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Hydrotropic oligomer-conjugated glycol chitosan as a carrier of paclitaxel: Synthesis, characterization, and in vivo biodistribution

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Title: Hydrotropic oligomer-conjugated glycol chitosan as a carrier of paclitaxel: Synthesis, characterization, and in vivo biodistribution
Authors: Saravanakumar, G.1, Min, Kyung Hyun2,3, Min, Dong Sik2,3, Kim, Ah Young2,3, Lee, Chang-Moon4, Cho, Yong Woo4, Lee, Sang Cheon5, Kim, Kwangmeyung3, Jeong, Seo Young2, Park, Kinam6, Park, Jae Hyung1,2, Kwon, Ick Chan3 ikwon@kist.re.kr
Source: Journal of Controlled Release. Dec2009, Vol. 140 Issue 3, p210-217. 8p.
Subjects: Oligomers, Chitosan, Paclitaxel, Water-soluble polymers, Cancer treatment, Nanoparticles, Drug carriers
Abstract: Abstract: Development of successful formulations for poorly water-soluble drugs remains a longstanding critical and challenging issue in cancer therapy. As a potential drug carrier of paclitaxel, hydrotropic oligomer-glycol chitosan (HO-GC) was synthesized by chemical conjugation of the N,N-diethylnicotinamide-based oligomer, uniquely designed for enhancing the aqueous solubility of paclitaxel, to the backbone of glycol chitosan. Owing to its amphiphilicity, the conjugate formed self-assembled nanoparticles with a mean diameter of 313±13nm in a phosphate-buffered saline (PBS, pH 7.4 at 37°C). HO-GC nanoparticles maintained their structure for up to 50days in PBS. They could encapsulate a high quantity (20wt.%) of paclitaxel (PTX) with a maximum drug-loading efficiency of 97%, due to the presence of hydrotropic inner cores. When HO-GC-PTX particles were exposed to the 0.1M sodium salicylate solution in PBS (pH 7.4), PTX was released from nanoparticles in a sustained manner. From the cytotoxicity test, it was confirmed that HO-GC-PTX nanoparticles showed lower cytotoxicity than free PTX formulation in 50%/50% Cremophor EL/ethanol mixture. The optical imaging results indicated that near-infrared fluorescence dye (Cy5.5)-labeled HO-GC-PTX showed an excellent tumor specificity in SCC7 tumor-bearing mice, due to the enhanced permeation and retention effect. Overall, HO-GC-PTX nanoparticles might be a promising carrier for PTX delivery in cancer therapy. [Copyright &y& Elsevier]
Copyright of Journal of Controlled Release is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 45552941
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Hydrotropic oligomer-conjugated glycol chitosan as a carrier of paclitaxel: Synthesis, characterization, and in vivo biodistribution
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  Data: <searchLink fieldCode="AR" term="%22Saravanakumar%2C+G%2E%22">Saravanakumar, G.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Min%2C+Kyung+Hyun%22">Min, Kyung Hyun</searchLink><relatesTo>2,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Min%2C+Dong+Sik%22">Min, Dong Sik</searchLink><relatesTo>2,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Kim%2C+Ah+Young%22">Kim, Ah Young</searchLink><relatesTo>2,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Lee%2C+Chang-Moon%22">Lee, Chang-Moon</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Cho%2C+Yong+Woo%22">Cho, Yong Woo</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Lee%2C+Sang+Cheon%22">Lee, Sang Cheon</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Kim%2C+Kwangmeyung%22">Kim, Kwangmeyung</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Jeong%2C+Seo+Young%22">Jeong, Seo Young</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Park%2C+Kinam%22">Park, Kinam</searchLink><relatesTo>6</relatesTo><br /><searchLink fieldCode="AR" term="%22Park%2C+Jae+Hyung%22">Park, Jae Hyung</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Kwon%2C+Ick+Chan%22">Kwon, Ick Chan</searchLink><relatesTo>3</relatesTo><i> ikwon@kist.re.kr</i>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Controlled+Release%22">Journal of Controlled Release</searchLink>. Dec2009, Vol. 140 Issue 3, p210-217. 8p.
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  Data: <searchLink fieldCode="DE" term="%22Oligomers%22">Oligomers</searchLink><br /><searchLink fieldCode="DE" term="%22Chitosan%22">Chitosan</searchLink><br /><searchLink fieldCode="DE" term="%22Paclitaxel%22">Paclitaxel</searchLink><br /><searchLink fieldCode="DE" term="%22Water-soluble+polymers%22">Water-soluble polymers</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+treatment%22">Cancer treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Nanoparticles%22">Nanoparticles</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+carriers%22">Drug carriers</searchLink>
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  Data: Abstract: Development of successful formulations for poorly water-soluble drugs remains a longstanding critical and challenging issue in cancer therapy. As a potential drug carrier of paclitaxel, hydrotropic oligomer-glycol chitosan (HO-GC) was synthesized by chemical conjugation of the N,N-diethylnicotinamide-based oligomer, uniquely designed for enhancing the aqueous solubility of paclitaxel, to the backbone of glycol chitosan. Owing to its amphiphilicity, the conjugate formed self-assembled nanoparticles with a mean diameter of 313±13nm in a phosphate-buffered saline (PBS, pH 7.4 at 37°C). HO-GC nanoparticles maintained their structure for up to 50days in PBS. They could encapsulate a high quantity (20wt.%) of paclitaxel (PTX) with a maximum drug-loading efficiency of 97%, due to the presence of hydrotropic inner cores. When HO-GC-PTX particles were exposed to the 0.1M sodium salicylate solution in PBS (pH 7.4), PTX was released from nanoparticles in a sustained manner. From the cytotoxicity test, it was confirmed that HO-GC-PTX nanoparticles showed lower cytotoxicity than free PTX formulation in 50%/50% Cremophor EL/ethanol mixture. The optical imaging results indicated that near-infrared fluorescence dye (Cy5.5)-labeled HO-GC-PTX showed an excellent tumor specificity in SCC7 tumor-bearing mice, due to the enhanced permeation and retention effect. Overall, HO-GC-PTX nanoparticles might be a promising carrier for PTX delivery in cancer therapy. [Copyright &y& Elsevier]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Controlled Release is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=45552941
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      – Type: doi
        Value: 10.1016/j.jconrel.2009.06.015
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      – Code: eng
        Text: English
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        PageCount: 8
        StartPage: 210
    Subjects:
      – SubjectFull: Oligomers
        Type: general
      – SubjectFull: Chitosan
        Type: general
      – SubjectFull: Paclitaxel
        Type: general
      – SubjectFull: Water-soluble polymers
        Type: general
      – SubjectFull: Cancer treatment
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      – SubjectFull: Nanoparticles
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      – SubjectFull: Drug carriers
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              Text: Dec2009
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