Biological Monitoring the Exposure to Polycyclic Aromatic Hydrocarbons of Coke Oven Workers in Relation to Smoking and Genetic Polymorphisms for GSTM1 and GSTT1.
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| Title: | Biological Monitoring the Exposure to Polycyclic Aromatic Hydrocarbons of Coke Oven Workers in Relation to Smoking and Genetic Polymorphisms for GSTM1 and GSTT1. |
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| Authors: | VAN DELFT, JOOST H. M.1 j.vandelft@grat.unimaas.nl, STEENWINKEL, MARIE-JOSÉ S. T.1, VAN ASTEN, JEFF G.1, DE VOGEL, NICO1, BRUIJNTJES-ROZIER, TRUUS C. D. M.1, SCHOUTEN, TON2, CRAMERS, PATRICIA3, MAAS, LOU3, VAN HERWIJNEN, MARCEL H.3, VAN SCHOOTEN, FREDERIK-JAN3, HOPMANS, PIET M. J.4 |
| Source: | Annals of Occupational Hygiene. Jul2001, Vol. 45 Issue 5, p395-408. 14p. |
| Subjects: | Physiological effects of polycyclic aromatic hydrocarbons, Industrial toxicology, Hydrocarbons, Lung cancer, Cancer risk factors, Industrial workers, Glutathione transferase, Genes, Lymphocytes |
| Abstract: | Occupational exposure to polycyclic aromatic hydrocarbons (PAH) increases the risk of developing lung cancer. Human exposure is often demonstrated by increased internal levels of PAH metabolites and of markers for early biological effects, like DNA adducts and cytogenetic aberrations. Objective: This study aimed to assess whether the current exposure to PAH of coke oven workers in a Dutch plant induced biological effects, and to determine if these effects are influenced by tobacco smoking and by genetic polymorphisms for the glutathione S-transferase genes GSTM1 and GSTT1. Methods: Urinary 1-hydroxypyrene (1-OHpyr) levels were used to monitor the internal dose, while the internal effective dose was assessed by monitoring PAH-DNA adducts, DNA strand breaks (Comet assay), sister-chromatid exchanges (SCE) and cells with a high frequency of SCE (HFC) in lymphocytes together with micronuclei (MN) in exfoliated urothelial cells. Results: Occupational exposure to PAH resulted in statistically significant increased 1- OHpyr levels (P 0.001), but it did not cause a significant induction of SCE, HFC, MN, DNA strand breaks or DNA adducts. Smoking caused a significant increase of 1-OHpyr (P 0.05), SCE (P 0.001), HFC (P 0.001) and DNA adducts (P 0.05), but not of MN or DNA strand breaks. Following correction for the smoking-related effects, no occupational induction of the effect biomarkers could be discerned. Multi-variate analysis did not show a significant influence of GSTM1 and GSTT1 polymorphisms on any biomarker. Also no significant interactions were observed between the various biomarkers. Conclusion: This study shows that in the examined plant, the occupational exposure to PAH does not result in measurable early biological effects [ABSTRACT FROM AUTHOR] |
| Copyright of Annals of Occupational Hygiene is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 45226828 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Biological Monitoring the Exposure to Polycyclic Aromatic Hydrocarbons of Coke Oven Workers in Relation to Smoking and Genetic Polymorphisms for GSTM1 and GSTT1. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22VAN+DELFT%2C+JOOST+H%2E+M%2E%22">VAN DELFT, JOOST H. M.</searchLink><relatesTo>1</relatesTo><i> j.vandelft@grat.unimaas.nl</i><br /><searchLink fieldCode="AR" term="%22STEENWINKEL%2C+MARIE-JOSÉ+S%2E+T%2E%22">STEENWINKEL, MARIE-JOSÉ S. T.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22VAN+ASTEN%2C+JEFF+G%2E%22">VAN ASTEN, JEFF G.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22DE+VOGEL%2C+NICO%22">DE VOGEL, NICO</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22BRUIJNTJES-ROZIER%2C+TRUUS+C%2E+D%2E+M%2E%22">BRUIJNTJES-ROZIER, TRUUS C. D. M.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22SCHOUTEN%2C+TON%22">SCHOUTEN, TON</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22CRAMERS%2C+PATRICIA%22">CRAMERS, PATRICIA</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22MAAS%2C+LOU%22">MAAS, LOU</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22VAN+HERWIJNEN%2C+MARCEL+H%2E%22">VAN HERWIJNEN, MARCEL H.</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22VAN+SCHOOTEN%2C+FREDERIK-JAN%22">VAN SCHOOTEN, FREDERIK-JAN</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22HOPMANS%2C+PIET+M%2E+J%2E%22">HOPMANS, PIET M. J.</searchLink><relatesTo>4</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Annals+of+Occupational+Hygiene%22">Annals of Occupational Hygiene</searchLink>. Jul2001, Vol. 45 Issue 5, p395-408. 