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New coupling strategy for radionuclide labeling of synthetic polymers

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Title: New coupling strategy for radionuclide labeling of synthetic polymers
Authors: Hruby, Martin1 mhruby@centrum.cz, Kucka, Jan1,2 jkucka@centrum.cz, Novakova, Michaela1,2 misha.novakova@seznam.cz, Mackova, Hana1 mackova@imc.cas.cz, Vetrik, Miroslav1,2 vetrix@seznam.cz
Source: Applied Radiation & Isotopes. Feb2010, Vol. 68 Issue 2, p334-339. 6p.
Subjects: Radioisotopes, Radiolabeling, Polymers, Azo dyes, Chelation therapy, Acrylamide, Indium chelates
Abstract: Abstract: We have developed a radiolabeling strategy for synthetic polymers based on the formation of azo dye usable for both covalent and chelating labeling modalities under mild conditions. Poly[N-(2-hydroxypropyl)methacrylamide] and poly(N-isopropyl acrylamide) were used as model polymers. N-methacryloyl tyrosinamide was introduced into the polymers and the phenolic moiety was then reacted with diazotized chelator precursors. The conjugates were radiolabeled with both the covalently bound (iodine-125) and chelated (indium-111) radionuclides in high yields and sufficient in vitro stability of the labels was proven. [Copyright &y& Elsevier]
Copyright of Applied Radiation & Isotopes is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 47056581
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: New coupling strategy for radionuclide labeling of synthetic polymers
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  Data: <searchLink fieldCode="AR" term="%22Hruby%2C+Martin%22">Hruby, Martin</searchLink><relatesTo>1</relatesTo><i> mhruby@centrum.cz</i><br /><searchLink fieldCode="AR" term="%22Kucka%2C+Jan%22">Kucka, Jan</searchLink><relatesTo>1,2</relatesTo><i> jkucka@centrum.cz</i><br /><searchLink fieldCode="AR" term="%22Novakova%2C+Michaela%22">Novakova, Michaela</searchLink><relatesTo>1,2</relatesTo><i> misha.novakova@seznam.cz</i><br /><searchLink fieldCode="AR" term="%22Mackova%2C+Hana%22">Mackova, Hana</searchLink><relatesTo>1</relatesTo><i> mackova@imc.cas.cz</i><br /><searchLink fieldCode="AR" term="%22Vetrik%2C+Miroslav%22">Vetrik, Miroslav</searchLink><relatesTo>1,2</relatesTo><i> vetrix@seznam.cz</i>
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  Data: <searchLink fieldCode="DE" term="%22Radioisotopes%22">Radioisotopes</searchLink><br /><searchLink fieldCode="DE" term="%22Radiolabeling%22">Radiolabeling</searchLink><br /><searchLink fieldCode="DE" term="%22Polymers%22">Polymers</searchLink><br /><searchLink fieldCode="DE" term="%22Azo+dyes%22">Azo dyes</searchLink><br /><searchLink fieldCode="DE" term="%22Chelation+therapy%22">Chelation therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Acrylamide%22">Acrylamide</searchLink><br /><searchLink fieldCode="DE" term="%22Indium+chelates%22">Indium chelates</searchLink>
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  Data: Abstract: We have developed a radiolabeling strategy for synthetic polymers based on the formation of azo dye usable for both covalent and chelating labeling modalities under mild conditions. Poly[N-(2-hydroxypropyl)methacrylamide] and poly(N-isopropyl acrylamide) were used as model polymers. N-methacryloyl tyrosinamide was introduced into the polymers and the phenolic moiety was then reacted with diazotized chelator precursors. The conjugates were radiolabeled with both the covalently bound (iodine-125) and chelated (indium-111) radionuclides in high yields and sufficient in vitro stability of the labels was proven. [Copyright &y& Elsevier]
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  Data: <i>Copyright of Applied Radiation & Isotopes is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1016/j.apradiso.2009.11.039
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 6
        StartPage: 334
    Subjects:
      – SubjectFull: Radioisotopes
        Type: general
      – SubjectFull: Radiolabeling
        Type: general
      – SubjectFull: Polymers
        Type: general
      – SubjectFull: Azo dyes
        Type: general
      – SubjectFull: Chelation therapy
        Type: general
      – SubjectFull: Acrylamide
        Type: general
      – SubjectFull: Indium chelates
        Type: general
    Titles:
      – TitleFull: New coupling strategy for radionuclide labeling of synthetic polymers
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            NameFull: Hruby, Martin
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            NameFull: Kucka, Jan
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            NameFull: Novakova, Michaela
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            NameFull: Mackova, Hana
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            NameFull: Vetrik, Miroslav
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              Text: Feb2010
              Type: published
              Y: 2010
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              Value: 68
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