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Synthesis, structure and biological activity of amide-functionalized titanocenyls: Improving their cytotoxic properties

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Title: Synthesis, structure and biological activity of amide-functionalized titanocenyls: Improving their cytotoxic properties
Authors: Gao, Li Ming1, Matta, Jaime2, Rheingold, Arnold L.3, Meléndez, Enrique1 enrique.melendez@upr.edu
Source: Journal of Organometallic Chemistry. Dec2009, Vol. 694 Issue 26, p4134-4139. 6p.
Subjects: Complex compounds synthesis, Molecular structure, Amides, Cell-mediated cytotoxicity, Solid state chemistry, Organotitanium compounds, X-ray diffraction, Cancer cells
Abstract: Abstract: Nine amide-functionalized titanocenyls have been synthesized and characterized by spectroscopic and analytical methods and the solid state structure of Cp(CpCO-NH-C6H4-OCF3)TiCl2 was determined by single crystal X-ray diffraction. X-ray analysis of Cp(CpCO-NH-C6H4-OCF3)TiCl2 showed that titanium is in a pseudo tetrahedral geometry and contains a Ti–O(amide) coordination. In principle, Ti–O coordination should provide more hydrolytic stability to the corresponding titanocenyls than titanocene dichloride. The cytotoxic activities of these amide-functionalized titanocenyls on HT-29 colon cancer cell line were determined by MTT assay to elucidate structure-activity relationship. All complexes were more cytotoxic than titanocene dichloride and there is no correlation between the para substituents on the phenyl ring and their cytotoxicities. [Copyright &y& Elsevier]
Copyright of Journal of Organometallic Chemistry is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 45008866
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PubTypeId: academicJournal
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  Data: Synthesis, structure and biological activity of amide-functionalized titanocenyls: Improving their cytotoxic properties
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Organometallic+Chemistry%22">Journal of Organometallic Chemistry</searchLink>. Dec2009, Vol. 694 Issue 26, p4134-4139. 6p.
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  Data: <searchLink fieldCode="DE" term="%22Complex+compounds+synthesis%22">Complex compounds synthesis</searchLink><br /><searchLink fieldCode="DE" term="%22Molecular+structure%22">Molecular structure</searchLink><br /><searchLink fieldCode="DE" term="%22Amides%22">Amides</searchLink><br /><searchLink fieldCode="DE" term="%22Cell-mediated+cytotoxicity%22">Cell-mediated cytotoxicity</searchLink><br /><searchLink fieldCode="DE" term="%22Solid+state+chemistry%22">Solid state chemistry</searchLink><br /><searchLink fieldCode="DE" term="%22Organotitanium+compounds%22">Organotitanium compounds</searchLink><br /><searchLink fieldCode="DE" term="%22X-ray+diffraction%22">X-ray diffraction</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+cells%22">Cancer cells</searchLink>
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  Data: Abstract: Nine amide-functionalized titanocenyls have been synthesized and characterized by spectroscopic and analytical methods and the solid state structure of Cp(CpCO-NH-C6H4-OCF3)TiCl2 was determined by single crystal X-ray diffraction. X-ray analysis of Cp(CpCO-NH-C6H4-OCF3)TiCl2 showed that titanium is in a pseudo tetrahedral geometry and contains a Ti–O(amide) coordination. In principle, Ti–O coordination should provide more hydrolytic stability to the corresponding titanocenyls than titanocene dichloride. The cytotoxic activities of these amide-functionalized titanocenyls on HT-29 colon cancer cell line were determined by MTT assay to elucidate structure-activity relationship. All complexes were more cytotoxic than titanocene dichloride and there is no correlation between the para substituents on the phenyl ring and their cytotoxicities. [Copyright &y& Elsevier]
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  Data: <i>Copyright of Journal of Organometallic Chemistry is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1016/j.jorganchem.2009.09.016
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      – Code: eng
        Text: English
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        StartPage: 4134
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      – SubjectFull: Complex compounds synthesis
        Type: general
      – SubjectFull: Molecular structure
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      – SubjectFull: Amides
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      – SubjectFull: Cell-mediated cytotoxicity
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      – SubjectFull: Solid state chemistry
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      – SubjectFull: Organotitanium compounds
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      – SubjectFull: X-ray diffraction
        Type: general
      – SubjectFull: Cancer cells
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      – TitleFull: Synthesis, structure and biological activity of amide-functionalized titanocenyls: Improving their cytotoxic properties
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            NameFull: Matta, Jaime
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            NameFull: Rheingold, Arnold L.
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              Text: Dec2009
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