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Synthesis, structure and biological activity of amide-functionalized titanocenyls: Improving their cytotoxic properties

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Title: Synthesis, structure and biological activity of amide-functionalized titanocenyls: Improving their cytotoxic properties
Authors: Gao, Li Ming1, Matta, Jaime2, Rheingold, Arnold L.3, Meléndez, Enrique1 enrique.melendez@upr.edu
Source: Journal of Organometallic Chemistry. Dec2009, Vol. 694 Issue 26, p4134-4139. 6p.
Subjects: Complex compounds synthesis, Molecular structure, Amides, Cell-mediated cytotoxicity, Solid state chemistry, Organotitanium compounds, X-ray diffraction, Cancer cells
Abstract: Abstract: Nine amide-functionalized titanocenyls have been synthesized and characterized by spectroscopic and analytical methods and the solid state structure of Cp(CpCO-NH-C6H4-OCF3)TiCl2 was determined by single crystal X-ray diffraction. X-ray analysis of Cp(CpCO-NH-C6H4-OCF3)TiCl2 showed that titanium is in a pseudo tetrahedral geometry and contains a Ti–O(amide) coordination. In principle, Ti–O coordination should provide more hydrolytic stability to the corresponding titanocenyls than titanocene dichloride. The cytotoxic activities of these amide-functionalized titanocenyls on HT-29 colon cancer cell line were determined by MTT assay to elucidate structure-activity relationship. All complexes were more cytotoxic than titanocene dichloride and there is no correlation between the para substituents on the phenyl ring and their cytotoxicities. [Copyright &y& Elsevier]
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Database: Engineering Source
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Abstract:Abstract: Nine amide-functionalized titanocenyls have been synthesized and characterized by spectroscopic and analytical methods and the solid state structure of Cp(CpCO-NH-C6H4-OCF3)TiCl2 was determined by single crystal X-ray diffraction. X-ray analysis of Cp(CpCO-NH-C6H4-OCF3)TiCl2 showed that titanium is in a pseudo tetrahedral geometry and contains a Ti–O(amide) coordination. In principle, Ti–O coordination should provide more hydrolytic stability to the corresponding titanocenyls than titanocene dichloride. The cytotoxic activities of these amide-functionalized titanocenyls on HT-29 colon cancer cell line were determined by MTT assay to elucidate structure-activity relationship. All complexes were more cytotoxic than titanocene dichloride and there is no correlation between the para substituents on the phenyl ring and their cytotoxicities. [Copyright &y& Elsevier]
ISSN:0022328X
DOI:10.1016/j.jorganchem.2009.09.016