, 1 Graph.
Subjects: Drug efficacy, Photochemotherapy, Tumor treatment, Medical lasers, Irradiation, Thrombosis, Animal experimentation, Biological models, Comparative studies, Electron microscopy, Lasers, Research methodology, Medical cooperation, Mice, Photosensitizers, Porphyrins, Research, Sarcoma, Skin, Time, Evaluation research, Therapeutics
Abstract: Our objective was to examine the effect of time intervals between Photofrin injection and laser irradiation [i.e., drug-light interval (DLI)] on the mode of action of Photofrin photodynamic therapy (PDT). Kunming mice transplanted with sarcoma-180 cells were used as an animal model. The tumor-bearing mice in the control group were given neither photosensitizer nor laser irradiation. PDT groups were given intravenous (i.v.) injection of Photofrin (7.5 mg/kg) prior to being irradiated with a 630 nm laser at 120 J/cm(2) at different DLIs (1 min-48 h). Tumors and overlying skin were visually examined daily. Histopathological and electron microscopic examinations were carried out 48 h after PDT. Survival rates were recorded. The mice in the groups that had experienced short DLIs (<60 min) showed stronger skin reactions than the groups subjected to long DLIs (>6 h). Histological examination showed that antitumor effects were achieved mainly by the destruction of tumor blood vessels and the formation of thrombosis at short DLIs, whereas, at long DLIs, the tumor cells were killed directly by PDT-mediated cytotoxicity. Electron microscopy revealed various degrees of mitochondrial swelling. The survival rate of the mice subjected to long DLIs was slightly higher than that of the mice subjected to short DLIs. Both vascular (e.g., tumor vessel destruction) and cellular (e.g., cytotoxicity) effects contributed to Photofrin PDT-induced tumor ablation. [ABSTRACT FROM AUTHOR]
Copyright of Lasers in Medical Science is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Effect of drug-light interval on the mode of action of Photofrin photodynamic therapy in a mouse tumor model.
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  Data: Our objective was to examine the effect of time intervals between Photofrin injection and laser irradiation [i.e., drug-light interval (DLI)] on the mode of action of Photofrin photodynamic therapy (PDT). Kunming mice transplanted with sarcoma-180 cells were used as an animal model. The tumor-bearing mice in the control group were given neither photosensitizer nor laser irradiation. PDT groups were given intravenous (i.v.) injection of Photofrin (7.5 mg/kg) prior to being irradiated with a 630 nm laser at 120 J/cm(2) at different DLIs (1 min-48 h). Tumors and overlying skin were visually examined daily. Histopathological and electron microscopic examinations were carried out 48 h after PDT. Survival rates were recorded. The mice in the groups that had experienced short DLIs (&lt;60 min) showed stronger skin reactions than the groups subjected to long DLIs (&gt;6 h). Histological examination showed that antitumor effects were achieved mainly by the destruction of tumor blood vessels and the formation of thrombosis at short DLIs, whereas, at long DLIs, the tumor cells were killed directly by PDT-mediated cytotoxicity. Electron microscopy revealed various degrees of mitochondrial swelling. The survival rate of the mice subjected to long DLIs was slightly higher than that of the mice subjected to short DLIs. Both vascular (e.g., tumor vessel destruction) and cellular (e.g., cytotoxicity) effects contributed to Photofrin PDT-induced tumor ablation. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Lasers in Medical Science is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1007/s10103-008-0620-9
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 7
        StartPage: 597
    Subjects:
      – SubjectFull: Drug efficacy
        Type: general
      – SubjectFull: Photochemotherapy
        Type: general
      – SubjectFull: Tumor treatment
        Type: general
      – SubjectFull: Medical lasers
        Type: general
      – SubjectFull: Irradiation
        Type: general
      – SubjectFull: Thrombosis
        Type: general
      – SubjectFull: Animal experimentation
        Type: general
      – SubjectFull: Biological models
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      – SubjectFull: Comparative studies
        Type: general
      – SubjectFull: Electron microscopy
        Type: general
      – SubjectFull: Lasers
        Type: general
      – SubjectFull: Research methodology
        Type: general
      – SubjectFull: Medical cooperation
        Type: general
      – SubjectFull: Mice
        Type: general
      – SubjectFull: Photosensitizers
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      – SubjectFull: Porphyrins
        Type: general
      – SubjectFull: Research
        Type: general
      – SubjectFull: Sarcoma
        Type: general
      – SubjectFull: Skin
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      – SubjectFull: Time
        Type: general
      – SubjectFull: Evaluation research
        Type: general
      – SubjectFull: Therapeutics
        Type: general
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      – TitleFull: Effect of drug-light interval on the mode of action of Photofrin photodynamic therapy in a mouse tumor model.
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            NameFull: Li-Bo Li
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            NameFull: Rong-Cheng Luo
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          Dates:
            – D: 01
              M: 07
              Text: Jul2009
              Type: published
              Y: 2009
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              Value: 24
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              Value: 4
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            – TitleFull: Lasers in Medical Science
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