14p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Physiological+effects+of+polycyclic+aromatic+hydrocarbons%22">Physiological effects of polycyclic aromatic hydrocarbons</searchLink><br /><searchLink fieldCode="DE" term="%22Industrial+toxicology%22">Industrial toxicology</searchLink><br /><searchLink fieldCode="DE" term="%22Hydrocarbons%22">Hydrocarbons</searchLink><br /><searchLink fieldCode="DE" term="%22Lung+cancer%22">Lung cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+risk+factors%22">Cancer risk factors</searchLink><br /><searchLink fieldCode="DE" term="%22Industrial+workers%22">Industrial workers</searchLink><br /><searchLink fieldCode="DE" term="%22Glutathione+transferase%22">Glutathione transferase</searchLink><br /><searchLink fieldCode="DE" term="%22Genes%22">Genes</searchLink><br /><searchLink fieldCode="DE" term="%22Lymphocytes%22">Lymphocytes</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Occupational exposure to polycyclic aromatic hydrocarbons (PAH) increases the risk of developing lung cancer. Human exposure is often demonstrated by increased internal levels of PAH metabolites and of markers for early biological effects, like DNA adducts and cytogenetic aberrations. Objective: This study aimed to assess whether the current exposure to PAH of coke oven workers in a Dutch plant induced biological effects, and to determine if these effects are influenced by tobacco smoking and by genetic polymorphisms for the glutathione S-transferase genes GSTM1 and GSTT1. Methods: Urinary 1-hydroxypyrene (1-OHpyr) levels were used to monitor the internal dose, while the internal effective dose was assessed by monitoring PAH-DNA adducts, DNA strand breaks (Comet assay), sister-chromatid exchanges (SCE) and cells with a high frequency of SCE (HFC) in lymphocytes together with micronuclei (MN) in exfoliated urothelial cells. Results: Occupational exposure to PAH resulted in statistically significant increased 1- OHpyr levels (P 0.001), but it did not cause a significant induction of SCE, HFC, MN, DNA strand breaks or DNA adducts. Smoking caused a significant increase of 1-OHpyr (P 0.05), SCE (P 0.001), HFC (P 0.001) and DNA adducts (P 0.05), but not of MN or DNA strand breaks. Following correction for the smoking-related effects, no occupational induction of the effect biomarkers could be discerned. Multi-variate analysis did not show a significant influence of GSTM1 and GSTT1 polymorphisms on any biomarker. Also no significant interactions were observed between the various biomarkers. Conclusion: This study shows that in the examined plant, the occupational exposure to PAH does not result in measurable early biological effects [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Annals of Occupational Hygiene is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1093/annhyg/45.5.395 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 14 StartPage: 395 Subjects: – SubjectFull: Physiological effects of polycyclic aromatic hydrocarbons Type: general – SubjectFull: Industrial toxicology Type: general – SubjectFull: Hydrocarbons Type: general – SubjectFull: Lung cancer Type: general – SubjectFull: Cancer risk factors Type: general – SubjectFull: Industrial workers Type: general – SubjectFull: Glutathione transferase Type: general – SubjectFull: Genes Type: general – SubjectFull: Lymphocytes Type: general Titles: – TitleFull: Biological Monitoring the Exposure to Polycyclic Aromatic Hydrocarbons of Coke Oven Workers in Relation to Smoking and Genetic Polymorphisms for GSTM1 and GSTT1. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: VAN DELFT, JOOST H. M. – PersonEntity: Name: NameFull: STEENWINKEL, MARIE-JOSÉ S. T. – PersonEntity: Name: NameFull: VAN ASTEN, JEFF G. – PersonEntity: Name: NameFull: DE VOGEL, NICO – PersonEntity: Name: NameFull: BRUIJNTJES-ROZIER, TRUUS C. D. M. – PersonEntity: Name: NameFull: SCHOUTEN, TON – PersonEntity: Name: NameFull: CRAMERS, PATRICIA – PersonEntity: Name: NameFull: MAAS, LOU – PersonEntity: Name: NameFull: VAN HERWIJNEN, MARCEL H. – PersonEntity: Name: NameFull: VAN SCHOOTEN, FREDERIK-JAN – PersonEntity: Name: NameFull: HOPMANS, PIET M. J. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: Jul2001 Type: published Y: 2001 Identifiers: – Type: issn-print Value: 00034878 Numbering: – Type: volume Value: 45 – Type: issue Value: 5 Titles: – TitleFull: Annals of Occupational Hygiene Type: main |
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