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Collagen and mature elastic fibre organisation as a function of depth in the human cornea and limbus

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Title: Collagen and mature elastic fibre organisation as a function of depth in the human cornea and limbus
Authors: Kamma-Lorger, Christina S.1, Boote, Craig1, Hayes, Sally1, Moger, Julian2, Burghammer, Manfred3, Knupp, Carlo1, Quantock, Andrew J.1, Sorensen, Thomas4, Di Cola, Emanuela3, White, Nick5, Young, Robert D.1, Meek, Keith M.1 MeekKM@cf.ac.uk
Source: Journal of Structural Biology. Mar2010, Vol. 169 Issue 3, p424-430. 7p.
Subjects: Collagen, Cornea, X-ray diffraction, Health outcome assessment, Biomechanics, Operative surgery
Abstract: Abstract: A network of circumferentially oriented collagen fibrils exists in the periphery of the human cornea, and is thought to be pivotal in maintaining corneal biomechanical stability and curvature. However, it is unknown whether or not this key structural arrangement predominates throughout the entire corneal thickness or exists as a discrete feature at a particular tissue depth; or if it incorporates any elastic fibres and how, with respect to tissue depth, the circumcorneal annulus integrates with the orthogonally arranged collagen of the central cornea. To address these issues we performed a three-dimensional investigation of fibrous collagen and elastin architecture in the peripheral and central human cornea using synchrotron X-ray scattering and non-linear microscopy. This showed that the network of collagen fibrils circumscribing the human cornea is located in the posterior one-third of the tissue and is interlaced with significant numbers of mature elastic fibres which mirror the alignment of the collagen. The orthogonal arrangement of collagen in the central cornea is also mainly restricted to the posterior stromal layers. This information will aid the development of corneal biomechanical models aimed at explaining how normal corneal curvature is sustained and further predicting the outcome of surgical procedures. [Copyright &y& Elsevier]
Copyright of Journal of Structural Biology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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PubType: Academic Journal
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  Data: Collagen and mature elastic fibre organisation as a function of depth in the human cornea and limbus
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  Data: <searchLink fieldCode="AR" term="%22Kamma-Lorger%2C+Christina+S%2E%22">Kamma-Lorger, Christina S.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Boote%2C+Craig%22">Boote, Craig</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Hayes%2C+Sally%22">Hayes, Sally</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Moger%2C+Julian%22">Moger, Julian</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Burghammer%2C+Manfred%22">Burghammer, Manfred</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Knupp%2C+Carlo%22">Knupp, Carlo</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Quantock%2C+Andrew+J%2E%22">Quantock, Andrew J.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Sorensen%2C+Thomas%22">Sorensen, Thomas</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Di+Cola%2C+Emanuela%22">Di Cola, Emanuela</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22White%2C+Nick%22">White, Nick</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Young%2C+Robert+D%2E%22">Young, Robert D.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Meek%2C+Keith+M%2E%22">Meek, Keith M.</searchLink><relatesTo>1</relatesTo><i> MeekKM@cf.ac.uk</i>
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  Data: <searchLink fieldCode="DE" term="%22Collagen%22">Collagen</searchLink><br /><searchLink fieldCode="DE" term="%22Cornea%22">Cornea</searchLink><br /><searchLink fieldCode="DE" term="%22X-ray+diffraction%22">X-ray diffraction</searchLink><br /><searchLink fieldCode="DE" term="%22Health+outcome+assessment%22">Health outcome assessment</searchLink><br /><searchLink fieldCode="DE" term="%22Biomechanics%22">Biomechanics</searchLink><br /><searchLink fieldCode="DE" term="%22Operative+surgery%22">Operative surgery</searchLink>
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  Data: Abstract: A network of circumferentially oriented collagen fibrils exists in the periphery of the human cornea, and is thought to be pivotal in maintaining corneal biomechanical stability and curvature. However, it is unknown whether or not this key structural arrangement predominates throughout the entire corneal thickness or exists as a discrete feature at a particular tissue depth; or if it incorporates any elastic fibres and how, with respect to tissue depth, the circumcorneal annulus integrates with the orthogonally arranged collagen of the central cornea. To address these issues we performed a three-dimensional investigation of fibrous collagen and elastin architecture in the peripheral and central human cornea using synchrotron X-ray scattering and non-linear microscopy. This showed that the network of collagen fibrils circumscribing the human cornea is located in the posterior one-third of the tissue and is interlaced with significant numbers of mature elastic fibres which mirror the alignment of the collagen. The orthogonal arrangement of collagen in the central cornea is also mainly restricted to the posterior stromal layers. This information will aid the development of corneal biomechanical models aimed at explaining how normal corneal curvature is sustained and further predicting the outcome of surgical procedures. [Copyright &y& Elsevier]
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  Data: <i>Copyright of Journal of Structural Biology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1016/j.jsb.2009.11.004
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        Text: English
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        PageCount: 7
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      – SubjectFull: Collagen
        Type: general
      – SubjectFull: Cornea
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      – SubjectFull: X-ray diffraction
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              Text: Mar2010
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