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Cross reactions elicited by serum 17-OH progesterone and 11-desoxycortisol in cortisol assays

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Title: Cross reactions elicited by serum 17-OH progesterone and 11-desoxycortisol in cortisol assays
Authors: Brossaud, Julie1 julie.brossaud@u-bordeaux2.fr, Barat, Pascal2, Gualde, Dominique1, Corcuff, Jean-Benoît1
Source: Clinica Chimica Acta. Sep2009, Vol. 407 Issue 1/2, p72-74. 3p.
Subjects: Cross reactions (Immunology), Progesterone, Serum, Hydrocortisone, Pathological physiology, Hyperplasia, Adrenal cortex, Metopirone, Cancer
Abstract: Abstract: Background: Different pathophysiological situations such as congenital adrenal hyperplasia, adrenocortical carcinoma, metyrapone treatment, etc. elicit specificity problems with serum cortisol assay. Methods: We assayed cortisol using 2 kits and performed cross reaction studies as well as multiple regression analysis using 2 other steroids: 11-desoxycortisol and 17-OH progesterone. Results: Analysis showed the existence of an analytical bias. Importantly, significantly different biases were demonstrated in newborns or patients taking metyrapone. Multiple regression analysis and cross reaction studies showed that 11-desoxycortisol level significantly influenced cortisol determination. Moreover, despite using the normal ranges provided by manufacturers discrepant results occurred such as 17% discordance in the diagnosis of hypocorticism in infants. Conclusion: We wish to raise awareness about the consequences of the (lack of) specificity of cortisol assays with regard to the evaluation of hypocorticism in infants or when “unusual” steroids may be increased. [Copyright &y& Elsevier]
Copyright of Clinica Chimica Acta is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
An: 43528303
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Cross reactions elicited by serum 17-OH progesterone and 11-desoxycortisol in cortisol assays
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  Data: <searchLink fieldCode="AR" term="%22Brossaud%2C+Julie%22">Brossaud, Julie</searchLink><relatesTo>1</relatesTo><i> julie.brossaud@u-bordeaux2.fr</i><br /><searchLink fieldCode="AR" term="%22Barat%2C+Pascal%22">Barat, Pascal</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Gualde%2C+Dominique%22">Gualde, Dominique</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Corcuff%2C+Jean-Benoît%22">Corcuff, Jean-Benoît</searchLink><relatesTo>1</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Clinica+Chimica+Acta%22">Clinica Chimica Acta</searchLink>. Sep2009, Vol. 407 Issue 1/2, p72-74. 3p.
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  Data: <searchLink fieldCode="DE" term="%22Cross+reactions+%28Immunology%29%22">Cross reactions (Immunology)</searchLink><br /><searchLink fieldCode="DE" term="%22Progesterone%22">Progesterone</searchLink><br /><searchLink fieldCode="DE" term="%22Serum%22">Serum</searchLink><br /><searchLink fieldCode="DE" term="%22Hydrocortisone%22">Hydrocortisone</searchLink><br /><searchLink fieldCode="DE" term="%22Pathological+physiology%22">Pathological physiology</searchLink><br /><searchLink fieldCode="DE" term="%22Hyperplasia%22">Hyperplasia</searchLink><br /><searchLink fieldCode="DE" term="%22Adrenal+cortex%22">Adrenal cortex</searchLink><br /><searchLink fieldCode="DE" term="%22Metopirone%22">Metopirone</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer%22">Cancer</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Abstract: Background: Different pathophysiological situations such as congenital adrenal hyperplasia, adrenocortical carcinoma, metyrapone treatment, etc. elicit specificity problems with serum cortisol assay. Methods: We assayed cortisol using 2 kits and performed cross reaction studies as well as multiple regression analysis using 2 other steroids: 11-desoxycortisol and 17-OH progesterone. Results: Analysis showed the existence of an analytical bias. Importantly, significantly different biases were demonstrated in newborns or patients taking metyrapone. Multiple regression analysis and cross reaction studies showed that 11-desoxycortisol level significantly influenced cortisol determination. Moreover, despite using the normal ranges provided by manufacturers discrepant results occurred such as 17% discordance in the diagnosis of hypocorticism in infants. Conclusion: We wish to raise awareness about the consequences of the (lack of) specificity of cortisol assays with regard to the evaluation of hypocorticism in infants or when “unusual” steroids may be increased. [Copyright &y& Elsevier]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of Clinica Chimica Acta is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1016/j.cca.2009.05.019
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      – Code: eng
        Text: English
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        PageCount: 3
        StartPage: 72
    Subjects:
      – SubjectFull: Cross reactions (Immunology)
        Type: general
      – SubjectFull: Progesterone
        Type: general
      – SubjectFull: Serum
        Type: general
      – SubjectFull: Hydrocortisone
        Type: general
      – SubjectFull: Pathological physiology
        Type: general
      – SubjectFull: Hyperplasia
        Type: general
      – SubjectFull: Adrenal cortex
        Type: general
      – SubjectFull: Metopirone
        Type: general
      – SubjectFull: Cancer
        Type: general
    Titles:
      – TitleFull: Cross reactions elicited by serum 17-OH progesterone and 11-desoxycortisol in cortisol assays
        Type: main
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            NameFull: Brossaud, Julie
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            NameFull: Barat, Pascal
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            NameFull: Gualde, Dominique
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            NameFull: Corcuff, Jean-Benoît
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            – D: 03
              M: 09
              Text: Sep2009
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              Y: 2009
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