A Formal Synthesis of Porantheridine and an Epimer.
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| Title: | A Formal Synthesis of Porantheridine and an Epimer. |
|---|---|
| Authors: | Bates, Roderick W.1 roderick@ntu.edu.sg, Lu, Yongna1 |
| Source: | Journal of Organic Chemistry. 12/18/2009, Vol. 74 Issue 24, p9460-9465. 6p. |
| Subjects: | Organic synthesis, Piperidine, Silver catalysts, Ring formation (Chemistry), Stereochemistry, X-ray crystallography, Allene |
| Abstract: | A formal synthesis of porantheridine and a synthesis of its C6-epimer have been completed, employing silver-catalyzed allene cyclization to form a common cis-tsoxazolidine intermediate and related N-acyl iminium ion intermediates for side-chain introduction. The stereochemistry of this step can be controlled by choice of the N-protection method. [ABSTRACT FROM AUTHOR] |
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| Database: | Engineering Source |
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