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Prediction of potential antimalarial targets of artemisinin based on protein information from whole genome of Plasmodium falciparum.

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Title: Prediction of potential antimalarial targets of artemisinin based on protein information from whole genome of Plasmodium falciparum.
Authors: Han Li Ping1, Huang Qiang1, Nan Peng1, Zhong Yang1,2 yangzhong@fudan.edu.cn
Source: Chinese Science Bulletin. Nov2009, Vol. 54 Issue 22, p4234-4240. 7p. 2 Charts, 5 Graphs.
Subjects: Plasmodium falciparum, Artemisinin, Antimalarials, Proteins, Databases, Methionine
Abstract: On the basis of the genomic data and protein pathway information about Plasmodium falciparum clone 3D7 from the NCBI taxonomy database and the KEGG database, eight key protein enzymes in the signal pathways were selected to perform molecular docking with artemisinin. The binding modes obtained from the molecular docking suggested that purine nucleoside phosphorylase (pfPNP), peptide deformylase (pfPDF), and ribose 5-phosphate isomerase (pfRpiA) may be involved in the antimalarial mode of action of artemisinin. Artemisinin exhibited its antimalarial activity probably by interfering with the metabolic pathways of purine, pyrimidine, methionine, glyoxylate and dicarboxylate, or pentose phosphate. [ABSTRACT FROM AUTHOR]
Copyright of Chinese Science Bulletin is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
An: 47027421
AccessLevel: 6
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PubTypeId: academicJournal
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  Label: Title
  Group: Ti
  Data: Prediction of potential antimalarial targets of artemisinin based on protein information from whole genome of Plasmodium falciparum.
– Name: Author
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  Data: <searchLink fieldCode="AR" term="%22Han+Li+Ping%22">Han Li Ping</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Huang+Qiang%22">Huang Qiang</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Nan+Peng%22">Nan Peng</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Zhong+Yang%22">Zhong Yang</searchLink><relatesTo>1,2</relatesTo><i> yangzhong@fudan.edu.cn</i>
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  Data: <searchLink fieldCode="JN" term="%22Chinese+Science+Bulletin%22">Chinese Science Bulletin</searchLink>. Nov2009, Vol. 54 Issue 22, p4234-4240. 7p. 2 Charts, 5 Graphs.
– Name: Subject
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  Data: <searchLink fieldCode="DE" term="%22Plasmodium+falciparum%22">Plasmodium falciparum</searchLink><br /><searchLink fieldCode="DE" term="%22Artemisinin%22">Artemisinin</searchLink><br /><searchLink fieldCode="DE" term="%22Antimalarials%22">Antimalarials</searchLink><br /><searchLink fieldCode="DE" term="%22Proteins%22">Proteins</searchLink><br /><searchLink fieldCode="DE" term="%22Databases%22">Databases</searchLink><br /><searchLink fieldCode="DE" term="%22Methionine%22">Methionine</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: On the basis of the genomic data and protein pathway information about Plasmodium falciparum clone 3D7 from the NCBI taxonomy database and the KEGG database, eight key protein enzymes in the signal pathways were selected to perform molecular docking with artemisinin. The binding modes obtained from the molecular docking suggested that purine nucleoside phosphorylase (pfPNP), peptide deformylase (pfPDF), and ribose 5-phosphate isomerase (pfRpiA) may be involved in the antimalarial mode of action of artemisinin. Artemisinin exhibited its antimalarial activity probably by interfering with the metabolic pathways of purine, pyrimidine, methionine, glyoxylate and dicarboxylate, or pentose phosphate. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Chinese Science Bulletin is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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    Identifiers:
      – Type: doi
        Value: 10.1007/s11434-009-0634-0
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 7
        StartPage: 4234
    Subjects:
      – SubjectFull: Plasmodium falciparum
        Type: general
      – SubjectFull: Artemisinin
        Type: general
      – SubjectFull: Antimalarials
        Type: general
      – SubjectFull: Proteins
        Type: general
      – SubjectFull: Databases
        Type: general
      – SubjectFull: Methionine
        Type: general
    Titles:
      – TitleFull: Prediction of potential antimalarial targets of artemisinin based on protein information from whole genome of Plasmodium falciparum.
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            NameFull: Han Li Ping
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            NameFull: Huang Qiang
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            NameFull: Nan Peng
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            NameFull: Zhong Yang
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            – D: 15
              M: 11
              Text: Nov2009
              Type: published
              Y: 2009
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              Value: 54
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            – TitleFull: Chinese Science Bulletin
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